Progress in the Application of Network Pharmacology in Mongolian Medicine Research

This paper summarizes the status quo of Mongolian medicine research,the basic research ideas and contents of network pharmacology,the latest development of network pharmacology technology in the field of Mongolian medicine research,the application progress,future development direction and existing problems in the research of Mongolian medicine,so as to provide new ideas and new methods for the scientific research of traditional medicine.

Research Progress of Cymbaria mongolica Maxim.in the Treatment of Chronic Eczema

Chronic eczema is a kind of skin disease which is difficult to treat.It is easy to occur repeatedly,and itching is intolerable during the attack,which seriously affects the daily life of patients.Through the review of the treatment of chronic eczema with Mongolian medicine Cymbaria mongolica Maxim.,it has the advantages of improving the cure rate and the quality of life,and reducing the recurrence rate,and so on,which provides a scientific basis for the promotion and further research of traditional Mongolian medicine Cymbaria mongolica Maxim.

妊娠早期七氟醚全麻对仔鼠海马、顶叶皮质中干扰素诱导蛋白表达及炎性反应的影响

目的 探讨妊娠早期七氟醚全麻对仔鼠海马、顶叶皮质中干扰素诱导蛋白(AIM2)表达及炎性反应的影响。方法 将24只胎龄为5~7 d的Sprague-Dawley(SD)大鼠按照随机数字表法随机分为对照组、七氟醚全麻1组(S1组)和七氟醚全麻2组(S2组),每组8只。大鼠分娩后每组随机抽取8只仔鼠,维持生存30 d后,通过Morris水迷宫实验评估仔鼠学习记忆能力。收集出生后30 d的仔鼠脑标本,通过苏木精/伊红染色、尼氏染色观察海马和顶叶皮质神经元结构的形态变化和尼氏体。通过免疫组化法和蛋白质印迹法检测仔鼠海马和顶叶皮质中AIM2、CD45、白细胞介素1β(IL-1β)、pro-caspase-1和caspase-1 p10表达。结果 与对照组相比,S1组和S2组仔鼠长期学习和记忆能力较差,对海马和顶叶皮质的损伤程度不同。与对照组相比,S1组和S2组仔鼠中的AIM2、CD45、IL-1β、pro-caspase-1和caspase-1 p10表达升高(P均<0.05),且S2组高于S1组(P均<0.05)。结论 妊娠早期七氟醚全麻可促进仔鼠海马和顶叶皮质中AIM2表达及炎性反应的发生。