受阻路易斯酸碱对(frustrated Lewis pairs,FLPs)是大位阻的路易斯酸和大位阻的路易斯碱在溶液中受空间位阻因素影响而不能形成配位键所得到的组合。在这种特殊的组合中,路易斯酸和路易斯碱未能被中和淬灭,依旧保持着的反应活性。而当H_...受阻路易斯酸碱对(frustrated Lewis pairs,FLPs)是大位阻的路易斯酸和大位阻的路易斯碱在溶液中受空间位阻因素影响而不能形成配位键所得到的组合。在这种特殊的组合中,路易斯酸和路易斯碱未能被中和淬灭,依旧保持着的反应活性。而当H_2等小分子靠近时,FLPs可以将H_2的化学键异裂,进而得到一个阳离子和一个阴离子。这种独特的反应特性使得FLPs在催化加氢、小分子气体活化、烯烃聚合和开环聚合等方面展现出了一些具有新特性的研究思想和方法。尤其是在烯烃聚合和开环聚合中,FLPs具有很强的催化活性。本文简要介绍了FLPs的发展历史及其在小分子活化中的应用,并重点介绍了其在高分子催化领域中的应用。展开更多
Intelligent polymers or stimuli-responsive polymers may exhibit distinct transitions in physical-chemical properties, including conformation, polarity, phase structure and chemical composition in response to changes i...Intelligent polymers or stimuli-responsive polymers may exhibit distinct transitions in physical-chemical properties, including conformation, polarity, phase structure and chemical composition in response to changes in environmental stimuli. Due to their unique 'intelligent' characteristics, stimuli-sensitive polymers have found a wide variety of applications in biomedical and nanotechnological fields. This review focuses on the recent developments in biomedical application of intelligent polymer systems, such as intelligent hydrogel systems, intelligent drug delivery systems and intelligent molecular recognition systems. Also, the possible future directions for the application of these intelligent polymer systems in the biomedical field are presented.展开更多
A series of well-defined amphiphilic linear-dendritic block copolymers （telodendrimers, MPEG-b-PAMAM-cholesterol） with 1,2,4 or 8 cholesteryl groups （named as P1, P2, P4, P8, respectively） were synthesized. Their ...A series of well-defined amphiphilic linear-dendritic block copolymers （telodendrimers, MPEG-b-PAMAM-cholesterol） with 1,2,4 or 8 cholesteryl groups （named as P1, P2, P4, P8, respectively） were synthesized. Their chemical structures were char- acterized with IH NMR and mass spectrum （MALDI-TOF MS）. The telodendrimers could self-assemble into micelles in aqueous solution, and encapsulate chemotherapeutic drug doxorubicin （DOX） and paclitaxel （PTX） for combination therapy. All the telodendrimers could encapsulate DOX with similar capability. However, their drug-loading capability of PTX is in- creased with the increasing number of cholesteryl groups. P8 exhibited much higher PTX loading efficiency than its counter- parts. Thus, P8 was selected for further application of drug delivery in the paper. The drug-loading micellar nanoparticles （NPs） of P8 were spherical in shape and their diameters were less than 150 nm which were determined by dynamic light scattering measurements （DLS） and transmission electron microscope （TEM）. In vitro drug release experiment demonstrated that P8 ex- hibited a controlled release manner for both DOX and PTX, and the two drugs were released simultaneously. In vitro cytotoxi- city experiment further demonstrated that the co-delivery of DOX and PTX in P8 exhibited better anti-cancer efficiency than the delivery systems encapsulated with single drug （DOX or PTX）. This indicates a synergistic effect. The co-delivery system showed potential in future anti-cancer treatment.展开更多
Ill tliis work, two kinds of PEGylated salicylaldehyde azine(SA) polymers were prepared and investigated for cellular imaging applications. First, a diazido derivative of SA was synthesized and subsequently PEGylated ...Ill tliis work, two kinds of PEGylated salicylaldehyde azine(SA) polymers were prepared and investigated for cellular imaging applications. First, a diazido derivative of SA was synthesized and subsequently PEGylated with polyethylene glycol monomethyl ether(mPEG) by metal-free azide-alkyne 1,3-dipolar cycloaddition reaction. The formed triazole group in niPEG-SA was then converted into cationic triazolium group by N-alkylation reaction. Botli the synthesized polymers, niPEG-SA and N-alkylated niPEG-SA, showed good dispersibility in water, but differences in self-assembly of nanostructures. The niPEG-SA with triazole groups self-assembled into micelles, while the N-alkylated mPEG-SA with triazolium groups sell-assembled into vesicles. Furthemiore, mPEG-SA and N-alkylated niPEG?SA naiioparticles showed bright fluorescence due to the aggregation of AIE-active SA molecules in the nanoparticles and could be successfully used as fluorescent naiioprobes for bioimaging applications in HeLa cancer cells. Finally, both the synthesized polymers showed minimal cytotoxicity and low hemolytic activity. Therefore, these PEGylated SA polymers proved to be promising bioimaging nanoprobes or traceable dnig delivery vehicles.展开更多
