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独立垂直钢丝技术联合钢丝环扎强化技术治疗髌骨下极骨折 被引量:1
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作者 夏招 《临床骨科杂志》 2024年第1期46-46,共1页
2018年7月~2021年6月,我科采用独立垂直钢丝技术联合钢丝环扎强化技术治疗10例髌骨下极骨折患者,疗效满意,报道如下。1材料与方法1.1病例资料本组10例,男4例,女6例,年龄45~78岁。均为摔伤,左侧7例,右侧3例。术前膝关节CT检查均显示髌骨... 2018年7月~2021年6月,我科采用独立垂直钢丝技术联合钢丝环扎强化技术治疗10例髌骨下极骨折患者,疗效满意,报道如下。1材料与方法1.1病例资料本组10例,男4例,女6例,年龄45~78岁。均为摔伤,左侧7例,右侧3例。术前膝关节CT检查均显示髌骨下极骨折,其中横行3例、粉碎性7例。伤后至手术时间1~7 d。1.2治疗方法腰硬联合麻醉下手术。患者仰卧位。在膝关节正中靠近髌骨下极做长约6 cm的纵行切口. 展开更多
关键词 独立垂直钢丝技术 髌骨下极骨折
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义气之争抑或学理之辩?——从绪方正规和北里柴三郎之争看日本医学近代化
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作者 夏钊 田妍 《广西民族大学学报(自然科学版)》 CAS 2024年第2期40-46,共7页
19-20世纪,德国医学对日本现代医学的发展作出了不可磨灭的贡献,但是日本在学习德国医学的过程中也出现了紧张与分立的状态。绪方正规和北里柴三郎同样是留学德国,但他们却因阶级、观念和师承的不同分立成两派,在学理之辩中掺杂义气之... 19-20世纪,德国医学对日本现代医学的发展作出了不可磨灭的贡献,但是日本在学习德国医学的过程中也出现了紧张与分立的状态。绪方正规和北里柴三郎同样是留学德国,但他们却因阶级、观念和师承的不同分立成两派,在学理之辩中掺杂义气之争。究其根本,这种冲突的背后是医学传统与医学近代化的冲突,即日本精英阶层与平民阶层的冲突、“吾爱吾师”和“吾更爱真理”的冲突、派系斗争和学术争论的冲突。在考察这些冲突时,不能仅强调封建等级观念在日本医学中的残余,更重要的是要看到“科学求真”逐渐成为事实评判标准的转变。日本医学近代化本质上就是从义气之争走向学理之辩的过程。 展开更多
关键词 日本医学近代化 绪方正规 北里柴三郎 义气之争 学理之辩
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合金元素对液相锌流动性的影响
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作者 夏昭 孔纲 +5 位作者 朱林龙 张哲成 万聪 车淳山 赖德林 万先兰 《材料保护》 CAS CSCD 2023年第5期164-172,共9页
液相锌的流动性不仅直接影响合金的铸造性能,而且还对热浸锌镀层厚度控制有着十分重要的意义。在液相锌中加入各种微量的合金元素可以提高流动性,从而改善热浸锌镀层的镀覆效果和表面质量,也能提高液相锌的压铸填充性能。为此,主要综述... 液相锌的流动性不仅直接影响合金的铸造性能,而且还对热浸锌镀层厚度控制有着十分重要的意义。在液相锌中加入各种微量的合金元素可以提高流动性,从而改善热浸锌镀层的镀覆效果和表面质量,也能提高液相锌的压铸填充性能。为此,主要综述了用于热浸锌的常见合金元素(Pb、Bi、Sn、Sb、Al、Mg、RE、Ni)以及部分用于压铸锌合金的合金元素(Al、Mg)对液相锌流动性的影响。 展开更多
关键词 液相锌 合金元素 流动性 热浸镀锌
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机器学习辅助预测铜铝复合材料界面结构与性能 被引量:5
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作者 夏钊 赵帆 +1 位作者 刘新华 谢建新 《中国有色金属学报》 EI CAS CSCD 北大核心 2023年第1期88-99,共12页
采用支持向量回归、人工神经网络和随机森林三种机器学习算法,建立了铜铝复合材料在连铸复合(固/液扩散)和退火(固/固扩散)时工艺参数与界面层厚度、界面结合强度的关系模型,为铜铝复合材料的界面调控提供了新方法。基于界面结合强度预... 采用支持向量回归、人工神经网络和随机森林三种机器学习算法,建立了铜铝复合材料在连铸复合(固/液扩散)和退火(固/固扩散)时工艺参数与界面层厚度、界面结合强度的关系模型,为铜铝复合材料的界面调控提供了新方法。基于界面结合强度预测模型,采用遗传算法优化连铸复合工艺,得到的优化参数为:铝液温度θ_(Al)=799℃,铜液温度θ_(Cu)=1220℃,拉坯速度v=83 mm/min,一次冷却水流量Q1=576 L/h,二次冷却水流量Q2=716 L/h。相关性计算以及界面剪切实验表明,Al_(2)Cu层对断裂过程和界面结合强度有较大影响。 展开更多
关键词 铜铝复合材料 连铸复合 界面 机器学习
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The antioxidant trolox inhibits aging and enhances prostaglandin E-2 secretion in mesenchymal stem cells
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作者 xiaOXU ZHANG LIN ZHANG +5 位作者 LIN DU HUIYAN SUN xia zhao YANG SUN WEI WANG LISHENG WANG 《BIOCELL》 SCIE 2023年第2期385-392,共8页
Mesenchymal stem cells(MSCs)have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation,differentiation,and immune regulation.However,during in vitro expansion,MSCs a... Mesenchymal stem cells(MSCs)have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation,differentiation,and immune regulation.However,during in vitro expansion,MSCs are prone to aging,which largely limits their application.Prostaglandin E-2(PGE-2)is a key effector secreted by MSCs to exert immunomodulatory effects.By screening the compound library for PGE-2 