Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the pathogen of the ongoing coronavirus disease 2019(COVID-19)global pandemic.Here,by centralizing published cell-based experiments,clinical trials,and vir...Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the pathogen of the ongoing coronavirus disease 2019(COVID-19)global pandemic.Here,by centralizing published cell-based experiments,clinical trials,and virtual drug screening data from the NCBI PubMed database,we developed a database of SARS-CoV-2 inhibitors for COVID-19,dbSCI,which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments,81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses.dbSCI provides four major functions:(1)search the drug target or its inhibitor for SARS-CoV-2,(2)browse target/inhibitor information collected from cell experiments,clinical trials,and virtual drug screenings,(3)download,and(4)submit data.Each entry in dbSCI contains 18 types of information,including inhibitor/drug name,targeting protein,mechanism of inhibition,experimental technique,experimental sample type,and reference information.In summary,dbSCI provides a relatively comprehensive,credible repository for inhibitors/drugs against SARS-CoV-2 and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19.展开更多
Tumor microenvironment(TME)is the environment around the tumor cells,consisting of extracellular matrix,nonmalignant stromal cells,and various types of immune cells(like macrophages,B and T lymphocytes).1 TME has been...Tumor microenvironment(TME)is the environment around the tumor cells,consisting of extracellular matrix,nonmalignant stromal cells,and various types of immune cells(like macrophages,B and T lymphocytes).1 TME has been recurrently reported to play important roles in the progression of cancers.1 The mechanism study of TME may offer opportunities for targeted/immune therapies.However,how TME components impact the prognosis of cancer patients remains to be determined.展开更多
Head and neck squamous cell carcinoma(HNSCC),as the most common type(>90%)of head and neck cancer,includes various epithelial malignancies that arise in the nasal cavity,oral cavity,pharynx,and larynx.In 2020,appro...Head and neck squamous cell carcinoma(HNSCC),as the most common type(>90%)of head and neck cancer,includes various epithelial malignancies that arise in the nasal cavity,oral cavity,pharynx,and larynx.In 2020,approximately 878000 new cases and 444000 deaths linked to HNSCC occurred worldwide(Sung et al.,2021).Due to the associated frequent recurrence and metastasis.展开更多
We define the Whittaker modules over the simply-connected quantum group U_(q)(sl3,∧),where A is the weight lattice of Lie algebra sl3.Then we completely classify all those simple ones.Explicitly,a simple Whittaker mo...We define the Whittaker modules over the simply-connected quantum group U_(q)(sl3,∧),where A is the weight lattice of Lie algebra sl3.Then we completely classify all those simple ones.Explicitly,a simple Whittaker module over U_(q)(sl3,∧)is either a highest weight module,or determined by two parameters z∈C andγ∈C^(*)(up to a Hopf automorphism).展开更多
基金supported by the Innovation and Entrepreneurship Training Program for College Students in Henan University(20221022009)the Key Scientific Research Project of Henan Province(22A310012)+1 种基金supporting program for Central Plain Young Top Talents(ZYQR201912176)the program from Academy for Advanced Interdisciplinary Studies of Henan University(Y21008L).
文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the pathogen of the ongoing coronavirus disease 2019(COVID-19)global pandemic.Here,by centralizing published cell-based experiments,clinical trials,and virtual drug screening data from the NCBI PubMed database,we developed a database of SARS-CoV-2 inhibitors for COVID-19,dbSCI,which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments,81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses.dbSCI provides four major functions:(1)search the drug target or its inhibitor for SARS-CoV-2,(2)browse target/inhibitor information collected from cell experiments,clinical trials,and virtual drug screenings,(3)download,and(4)submit data.Each entry in dbSCI contains 18 types of information,including inhibitor/drug name,targeting protein,mechanism of inhibition,experimental technique,experimental sample type,and reference information.In summary,dbSCI provides a relatively comprehensive,credible repository for inhibitors/drugs against SARS-CoV-2 and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19.
基金supported by the key scientific research project of Henan Province,China(No.22A310012)National Natural Science Foundation of China(No.U2004136)+2 种基金supporting program for Central Plain Young Top Talents(China)(No.ZYQR201912176)a program from academy for advanced interdisciplinary studies of Henan University,Henan,China(No.CX3070A0970005)innovative technology team of big data on tumor prognosis in Kaifeng,and key project of undergraduate Teaching Reform Research and Practice project of Henan University in 2020.
文摘Tumor microenvironment(TME)is the environment around the tumor cells,consisting of extracellular matrix,nonmalignant stromal cells,and various types of immune cells(like macrophages,B and T lymphocytes).1 TME has been recurrently reported to play important roles in the progression of cancers.1 The mechanism study of TME may offer opportunities for targeted/immune therapies.However,how TME components impact the prognosis of cancer patients remains to be determined.
基金This work was supported by the National Natural Science Foundation of China(No.U2004136)the Supporting Program for Central Plain Young Top Talents(No.ZYQR201912176),the Program for Innovative Talents of Science and Technology in Henan Province(No.18HASTIT048)+2 种基金the Program for Science and Technology Development in Henan Province(Nos.212102310150,202102310063,and SBGJ2018041)the Kaifeng Science and Technology Project(No.1908001)the Supporting Grant of Henan University(Nos.2018YLJC01,2019YLXKJC01,and 2020YLZDYJ14),China.
文摘Head and neck squamous cell carcinoma(HNSCC),as the most common type(>90%)of head and neck cancer,includes various epithelial malignancies that arise in the nasal cavity,oral cavity,pharynx,and larynx.In 2020,approximately 878000 new cases and 444000 deaths linked to HNSCC occurred worldwide(Sung et al.,2021).Due to the associated frequent recurrence and metastasis.
基金the National Natural Science Foundation of China(Grant Nos.11971440,11871249,11771142,11931009)the Jiangsu Natural Science Foundation(No.BK20171294).
文摘We define the Whittaker modules over the simply-connected quantum group U_(q)(sl3,∧),where A is the weight lattice of Lie algebra sl3.Then we completely classify all those simple ones.Explicitly,a simple Whittaker module over U_(q)(sl3,∧)is either a highest weight module,or determined by two parameters z∈C andγ∈C^(*)(up to a Hopf automorphism).
