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CXXC5 is required for cardiac looping via TGF-βsignaling pathway in zebrafish
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作者 Ping zhu Xiyang Peng +21 位作者 Guanming Li Yuequn Wang Jian Zhuang Jimei Chen Rong Luo Fa Chen Yan Shi Jiani Li Xiaoyang Mo Xianchu Liu wuzhou yuan Qun Zeng Yongqing Li Zhigang Jiang Yongqi Wan Zuoqiong Zhou Xiangli Ye Wei Xu Xijun Wang Xiongwei Fan Xiushan Wu Yun Deng 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Mapping the transcription repressive domain in the highly conserved human gene hnulp1
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作者 Yuequn WANG Lian LIU +6 位作者 Zhenyu CAI Yongqing LI wuzhou yuan Chuanbing ZHU Yun DENG Xiaoyang MO Xiushan WU 《Frontiers in Biology》 CSCD 2008年第2期137-142,共6页
HNULP1,a new member of the basic helixloop-helix transcription factors,contains a DUF654 domain in its C-terminus and is highly conserved from Drosophilae,yeast,zebrafish to mouse.The function of this motif,however,is... HNULP1,a new member of the basic helixloop-helix transcription factors,contains a DUF654 domain in its C-terminus and is highly conserved from Drosophilae,yeast,zebrafish to mouse.The function of this motif,however,is currently unknown.In this research,we fused five deletion fragments of the DUF654 domain to the GAL4 DNA-binding domain and then co-transfected with plasmids L8G5-Luc and VP-16.The analysis of the GAL4 luciferase reporter gene indicated that fragments from 228 to 407 amino acids in the DUF654 domain had a strong transcription repression activity.Therefore,this study lays a solid foundation for research on the mechanism of hnulp1 transcriptional regulation and the function of the DUF654 domain. 展开更多
关键词 DUF654 luciferase reporter gene transcriptional activity hnulp1
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