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普瑞巴林缓释片体外释放度及比格犬体内药代动力学研究 被引量:1
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作者 夏韵婕 王增明 +3 位作者 高静 张慧 郑爱萍 陈文 《国际药学研究杂志》 CAS 北大核心 2020年第8期658-665,共8页
目的对自制普瑞巴林缓释片和原研制剂Lyrica®CR的体外释放度、释放机制以及剂量倾泻进行评价。进一步以Beagle犬为模型考察自制制剂与原研制剂的体内药代动力学情况。方法以美国辉瑞公司的普瑞巴林缓释片(Lyrica®CR)为原研制... 目的对自制普瑞巴林缓释片和原研制剂Lyrica®CR的体外释放度、释放机制以及剂量倾泻进行评价。进一步以Beagle犬为模型考察自制制剂与原研制剂的体内药代动力学情况。方法以美国辉瑞公司的普瑞巴林缓释片(Lyrica®CR)为原研制剂,使用自动溶出仪进行体外释放行为评价,采用相似因子(f2)法进行原研制剂与自制制剂体外释放相似度分析,并拟合体外释放方程评价其释药机制。综合美国、欧洲、中国的相关指导原则对制剂进行剂量倾泻研究。最后比较了自制制剂与原研制剂在Beagle犬的体内药代动力学参数。结果自制制剂与原研制剂在五种释放介质中f2均>80,在含乙醇的释放介质中无突释现象。自制制剂与原研制剂的药动学参数Tmax分别为(6.00±2.19)和(4.00±2.19)h,Cmax分别为(19.35±11.43)和(17.25±7.77)μg/ml,AUC0-t分别为(340.37±220.66)和(281.65±196.25)h·μg/ml。结论本研究自制制剂与原研制剂在五种介质中释放曲线相似,药物呈缓慢释放无剂量倾泻现象,体外释放机制相似。自制制剂与原研制剂在比格犬体内各药代动力学参数差异均无统计学意义,相对生物利用度达80%以上。 展开更多
关键词 普瑞巴林 缓释片 体外释放度 药代动力学
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Entanglement Dynamics and Bell Violations of Two Atoms in Tavis-Cummings Model with Phase Decoherence 被引量:2
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作者 SHAN Chuan-Jia CHENG Wei-Wen +2 位作者 LIU Tang-Kun GUO De-Jun xia yun-jie 《Communications in Theoretical Physics》 SCIE CAS CSCD 2008年第6期1505-1514,共10页
Considering the dipole-dipole coupling intensity between two atoms and the field in the Fock state, the entanglement dynamics between two atoms that are initially entangled in the system of two two-level atoms coupled... Considering the dipole-dipole coupling intensity between two atoms and the field in the Fock state, the entanglement dynamics between two atoms that are initially entangled in the system of two two-level atoms coupled to a single mode cavity in the presence of phase decoherence has been investigated. The two-atom entanglement appears with periodicity without considering phase decoherence, however, the phase decoherence causes the decay of entanglement between two atoms, with the increasing of the phase decoherence coefficient, the entanglement will quickly become a constant value, which is affected by the two-atom initial state. Meanwhile the two-atom quantum state will forever stay in the maximal entangled state when the initial state is proper even in the presence of phase decoherence. On the other hand, the Bell violation and the entanglement do not satisfy the monotonous relation, a large Bell violation implies the presence of a large amount of entanglement under certain conditions, while a large Bell violation corresponds to a little amount of entanglement in certain situations. However, the violation of Bell-CHSH inequality can reach the maximal value if two atoms are in the maximal entangled state, or vice versa. 展开更多
关键词 entanglement dynamics stable entanglement phase decoherence
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Wehrl’s Entropy and Noise 被引量:2
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作者 WU He-jun xia yun-jie 《Chinese Physics Letters》 SCIE CAS CSCD 1997年第11期808-811,共4页
The relations between Wehrl’s entropy and squeezing or total noise in the field with Gaussian Q function are established,The results show that,the Wehrl’s entropy will be reduced when the squeezing is increased or t... The relations between Wehrl’s entropy and squeezing or total noise in the field with Gaussian Q function are established,The results show that,the Wehrl’s entropy will be reduced when the squeezing is increased or the total noise is decreased.The other nonclassical properties in this kind of field are also discussed. 展开更多
关键词 ENTROPY ENTROPY SQUEEZING
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石油化工安装工程施工的质量控制及造价管理 被引量:7
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作者 夏云杰 《化工设计通讯》 CAS 2019年第5期143-143,154,共2页
现阶段社会对石油化工的需求越来越高,在一定程度上促进了石油化工工程技术的发展。但是现阶段的石油化工工程还存在一定的质量问题,其中安装工程的质量问题尤为突出。主要对石油化工安装工程施工的质量问题进行分析,接探讨如何控制石... 现阶段社会对石油化工的需求越来越高,在一定程度上促进了石油化工工程技术的发展。但是现阶段的石油化工工程还存在一定的质量问题,其中安装工程的质量问题尤为突出。主要对石油化工安装工程施工的质量问题进行分析,接探讨如何控制石油化工安装工程施工的质量,最后对石油化工安装工程的造价管理进行了分析。 展开更多
关键词 石油化工 安装工程 质量控制 造价管理
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Tunable Magneto-Optical Kerr Effect in Fe Films Underneath a Two-Dimensional Array of Polystyrene Spheres Covered by Au Nanocaps 被引量:1
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作者 ZHANG xia SHI Lei +3 位作者 LI Jing xia yun-jie SHI Zhong ZHOU Shi-Ming 《Chinese Physics Letters》 SCIE CAS CSCD 2013年第3期168-171,共4页
For Fe layers covered by two-dimensional arrays of hexagonal close-packed polystyrene spheres which are hemispherically covered by Au films on the top,fine structures are observed in reflection,magneto-optical Kerr ro... For Fe layers covered by two-dimensional arrays of hexagonal close-packed polystyrene spheres which are hemispherically covered by Au films on the top,fine structures are observed in reflection,magneto-optical Kerr rotation and ellipticity spectra.The Kerr rotation achieves peaks or exhibits a narrow resonance-like spectral lineshape near the reflection minima,depending on the mechanism of the reflection dips.The Kerr rotation peaks and the resonance-like lineshape both are shifted with the sphere diameters.These phenomena can be attributed to the excitation of surface plasmon resonance and Fabry–Pérot modes. 展开更多
关键词 spectra. ROTATION RESONANCE
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Efficient generation of Bell-cat states in remote cavities
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作者 LI Xing ZHANG Ying-Jie xia yun-jie 《Optoelectronics Letters》 EI 2008年第6期467-470,共4页
In the context of cavity quantum electrodynamics (QED),a potential scheme is proposed to generate entangled coherent states. The scheme includes twice interactions of two-level atoms with cavities. In the first intera... In the context of cavity quantum electrodynamics (QED),a potential scheme is proposed to generate entangled coherent states. The scheme includes twice interactions of two-level atoms with cavities. In the first interaction,two atoms are sent into a microwave cavity with the large detuning respectively. And then the second interaction is that the two atoms enter another microwave cavity and are driven by a resonant classical field meantime. When we choose the proper interaction time and make measurement on the two atoms,the two microwave cavity mode fields are determinatively entangled. In addition,it is easy to generalize the scheme to multi-cavity and multi-atom. 展开更多
关键词 QED 远程空泡 原子结构 量子学
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