Polo-like kinase 1(Plk1)is a key regulator of cell division in eukaryotic cells.In this short review,we briefly summarized the well-established functions modulated by Plk1 during mitosis.Beyond mitosis,we focused main...Polo-like kinase 1(Plk1)is a key regulator of cell division in eukaryotic cells.In this short review,we briefly summarized the well-established functions modulated by Plk1 during mitosis.Beyond mitosis,we focused mainly on the unexpected processes in which Plk1 emerges as a critical player,including microtubule dynamics,DNA replication,chromosome dynamics,p53 regulation,and recovery from the G2 DNA-damage checkpoint.Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.展开更多
文摘Polo-like kinase 1(Plk1)is a key regulator of cell division in eukaryotic cells.In this short review,we briefly summarized the well-established functions modulated by Plk1 during mitosis.Beyond mitosis,we focused mainly on the unexpected processes in which Plk1 emerges as a critical player,including microtubule dynamics,DNA replication,chromosome dynamics,p53 regulation,and recovery from the G2 DNA-damage checkpoint.Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.
