Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of Science,PubMed,and Embase between January 1...Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of Science,PubMed,and Embase between January 1980 and September 2022 was systematically searched.Meta-analyses of the genetic variants were conducted using at least five data sources.The epidemiologic credibility of the significant associations was graded using the Venice criteria.Results Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing studies.We identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the meta-analysis.The meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.展开更多
Plastic scintillators(PSs)embedded with wavelength-shifting fibers are widely used in high-energy particle physics,such as in muon taggers,as well as in medical physics and other applications.In this study,a simulatio...Plastic scintillators(PSs)embedded with wavelength-shifting fibers are widely used in high-energy particle physics,such as in muon taggers,as well as in medical physics and other applications.In this study,a simulation package was built to evaluate the effects of the diameter and layout of optical fibers on the light yield with different configurations.The optimal optical configuration was designed based on simulations and validated using two PS prototypes under certain experimental condi-tions.A top veto tracker(TVT)for the JUNO-TAO experiment,comprising four layers of 160 strips of PS,was designed and evaluated.The threshold was evaluated when the muon tagging efficiency of a PS strip was>99%.The efficiency of three layer out of four layer of TVT is>99%,even with a tagging efficiency of a single strip as low as 97%,using a threshold of 10 photoelectrons and assuming a 40%silicon PM photon detection efficiency.展开更多
Recent reactor antineutrino experiments have observed that the neutrino spectrum changes with the reactor core evolution and that the individual fissile isotope antineutrino spectra can be decomposed from the evolving...Recent reactor antineutrino experiments have observed that the neutrino spectrum changes with the reactor core evolution and that the individual fissile isotope antineutrino spectra can be decomposed from the evolving data,providing valuable information for the reactor model and data inconsistent problems.We propose a machine learning method by building a convolutional neural network based on a virtual experiment with a typical short-baseline reactor antineutrino experiment configuration:by utilizing the reactor evolution information,the major fissile isotope spectra are correctly extracted,and the uncertainties are evaluated using the Monte Carlo method.Validation tests show that the method is unbiased and introduces tiny extra uncertainties.展开更多
基金supported by grants from the National Natural Science Foundation of China[No.81872641]Natural Science Foundation of Hunan Province[No.2023JJ40357].
文摘Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods Literature from Web of Science,PubMed,and Embase between January 1980 and September 2022 was systematically searched.Meta-analyses of the genetic variants were conducted using at least five data sources.The epidemiologic credibility of the significant associations was graded using the Venice criteria.Results Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing studies.We identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the meta-analysis.The meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.
基金supported by the School of Physics at Sun Yat-sen University,China
文摘Plastic scintillators(PSs)embedded with wavelength-shifting fibers are widely used in high-energy particle physics,such as in muon taggers,as well as in medical physics and other applications.In this study,a simulation package was built to evaluate the effects of the diameter and layout of optical fibers on the light yield with different configurations.The optimal optical configuration was designed based on simulations and validated using two PS prototypes under certain experimental condi-tions.A top veto tracker(TVT)for the JUNO-TAO experiment,comprising four layers of 160 strips of PS,was designed and evaluated.The threshold was evaluated when the muon tagging efficiency of a PS strip was>99%.The efficiency of three layer out of four layer of TVT is>99%,even with a tagging efficiency of a single strip as low as 97%,using a threshold of 10 photoelectrons and assuming a 40%silicon PM photon detection efficiency.
基金supported by the National Natural Science Foundation of China (Nos.11675273 and 12075087)the Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDA10011102)。
文摘Recent reactor antineutrino experiments have observed that the neutrino spectrum changes with the reactor core evolution and that the individual fissile isotope antineutrino spectra can be decomposed from the evolving data,providing valuable information for the reactor model and data inconsistent problems.We propose a machine learning method by building a convolutional neural network based on a virtual experiment with a typical short-baseline reactor antineutrino experiment configuration:by utilizing the reactor evolution information,the major fissile isotope spectra are correctly extracted,and the uncertainties are evaluated using the Monte Carlo method.Validation tests show that the method is unbiased and introduces tiny extra uncertainties.
