通过研究炎症小体激活与干燥综合征(Sjögren’ssyndrome,SS)小鼠组织病理学改变和唾液流量等变化的关系,阐述炎症小体参与SS的作用机制。选用非肥胖型糖尿病(non-obesediabetic,NOD)小鼠作为SS模型,美国癌症研究所(Institute of Ca...通过研究炎症小体激活与干燥综合征(Sjögren’ssyndrome,SS)小鼠组织病理学改变和唾液流量等变化的关系,阐述炎症小体参与SS的作用机制。选用非肥胖型糖尿病(non-obesediabetic,NOD)小鼠作为SS模型,美国癌症研究所(Institute of Cancer Rsearche,ICR)小鼠作为对照;检测和比较SS和对照小鼠唾液流量、颌下腺和肺脏组织病理学表现及炎症小体表达水平;分别注射LPS激活或者注射BAY_11-7082抑制NOD小鼠炎症小体通路,检测处理后小鼠唾液流量、颌下腺和肺脏组织病理学表现以及炎症小体通路分子表达变化。结果显示,与ICR小鼠相比,NOD小鼠唾液流量减少(P<0.05),颌下腺有淋巴细胞浸润,肺部存在慢性病变,炎症小体通路活化;LPS注射进一步激活SS小鼠体内炎症小体后,唾液流量降低(P<0.001),颌下腺和肺部炎性淋巴细胞浸润增多,血清中IL-1β和IL-18表达增加(均P<0.05);BAY_11-7082抑制SS小鼠体内炎症小体通路后,唾液流量增加(P<0.05),颌下腺和肺部炎性淋巴细胞浸润减少,血清IL-1β和IL-18表达显著降低(均P<0.05)。由此,SS小鼠炎症小体通路活化,激活炎症小体会加重小鼠的SS样症状,抑制炎症小体活化则减轻小鼠SS样症状。以上结果提示,炎症小体活化参与SS发病,靶向抑制是SS治疗的潜在方向。展开更多
As a key part of the manufacturing industry,the rubber and plastic industry is widely used in a variety of fields such as automotive manufacturing,construction materials,and electronics.With technological innovation,g...As a key part of the manufacturing industry,the rubber and plastic industry is widely used in a variety of fields such as automotive manufacturing,construction materials,and electronics.With technological innovation,global economic growth and infrastructure construction driving the demand for rubber and plastic materials,rubber and plastic materials play an important role in various fields,and accurate translation of the industry’s terminology is also crucial for international communication.The purpose of this paper is to explore in depth the lexical features of rubber and plastic industry terminology,including strong specialization,specialization of common vocabulary,and diversity of word formation.In view of these lexical features,relevant Chinese translation strategies are discussed to ensure the accuracy,specialization and comprehensibility of the translation of rubber and plastic industry terms.展开更多
文摘通过研究炎症小体激活与干燥综合征(Sjögren’ssyndrome,SS)小鼠组织病理学改变和唾液流量等变化的关系,阐述炎症小体参与SS的作用机制。选用非肥胖型糖尿病(non-obesediabetic,NOD)小鼠作为SS模型,美国癌症研究所(Institute of Cancer Rsearche,ICR)小鼠作为对照;检测和比较SS和对照小鼠唾液流量、颌下腺和肺脏组织病理学表现及炎症小体表达水平;分别注射LPS激活或者注射BAY_11-7082抑制NOD小鼠炎症小体通路,检测处理后小鼠唾液流量、颌下腺和肺脏组织病理学表现以及炎症小体通路分子表达变化。结果显示,与ICR小鼠相比,NOD小鼠唾液流量减少(P<0.05),颌下腺有淋巴细胞浸润,肺部存在慢性病变,炎症小体通路活化;LPS注射进一步激活SS小鼠体内炎症小体后,唾液流量降低(P<0.001),颌下腺和肺部炎性淋巴细胞浸润增多,血清中IL-1β和IL-18表达增加(均P<0.05);BAY_11-7082抑制SS小鼠体内炎症小体通路后,唾液流量增加(P<0.05),颌下腺和肺部炎性淋巴细胞浸润减少,血清IL-1β和IL-18表达显著降低(均P<0.05)。由此,SS小鼠炎症小体通路活化,激活炎症小体会加重小鼠的SS样症状,抑制炎症小体活化则减轻小鼠SS样症状。以上结果提示,炎症小体活化参与SS发病,靶向抑制是SS治疗的潜在方向。
文摘As a key part of the manufacturing industry,the rubber and plastic industry is widely used in a variety of fields such as automotive manufacturing,construction materials,and electronics.With technological innovation,global economic growth and infrastructure construction driving the demand for rubber and plastic materials,rubber and plastic materials play an important role in various fields,and accurate translation of the industry’s terminology is also crucial for international communication.The purpose of this paper is to explore in depth the lexical features of rubber and plastic industry terminology,including strong specialization,specialization of common vocabulary,and diversity of word formation.In view of these lexical features,relevant Chinese translation strategies are discussed to ensure the accuracy,specialization and comprehensibility of the translation of rubber and plastic industry terms.