secretion,the antioxidant trolox was verified as a stimulator of MSCs to secrete PGE-2.The effect of antioxidant trolox on biological characteristics of MSCS,including aging,proliferation,and gene expression,was examined.The results demonstrated that trolox can resist aging,promote proliferation,and enhance PGE-2 secretion of MSCs without affecting their surface marker expression.Furthermore,trolox treatment up-regulates miR-17-92 clusters in MSCs and may contribute to its anti-aging effects.Thus,trolox addition might be beneficial for MSCs expansion and their application. 展开更多
关键词 Mesenchymal stem cells(MSCs) TROLOX ANTIOXIDATION Prostaglandin E-2
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胸骨悬吊剑突下途径与肋间入路胸腔镜胸腺切除术的临床对比研究
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作者 张庚鑫 尤琦 +4 位作者 孙晓东 夏钊 倪铮铮 丁伯应 朱少金 《皖南医学院学报》 CAS 2023年第1期60-62,共3页
目的:分析胸骨悬吊剑突下胸腔镜途径胸腺切除术的临床疗效。方法:回顾性分析25例行胸骨悬吊剑突下途径与74例肋间入路胸腔镜胸腺切除术患者的临床资料,分析其手术时间、术后胸管引流量、术后住院时间、疼痛评分等情况间的差异。结果:剑... 目的:分析胸骨悬吊剑突下胸腔镜途径胸腺切除术的临床疗效。方法:回顾性分析25例行胸骨悬吊剑突下途径与74例肋间入路胸腔镜胸腺切除术患者的临床资料,分析其手术时间、术后胸管引流量、术后住院时间、疼痛评分等情况间的差异。结果:剑突组与肋间组患者在年龄、性别、高血压、病灶长径、手术时间、术后引流量、疼痛评分方面差异均无统计学意义,而剑突组的淋巴结清扫个数多于肋间组,剑突组的术后住院时间短于肋间组,两者差异有统计学意义。结论:胸骨悬吊剑突下途径胸腔镜胸腺切除术治疗胸腺疾病更彻底,安全便捷,疗效满意,值得临床推广。 展开更多
关键词 胸骨悬吊 胸腔镜 剑突下 胸腺肿瘤
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微脉冲激光阈值下治疗黄斑软性玻璃膜疣和玻璃膜疣性DPED的形态学改变 被引量:4
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作者 陈青山 陈璐 +3 位作者 赵霞 陈妙虹 杨宇航 李志 《国际眼科杂志》 CAS 北大核心 2020年第6期934-939,共6页
目的:分析阈值下微脉冲激光(SMLT)治疗黄斑软性玻璃膜疣与玻璃膜疣性色素上皮脱离(DPED)的形态学改变。方法:回顾性横断面病例系列研究。2016-08/2018-10临床确诊的黄斑软性玻璃膜疣与DPED 14例20眼纳入研究,用577 nm黄激光对黄斑软性... 目的:分析阈值下微脉冲激光(SMLT)治疗黄斑软性玻璃膜疣与玻璃膜疣性色素上皮脱离(DPED)的形态学改变。方法:回顾性横断面病例系列研究。2016-08/2018-10临床确诊的黄斑软性玻璃膜疣与DPED 14例20眼纳入研究,用577 nm黄激光对黄斑软性玻璃膜疣与DPED进行SMLT治疗。观察黄斑软性玻璃膜疣与DPED治疗后BCVA,FAF与SD-OCT测量的纵径,横径,病灶面积的改变。结果:黄斑软性玻璃膜疣治疗后BCVA与基线比较,差异无统计学意义(P=0.260),DPED治疗后BCVA与基线比较无统计学差异(P=0.736)。黄斑软性玻璃膜疣与DPED横径,纵径,截面积治疗后6mo与基线比较,黄斑软性玻璃膜疣纵径高度降低,截面积缩小,与基线比较有显著性差异(P=0.008;0.034)。DPED治疗前后横径,纵径高度与截面积与基线比较无统计学差异。结论:SMLT治疗黄斑软性玻璃膜疣与DPED后BCVA没有下降。黄斑软性玻璃膜疣纵径高度与截面积均较治疗前下降。DPED与基线比较无明显改变。结果表明SMLT治疗黄斑软性玻璃膜疣是有效的,但短期DPED疗效不明显,对黄斑软性玻璃膜疣与DPED视力无损害,但仍需要前瞻性、对照、大样本及长期随访观察。 展开更多
关键词 黄斑玻璃膜疣 玻璃膜疣性色素上皮脱离 阈值下微脉冲激光 自发荧光
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特发性黄斑裂孔患者玻璃体术后黄斑结构和中央凹视网膜厚度变化 被引量:6
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作者 刘华 孙佳 +1 位作者 赵霞 白领娣 《国际眼科杂志》 CAS 北大核心 2019年第2期313-315,共3页
目的:分析特发性黄斑裂孔患者接受23G玻璃体手术治疗后黄斑结构的修复情况,以及视力和黄斑中央凹视网膜厚度的变化。方法:将2016-06/2017-12在我院进行择期手术的单眼特发性黄斑裂孔患者85例85眼纳入研究,其中男37例,女48例,平均年龄64.... 目的:分析特发性黄斑裂孔患者接受23G玻璃体手术治疗后黄斑结构的修复情况,以及视力和黄斑中央凹视网膜厚度的变化。方法:将2016-06/2017-12在我院进行择期手术的单眼特发性黄斑裂孔患者85例85眼纳入研究,其中男37例,女48例,平均年龄64. 7±10. 1岁。所有患者均接受23G玻璃体切割术,应用OCT观察术后黄斑裂孔闭合情况;应用OCT观察术前和术后1、3、6mo黄斑中央凹视网膜厚度的变化;观察术前和术后1、3、6mo患者最佳矫正视力的变化。结果:术后所有患者获得良好的黄斑裂孔闭合。术后3、6mo时所有患者平均最佳矫正视力显著高于术前和术后1mo(P<0. 05);术后6mo平均最佳矫正视力显著高于术后3mo,差异有统计学意义(t=7. 983,P=0. 037)。术后1mo黄斑中央凹视网膜厚度显著高于术前和术后3、6mo(P<0. 05);术后3、6mo的黄斑中央凹视网膜厚度显著低于术前(P<0. 05)。结论:应用23G玻璃体切除术治疗特发性黄斑裂孔具有较高的裂孔成功闭合率,患者的视力明显提高。 展开更多
关键词 特发性黄斑裂孔 23G玻璃体切割术 黄斑结构 最佳矫正视力 视网膜厚度
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特发性黄斑前膜患者内界膜剥除术后视功能的影响因素分析 被引量:4
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作者 刘华 孙佳 +1 位作者 赵霞 白领娣 《国际眼科杂志》 CAS 北大核心 2021年第9期1601-1606,共6页