文摘受阻路易斯酸碱对(frustrated Lewis pairs,FLPs)是大位阻的路易斯酸和大位阻的路易斯碱在溶液中受空间位阻因素影响而不能形成配位键所得到的组合。在这种特殊的组合中,路易斯酸和路易斯碱未能被中和淬灭,依旧保持着的反应活性。而当H_2等小分子靠近时,FLPs可以将H_2的化学键异裂,进而得到一个阳离子和一个阴离子。这种独特的反应特性使得FLPs在催化加氢、小分子气体活化、烯烃聚合和开环聚合等方面展现出了一些具有新特性的研究思想和方法。尤其是在烯烃聚合和开环聚合中,FLPs具有很强的催化活性。本文简要介绍了FLPs的发展历史及其在小分子活化中的应用,并重点介绍了其在高分子催化领域中的应用。
基金Supported by the National Natural Science Foundation of China (Grant Nos.20604028, 50573078, and 50733003)National Fund for Distinguished Young Scholar (Grant No. 50425309)+1 种基金A3 Foresight Program of the National Natural Science Foundation of China (Grant No. 20621140369)Key International Science and Technology Cooperation Project of Ministry of Science and Technology of China (Grant No. 20071314)
文摘Intelligent polymers or stimuli-responsive polymers may exhibit distinct transitions in physical-chemical properties, including conformation, polarity, phase structure and chemical composition in response to changes in environmental stimuli. Due to their unique 'intelligent' characteristics, stimuli-sensitive polymers have found a wide variety of applications in biomedical and nanotechnological fields. This review focuses on the recent developments in biomedical application of intelligent polymer systems, such as intelligent hydrogel systems, intelligent drug delivery systems and intelligent molecular recognition systems. Also, the possible future directions for the application of these intelligent polymer systems in the biomedical field are presented.
基金support from the National Natural Science Foundation of China(51233004,51273196,51203153,51021003 and 51303174)the Ministry of Science and Technology of China(international cooperation program 2011DFR51090)Jilin province science and technology development program(20130521011JH)
文摘A series of well-defined amphiphilic linear-dendritic block copolymers （telodendrimers, MPEG-b-PAMAM-cholesterol） with 1,2,4 or 8 cholesteryl groups （named as P1, P2, P4, P8, respectively） were synthesized. Their chemical structures were char- acterized with IH NMR and mass spectrum （MALDI-TOF MS）. The telodendrimers could self-assemble into micelles in aqueous solution, and encapsulate chemotherapeutic drug doxorubicin （DOX） and paclitaxel （PTX） for combination therapy. All the telodendrimers could encapsulate DOX with similar capability. However, their drug-loading capability of PTX is in- creased with the increasing number of cholesteryl groups. P8 exhibited much higher PTX loading efficiency than its counter- parts. Thus, P8 was selected for further application of drug delivery in the paper. The drug-loading micellar nanoparticles （NPs） of P8 were spherical in shape and their diameters were less than 150 nm which were determined by dynamic light scattering measurements （DLS） and transmission electron microscope （TEM）. In vitro drug release experiment demonstrated that P8 ex- hibited a controlled release manner for both DOX and PTX, and the two drugs were released simultaneously. In vitro cytotoxi- city experiment further demonstrated that the co-delivery of DOX and PTX in P8 exhibited better anti-cancer efficiency than the delivery systems encapsulated with single drug （DOX or PTX）. This indicates a synergistic effect. The co-delivery system showed potential in future anti-cancer treatment.
基金Supported by the National Natural Science Foundation of China(Nos.51573184,51520105004)the Science and Teclmology Development Program of Jilin Province,China(No.2019010322JH)the Fund of Youth Innovation Promotion Association of CAS,China(No.2017266).
文摘Ill tliis work, two kinds of PEGylated salicylaldehyde azine(SA) polymers were prepared and investigated for cellular imaging applications. First, a diazido derivative of SA was synthesized and subsequently PEGylated with polyethylene glycol monomethyl ether(mPEG) by metal-free azide-alkyne 1,3-dipolar cycloaddition reaction. The formed triazole group in niPEG-SA was then converted into cationic triazolium group by N-alkylation reaction. Botli the synthesized polymers, niPEG-SA and N-alkylated niPEG-SA, showed good dispersibility in water, but differences in self-assembly of nanostructures. The niPEG-SA with triazole groups self-assembled into micelles, while the N-alkylated mPEG-SA with triazolium groups sell-assembled into vesicles. Furthemiore, mPEG-SA and N-alkylated niPEG?SA naiioparticles showed bright fluorescence due to the aggregation of AIE-active SA molecules in the nanoparticles and could be successfully used as fluorescent naiioprobes for bioimaging applications in HeLa cancer cells. Finally, both the synthesized polymers showed minimal cytotoxicity and low hemolytic activity. Therefore, these PEGylated SA polymers proved to be promising bioimaging nanoprobes or traceable dnig delivery vehicles.
