Long non-coding RNAs （lncRNAs） are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames （ORFs） [1-4]. In contrast to small non-coding RNAs （ncRNAs）, such as microRNAs...Long non-coding RNAs （lncRNAs） are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames （ORFs） [1-4]. In contrast to small non-coding RNAs （ncRNAs）, such as microRNAs （miR- NAs） [4-23], small interfering RNAs （siRNAs） [24-31] and transfer RNAs （tRNAs） [32-34], there are thousands of IncRNA genes discovered during the past three years in the human genome and most of their functions remain elusive. The long nucleotide chain of lncRNAs can either form a complex spatial structure and interact with protein factors, or provide a large segment for the concurrent binding of many molecules that collectively participate in genomic imprinting, X-chromosome silencing, chromosome modifi- cation, intranuclear transport, transcriptional activation and interference, thereby regulating cell growth, differentiation, development, senescence and death [35].展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 30971147, 81071644, 81172189, 81171930, 81272255,81272297, 81272298 and 91229122)the Hunan Province Natural Science Foundation of China (Grant No. 10JJ7003)+3 种基金the Fok Ying Tong Education Foundation (Grant No. 121036)the Fundamental Research Funds for the Central Universities (Grant No. 2011JQ020)the Mittal Innovative Entre-preneurial Project of Central South University (Grant No. 11MX27)the Open-End Fund for the Valuable and Precision Instruments of Central South University and the Postdoctoral Science Foundation of Central South University
文摘Long non-coding RNAs （lncRNAs） are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames （ORFs） [1-4]. In contrast to small non-coding RNAs （ncRNAs）, such as microRNAs （miR- NAs） [4-23], small interfering RNAs （siRNAs） [24-31] and transfer RNAs （tRNAs） [32-34], there are thousands of IncRNA genes discovered during the past three years in the human genome and most of their functions remain elusive. The long nucleotide chain of lncRNAs can either form a complex spatial structure and interact with protein factors, or provide a large segment for the concurrent binding of many molecules that collectively participate in genomic imprinting, X-chromosome silencing, chromosome modifi- cation, intranuclear transport, transcriptional activation and interference, thereby regulating cell growth, differentiation, development, senescence and death [35].