目的:探讨影响特发性黄斑前膜患者内界膜剥除术后视功能恢复的危险因素。方法:回顾我院2016-01/2020-04收治的特发性黄斑前膜行视网膜内界膜剥除术的患者118例118眼。术后随访6mo评价手术疗效,观察术前、术后1、3、6mo的视力变化、视物... 目的:探讨影响特发性黄斑前膜患者内界膜剥除术后视功能恢复的危险因素。方法:回顾我院2016-01/2020-04收治的特发性黄斑前膜行视网膜内界膜剥除术的患者118例118眼。术后随访6mo评价手术疗效,观察术前、术后1、3、6mo的视力变化、视物变形程度、黄斑中心凹平均厚度、黄斑区容积。分析术前及术后黄斑中心凹平均厚度、黄斑区容积与术后视力及视物变形评分的相关性,评估术后视功能恢复不良的危险因素。结果:本组患者96眼视功能恢复良好,手术治疗改善率为81.4%。与术前相比,术后1、3、6mo术眼视力明显提升(P<0.05),水平方向视物变形评分明显缩小(P<0.05),术眼黄斑中心凹平均厚度、黄斑区容积明显减小(P<0.05)。术前与术后6mo黄斑中心凹平均厚度、黄斑区容积与术后6mo视力均呈负相关(P<0.05),与术后6mo水平方向视物变形评分均呈正相关(P<0.05)。IMEM病程、术前矫正视力、术前水平或垂直方向视物变形、术前黄斑水肿是患者术后视功能恢复情况的影响因素(均P<0.05),其中术前矫正视力差(OR=3.062)、术前存在水平方向视物变形(OR=2.438)、术前存在黄斑水肿(OR=2.000)是导致患者术后视功能恢复不良的危险因素。结论:内界膜剥除术治疗特发性黄斑前膜效果良好,可有效改善术眼视力,减轻视物变形。病程越长、术前矫正视力越差、术前视物变形越严重、术前有黄斑水肿的患者内界膜剥除术后视功能恢复越差。 展开更多
关键词 特发性黄斑前膜 内界膜剥除术 视力 视物变形 视功能
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Effects of Different Gravel Mulching on Soil Moisture Status and Regression Model Prediction in Arid Regions
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作者 Lingli zhao Hu zhao +1 位作者 xia zhao Liping Xin 《Journal of Geoscience and Environment Protection》 2022年第9期109-120,共12页
Drought is one of the main factors limiting the agricultural planting and production;gravel mulching is an effective inhibiting evaporation and water-saving planting pattern in the arid regions. In this study, experim... Drought is one of the main factors limiting the agricultural planting and production;gravel mulching is an effective inhibiting evaporation and water-saving planting pattern in the arid regions. In this study, experiments were conducted to study soil moisture effect and regression model with different gravel mulching, the soil moisture content and evaporation were compared that gravel mulched with different particle sizes, different thickness layer and different mulched years. The results showed that: 1) The cumulative soil evaporation of gravel mulched was only 29.3% of that bare fields. Mulching gravel could significantly reduce soil moisture evaporation. 2) The effects of inhibiting soil moisture evaporation are the best when mulch gravel thickness is 10 - 15 cm. 3) The particle size of gravel mulched is smaller, the evaporation inhibition effect will be better. Considering the water holding capacity and material economy, it is the most suitable to mulch gravel with the particle size of 3 - 5 cm. 4) Mulching gravel on the soil surface for 1 - 3 years can improve the soil moisture content. However, the gravel was mulched for more than five years, the soil moisture content decreased significantly. 5) The quadratic polynomial regression fitting model can better simulate and predict the cumulative evaporation on different gravel mulched, and the regression fitting degree R<sup>2</sup> is more than 0.98. 展开更多
关键词 Gravel Mulched EVAPORATION Thickness Particle Size Mulching Years Regression Fitting
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Application of Fractal Theory in Brick-Concrete Structural Health Monitoring
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作者 Changmin Yang xia zhao +1 位作者 Yanfang Yao Zhongqiang Zhang 《Engineering(科研)》 2016年第9期646-656,共12页
In order to monitor and forecast the deformation of the brick-concrete building, by taking a brick-concrete building as research object, fiber grating sensors were used to collect the monitoring data and double logari... In order to monitor and forecast the deformation of the brick-concrete building, by taking a brick-concrete building as research object, fiber grating sensors were used to collect the monitoring data and double logarithmic curve of limit value characteristic and monitoring data were obtained based on the fractal theory. Constant dimension fractal method cannot be used to analyze the data directly. With the method of variable dimension fractal, we accumulate data, and the double logarithmic curve is smooth. Piecewise fractal dimensions are close. The outer interpolation method is used to calculate the fractal dimension of the next point and then back calculate the vertical displacement. The relative errors are calculated by comparing the forecast values and monitoring values, and the maximum relative error is 5.76%. The result shows that the fractal theory is suitable to use in the forecast of the deformation and the accuracy is good. 展开更多
关键词 Brick-Concrete Building Real-Time Monitoring Fiber Grating Sensors Constant Di-mension Fractal Variable Dimension Fractal Log-Log Line Prediction
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工作记忆中整合物体和位置信息时的前额叶激活
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作者 张燕贞 xia zhao +2 位作者 Ai-Ling LIN Jia-Hong GAO 张学新 《中国医学影像技术》 CSCD 北大核心 2007年第6期837-840,共4页
目的利用功能磁共振成像(fMRI)技术研究了情节缓存中信息整合过程的脑机制。方法8名正常被试在MR扫描中执行工作记忆任务,“组合”(bound)条件下物体出现在外周某个位置,“未组合”(unbound)条件下,同时呈现一个位于中心的物体和一个在... 目的利用功能磁共振成像(fMRI)技术研究了情节缓存中信息整合过程的脑机制。方法8名正常被试在MR扫描中执行工作记忆任务,“组合”(bound)条件下物体出现在外周某个位置,“未组合”(unbound)条件下,同时呈现一个位于中心的物体和一个在外周某个位置的十字,让被试将物体想象到十字所在位置,要求被试判断再次出现的物体是否在曾经见过的位置(“组合”条件)或曾经想象过的位置(“未组合”条件)。结果“未组合”条件相对于知觉“组合”条件,在双侧额中回/额下回、顶叶和小脑等区域出现了显著激活;“组合”条件相对于"未组合”条件没有任何激活。结论本研究表明前额叶皮层在没有知觉表征情况下建立新的整合表征中具有重要作用。现有研究已证明前额叶皮层在建构和保持整合信息中的作用,本文进一步的研究提示它可能是情节缓存中信息整合的神经基础。 展开更多
关键词 情节缓存 工作记忆 整合 前额叶皮层 磁共振成像 功能性
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血清和透出液sICAM-1、PCT、CA125与腹膜透析相关细菌性腹膜炎的关系及预测价值 被引量:4
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作者 刘盼盼 张东成 +4 位作者 赵霞 仲思 郭馨 秦丽丽 胡晔 《中国现代医学杂志》 CAS 北大核心 2022年第3期48-54,共7页
目的探讨血清和透出液可溶性细胞间黏附分子-1(sICAM-1)、降钙素原(PCT)、糖类抗原125(CA125)与腹膜透析相关细菌性腹膜炎的关系,以及其预测腹膜透析相关细菌性腹膜炎的价值。方法选取辽宁省人民医院肾病学科2017年1月—2019年6月疑似... 目的探讨血清和透出液可溶性细胞间黏附分子-1(sICAM-1)、降钙素原(PCT)、糖类抗原125(CA125)与腹膜透析相关细菌性腹膜炎的关系,以及其预测腹膜透析相关细菌性腹膜炎的价值。方法选取辽宁省人民医院肾病学科2017年1月—2019年6月疑似腹膜透析相关细菌性腹膜炎119例患者作为研究对象。根据临床诊断结果分为研究组(有细菌性腹膜炎者66例)与对照组(无细菌性腹膜炎者53例)。比较两组血清和透出液sICAM-1、PCT、CA125水平,并探究各指标对腹膜透析相关细菌性腹膜炎的预测价值。研究组给予抗感染治疗,比较治疗后感染控制者与未控制者血清、透出液sICAM-1、PCT、CA125水平。结果研究组血清和透出液sICAM-1、PCT、CA125水平高于对照组(P <0.05);血清sICAM-1水平[OR=1.123(95%CI:1.051,1.200)]、透出液sICAM-1水平[OR=2.006(95%CI:1.352,2.975)]、血清PCT水平[OR=2.134(95%CI:1.292,3.525)]、透出液PCT水平[OR=3.025(95%CI:1.628,5.621)]及透出液CA125水平[OR=1.227(95%CI:1.065,1.414)]均是腹膜透析细菌性腹膜炎的危险因素(P <0.05);血清sICAM-1、PCT联合预测腹膜透析细菌性腹膜炎的曲线下面积(AUC)为0.898(95%CI:0.829,0.946),大于血清sICAM-1单独预测的AUC 0.750(95%CI:0.662,0.824)和血清PCT单独预测的AUC 0.810(95%CI:0.728,0.876),联合预测的敏感性为84.85%(95%CI:0.734,0.921)、特异性为84.91%(95%CI:0.719,0.928);透出液sICAM-1、PCT、CA125联合预测腹膜透析细菌性腹膜炎的AUC为0.926(95%CI:0.863,0.966),大于透出液sICAM-1单独预测的AUC 0.798(95%CI:0.714,0.866)、透出液PCT单独预测的AUC 0.819(95%CI:0.738,0.884)及透出液CA125单独预测的AUC 0.794(95%CI:0.711,0.863),联合预测的敏感性为86.36%(95%CI:0.752,0.932)、特异性为88.68%(95%CI:0.763,0.953);感染控制者血清和透出液sICAM-1、PCT及透出液CA125水平均低于感染未控制者(P <0.05)。结论随着血清和透出液sICAM-1、PCT及透出液CA125水平的升高,腹膜透析相关细菌性腹膜炎的发生风险增加,各指标对腹膜透析细菌性腹膜炎具有预测价值,且能辅助临床评估感染控制情况。 展开更多
关键词 细菌性腹膜炎 腹膜透析 可溶性细胞间黏附分子-1 降钙素原 糖类抗原125 感染控制
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小驳骨乙酸乙酯部位的化学成分研究 被引量:3
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作者 张海新 夏召 +2 位作者 许天启 陈宜敏 周光雄 《天然产物研究与开发》 CAS CSCD 北大核心 2020年第7期1148-1155,共8页
研究小驳骨(Justicia gendarussa Burm.f.)中乙酸乙酯部位的化学成分。综合运用反复硅胶柱色谱、ODS开放柱、凝胶柱色谱、反相半制备型HPLC,对小驳骨的95%乙醇提取物中乙酸乙酯部位的化学成分进行分离纯化,并通过HR-ESI-MS、NMR等光谱... 研究小驳骨(Justicia gendarussa Burm.f.)中乙酸乙酯部位的化学成分。综合运用反复硅胶柱色谱、ODS开放柱、凝胶柱色谱、反相半制备型HPLC,对小驳骨的95%乙醇提取物中乙酸乙酯部位的化学成分进行分离纯化,并通过HR-ESI-MS、NMR等光谱数据及X射线单晶衍射共鉴定了21个化合物的结构,分别为2,3,3a,5-四氢-1H-苯并[d]吡咯并[2,1-b][1,3]恶嗪-1-酮(1)、4′-羟基苯乙酮(2)、apocynin(3)、白首乌二苯酮(4)、对羟基苯甲醛(5)、水杨酸(6)、2,4-二羟基苯乙酮(7)、2,5-二羟基苯乙酮(8)、1,3,5-三甲氧基苯(9)、丁香酮(10)、壬二酸(11)、(+)-松脂素-O-β-D-吡喃葡萄糖苷(12)、corchoionoside C(13)、patuletin-3-O-glucoside(14)、commicarpiflavonol glucoside A(15)、1,2,3-三甲氧基-5-硝基苯(16)、4-硝基苯酚(17)、单油酸甘油酯(18)、tetradecanoate(19)、硬脂酸(20)、棕榈酸(21)。化合物1、16为新天然产物,所有化合物均首次从该植物中分离得到。对从中分离得到的单体化合物进行抗炎活性的筛选,其中,槲皮素作为阳性药,其IC50值为16.94±0.40μM。化合物4、6、8具有显著的抗炎活性,其值均小于16.94±0.40μM。 展开更多
关键词 小驳骨 乙酸乙酯部位 X射线衍射 抗炎活性
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地塞米松玻璃体内植入剂治疗难治性非感染性葡萄膜炎的有效性与安全性 被引量:13
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作者 陈青山 梁思颖 +4 位作者 赵霞 胡晨丽 阳铭 陈妙虹 曾平 《国际眼科杂志》 CAS 北大核心 2021年第6期1096-1100,共5页
目的:观察地塞米松玻璃体内植入剂(Ozurdex)治疗难治性非感染性葡萄膜炎的有效性和安全性及其对全身糖皮质激素和免疫抑制剂使用剂量的影响。方法:回顾性系列病例研究。纳入2018-01/2019-09确诊为难治性非感染性葡萄膜炎并采用地塞米松... 目的:观察地塞米松玻璃体内植入剂(Ozurdex)治疗难治性非感染性葡萄膜炎的有效性和安全性及其对全身糖皮质激素和免疫抑制剂使用剂量的影响。方法:回顾性系列病例研究。纳入2018-01/2019-09确诊为难治性非感染性葡萄膜炎并采用地塞米松玻璃体内植入剂治疗的患者19例21眼,观察地塞米松玻璃体内植入剂治疗后1、2、4、6mo患者的最佳矫正视力(BCVA,LogMAR)、中央视网膜厚度(CRT)、炎性玻璃体混浊评分、全身使用糖皮质激素和免疫抑制剂剂量,并与基线进行比较。结果:研究眼基线平均BCVA 0.671±0.469,CRT 369.667±177.100μm,眼压14.26±3.44mmHg。地塞米松玻璃体内植入剂治疗1、2、4、6mo后BCVA较基线显著改善(P<0.05)、CRT较基线降低(P<0.05)、玻璃体混浊评分显著降低(P<0.05)。随访期间,部分患者眼压较基线升高,但末次随访所有患者眼压均在正常值范围。基线时,患者6例6眼口服醋酸泼尼松治疗,平均剂量为35.8mg/d;随访6mo时,仅2例患者需口服醋酸泼尼松(平均剂量为5mg/d)。除3例白塞病患者在4~6mo期间黄斑水肿复发外,其余患者随访至6mo均未复发。结论:地塞米松玻璃体内植入剂治疗非感染性难治性葡萄膜炎安全有效,可显著改善视力,减轻黄斑水肿,减轻玻璃体炎症,减少系统性糖皮质激素使用剂量。 展开更多
关键词 地塞米松玻璃体内植入剂 非感染性葡萄膜炎 难治性 有效性 安全性
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Comparison of machine learning models for gully erosion susceptibility mapping 被引量:8
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作者 Alireza Arabameri Wei Chen +6 位作者 Marco Loche xia zhao Yang Li Luigi Lombardo Artemi Cerda Biswajeet Pradhan Dieu Tien Bui 《Geoscience Frontiers》 SCIE CAS CSCD 2020年第5期1609-1620,共12页
Gully erosion is a disruptive phenomenon which extensively affects the Iranian territory,especially in the Northern provinces.A number of studies have been recently undertaken to study this process and to predict it o... Gully erosion is a disruptive phenomenon which extensively affects the Iranian territory,especially in the Northern provinces.A number of studies have been recently undertaken to study this process and to predict it over space and ultimately,in a broader national effort,to limit its negative effects on local communities.We focused on the Bastam watershed where 9.3%of its surface is currently affected by gullying.Machine learning algorithms are currently under the magnifying glass across the geomorphological community for their high predictive ability.However,unlike the bivariate statistical models,their structure does not provide intuitive and quantifiable measures of environmental preconditioning factors.To cope with such weakness,we interpret preconditioning causes on the basis of a bivariate approach namely,Index of Entropy.And,we performed the susceptibility mapping procedure by testing three extensions of a decision tree model namely,Alternating Decision Tree(ADTree),Naive-Bayes tree(NBTree),and Logistic Model Tree(LMT).We dichotomized the gully information over space into gully presence/absence conditions,which we further explored in their calibration and validation stages.Being the presence/absence information and associated factors identical,the resulting differences are only due to the algorithmic structures of the three models we chose.Such differences are not significant in terms of performances;in fact,the three models produce outstanding predictive AUC measures(ADTree=0.922;NBTree=0.939;LMT=0.944).However,the associated mapping results depict very different patterns where only the LMT is associated with reasonable susceptibility patterns.This is a strong indication of what model combines best performance and mapping for any natural hazard-oriented application. 展开更多
关键词 Oil erosion GIS Alternating decision tree model Logistic model tree model
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Developing polydopamine modified molybdenum disulfide/epoxy resin powder coatings with enhanced anticorrosion performance and wear resistance on magnesium lithium alloys 被引量:4
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作者 Shibo Chen Changqing Yin +8 位作者 Yi Wang Shuang Yi xiang Gao Xujuan Zhang Qiyu Liao Yuxin Zhang xia zhao Jinsong Rao Baorong Hou 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2022年第9期2534-2545,共12页
Epoxy resin powder coating has been successfully applied on the corrosion protection of magnesium lithium alloys.However,poor wear resistance and microcracks formed during the solidification have limited it extensive ... Epoxy resin powder coating has been successfully applied on the corrosion protection of magnesium lithium alloys.However,poor wear resistance and microcracks formed during the solidification have limited it extensive application.There are limited approaches to exploit such anti-corrosion and mechanical properties of magnesium lithium alloys.Herein,the epoxy resin powder coating with polydopamine modified molybdenum disulfide(MoS_(2)@PDA-EP powder coating with 0,0.1,0.2,0.5,1.0 wt.%loading)was well prepared by melt extrusion to investigate its anticorrosion performance and wear resistance.The results revealed that the addition of MoS_(2)@PDA enhanced the adhesion strength between coatings and alloys,wear resistance and corrosion protection of the powder coatings.Among them,the optimum was obtained by 0.2 wt.%MoS_(2)@PDA-EP powder coating which could be attributed to well dispersion and efficient adhesion with coating matrix.To conclude,MoS_(2)@PDA-EP powder coating is meaningfully beneficial for the anticorrosive and wear performance improvement of magnesium lithium alloys. 展开更多
关键词 Magnesium lithium alloys Epoxy resin powder coating Molybdenum disulfide POLYDOPAMINE Anticorrosion performance Wear resistance
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Experimental and density functional theory computational evaluation of poly(N-vinyl caprolactam-co-butyl methacrylate) kinetic hydrate inhibitors 被引量:2
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作者 Yanping Duan Pengfei Wang +4 位作者 Wenge Yang xia zhao Hong Hao Ruijie Wu Jie Huang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第12期237-244,共8页
Natural gas hydrate inhibitor has been serving the oil and gas industry for many years. The development and search for new inhibitors remain the focus of research. In this study, the solution polymerization method was... Natural gas hydrate inhibitor has been serving the oil and gas industry for many years. The development and search for new inhibitors remain the focus of research. In this study, the solution polymerization method was employed to prepare poly(N-vinyl caprolactam-co-butyl methacrylate)(P(VCap-BMA)), as a new kinetic hydrate inhibitor(KHI). The inhibition properties of P(VCap-BMA) were investigated by tetrahydrofuran(THF) hydrate testing and natural gas hydrate forming and compared with the commercial KHIs. The experiment showed that PVCap performed better than copolymer P(VCap-BMA). However,low doses of methanol or ethylene glycol are compounded with KHIs. The compounding inhibitors show a synergistic inhibitory effect. More interesting is the P(VCap-BMA)-methanol system has a better inhibitory effect than the PVCap-methanol system. 1% P(VCap-BMA) + 5% methanol presented the best inhibiting performance at subcooling 10.3 °C, the induction time of natural gas hydrate was 445 min.Finally, the interaction between water and several dimeric inhibitors compared by natural bond orbital(NBO) analyses and density functional theory(DFT) indicated that inhibitor molecules were able to form the hydrogen bond with the water molecules, which result in gas hydrate inhibition. These exciting properties make the P(VCap-BMA) compound hydrate inhibitor promising candidates for numerous applications in the petrochemical industry. 展开更多
关键词 Kinetic hydrate inhibitors Synthesis Poly(N-vinylcaprolactam-co-butyl methacrylate) Natural gas HYDRATE Computer simulation
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Role of the Oceanic Channel in the Relationships between the Basin/Dipole Mode of SST Anomalies in the Tropical Indian Ocean and ENSO Transition 被引量:2
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作者 xia zhao Dongliang YUAN +2 位作者 Guang YANG Hui ZHOU Jing WANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2016年第12期1386-1400,共15页
The relationships between the tropical Indian Ocean basin (IOB)/dipole (IOD) mode of SST anomalies (SSTAs) and ENSO phase transition during the following year are examined and compared in observations for the pe... The relationships between the tropical Indian Ocean basin (IOB)/dipole (IOD) mode of SST anomalies (SSTAs) and ENSO phase transition during the following year are examined and compared in observations for the period 1958-2008. Both partial correlation analysis and composite analysis show that both the positive (negative) phase of the lOB and IOD (independent of each other) in the tropical Indian Ocean are possible contributors to the E1 Nino (La Nifia) decay and phase transition to La Nifia (El Nifio) about one year later. However, the influence on ENSO transition induced by the IOB is stronger than that by the IOD. The SSTAs in the equatorial central-eastern Pacific in the coming year originate from subsurface temperature anomalies in the equatorial eastern Indian and western Pacific Ocean, induced by the IOB and IOD through eastward and upward propagation to meet the surface. During this process, however the contribution of the oceanic channel process between the tropical Indian and Pacific oceans is totally different for the IOB and IOD. For the IOD, the influence of the Indonesian Throughflow transport anomalies could propagate to the eastern Pacific to induce the ENSO transition. For the IOB, the impact of the oceanic channel stays and disappears in the western Pacific without propagation to the eastern Pacific. 展开更多
关键词 Indian Ocean SSTAs dipole mode basin mode ENSO transition oceanic channel
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Technology of structure damage monitoring based on multi-agent 被引量:2
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作者 Hongbing Sun Shenfang Yuan +2 位作者 xia zhao Hengbao Zhou Dong Liang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2010年第4期616-622,共7页
The health monitoring for large-scale structures need to resolve a large number of difficulties,such as the data transmission and distributing information handling.To solve these problems,the technology of multi-agent... The health monitoring for large-scale structures need to resolve a large number of difficulties,such as the data transmission and distributing information handling.To solve these problems,the technology of multi-agent is a good candidate to be used in the field of structural health monitoring.A structural health monitoring system architecture based on multi-agent technology is proposed.The measurement system for aircraft airfoil is designed with FBG,strain gage,and corresponding signal processing circuit.The experiment to determine the location of the concentrate loading on the structure is carried on with the system combined with technologies of pattern recognition and multi-agent.The results show that the system can locate the concentrate loading of the aircraft airfoil at the accuracy of 91.2%. 展开更多
关键词 structural health monitoring multi-agent technology flexible transmission collaboration.
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