A new two-step synthetic method was successfully developed to simplify the recrystallization process of lithium difluoro(oxalate)borate(LiODFB).Meanwhile,the purity of LiODFB as-prepared was determined by NMR,ICP-AES ...A new two-step synthetic method was successfully developed to simplify the recrystallization process of lithium difluoro(oxalate)borate(LiODFB).Meanwhile,the purity of LiODFB as-prepared was determined by NMR,ICP-AES and Karl Fisher measurements,respectively.The as-prepared LiODFB presents a high purity up to 99.95%.Its metal ions and water contents are under good control as well.Besides,its structure information and thermal properties were confirmed by FTIR,Raman and DSC-TGA analyses,respectively.LiODFB exerts fine thermostability and hypo-water-sensitivity and its structure information agrees well with previous literature.Furthermore,a combination of phase diagram and Raman spectroscopy were utilized to study the thermal phase behavior and ions coordination of LiODFB-DMC binary system to optimize the synthesis and recrystallization process.Although there are three types of molecular interaction forms(CIPs,AGG-IIa,AGG-IIIb)in LiODFB-DMC binary system,LiODFB can only be isolated as large single crystal solvate as LiODFB·(DMC)3/2 by slowly cooling subjected to the nucleation kinetics.Therefore,the fundamental information of our work is helpful in accelerating the application of LiODFB in Li-ion secondary batteries.展开更多
该研究旨在应用文献计量学,探索近十年中医药治疗阿尔茨海默病(AD)的国内外研究现状、热点和趋势。计算机检索Web of science、中国知网(CNKI),搜索2012年1月1日至2022年8月15日中医药治疗AD的相关文献,利用CiteSpace 6.1R2和VOSviewer ...该研究旨在应用文献计量学,探索近十年中医药治疗阿尔茨海默病(AD)的国内外研究现状、热点和趋势。计算机检索Web of science、中国知网(CNKI),搜索2012年1月1日至2022年8月15日中医药治疗AD的相关文献,利用CiteSpace 6.1R2和VOSviewer 1.6.15软件对作者、国家、机构、关键词、期刊等进行可视化分析。共纳入中文文献2254篇,英文文献545篇,年发文量总体呈波动上升趋势,发文量最多和中介中心性最大的国家均为中国,中、英文文献发文量最多的作者分别为孙国杰和WANG Qi,中、英文文献发文量最多的机构分别为湖北中医药大学和北京中医药大学,被引频次最高和中介中心性最高的英文期刊分别为《Journal of Ethnopharmacology》和《Neuroscience Letters》,中、英文文献的关键词分析显示中医药治疗AD研究主要集中在作用机制和治疗方法等方面,其中代谢组学、肠道菌群、氧化应激、tau蛋白过度磷酸化、β-淀粉样蛋白(Aβ)、炎症因子、自噬等为作用机制方面的研究重点,针刺、临床效果、肾虚痰瘀、通督启神等为临床研究方面的重点。该研究领域尚处于探索发展阶段,后续需加强各机构间有效的交流合作,开展更多中医药治疗AD的高质量基础研究,获得高级别循证医学证据,明确发病机制和方剂机制。展开更多
基金Project(51371198)supported by the National Natural Science Foundation of ChinaProject(K1202039-11)supported by the Science and Technology Project of Changsha,China
文摘A new two-step synthetic method was successfully developed to simplify the recrystallization process of lithium difluoro(oxalate)borate(LiODFB).Meanwhile,the purity of LiODFB as-prepared was determined by NMR,ICP-AES and Karl Fisher measurements,respectively.The as-prepared LiODFB presents a high purity up to 99.95%.Its metal ions and water contents are under good control as well.Besides,its structure information and thermal properties were confirmed by FTIR,Raman and DSC-TGA analyses,respectively.LiODFB exerts fine thermostability and hypo-water-sensitivity and its structure information agrees well with previous literature.Furthermore,a combination of phase diagram and Raman spectroscopy were utilized to study the thermal phase behavior and ions coordination of LiODFB-DMC binary system to optimize the synthesis and recrystallization process.Although there are three types of molecular interaction forms(CIPs,AGG-IIa,AGG-IIIb)in LiODFB-DMC binary system,LiODFB can only be isolated as large single crystal solvate as LiODFB·(DMC)3/2 by slowly cooling subjected to the nucleation kinetics.Therefore,the fundamental information of our work is helpful in accelerating the application of LiODFB in Li-ion secondary batteries.
文摘该研究旨在应用文献计量学,探索近十年中医药治疗阿尔茨海默病(AD)的国内外研究现状、热点和趋势。计算机检索Web of science、中国知网(CNKI),搜索2012年1月1日至2022年8月15日中医药治疗AD的相关文献,利用CiteSpace 6.1R2和VOSviewer 1.6.15软件对作者、国家、机构、关键词、期刊等进行可视化分析。共纳入中文文献2254篇,英文文献545篇,年发文量总体呈波动上升趋势,发文量最多和中介中心性最大的国家均为中国,中、英文文献发文量最多的作者分别为孙国杰和WANG Qi,中、英文文献发文量最多的机构分别为湖北中医药大学和北京中医药大学,被引频次最高和中介中心性最高的英文期刊分别为《Journal of Ethnopharmacology》和《Neuroscience Letters》,中、英文文献的关键词分析显示中医药治疗AD研究主要集中在作用机制和治疗方法等方面,其中代谢组学、肠道菌群、氧化应激、tau蛋白过度磷酸化、β-淀粉样蛋白(Aβ)、炎症因子、自噬等为作用机制方面的研究重点,针刺、临床效果、肾虚痰瘀、通督启神等为临床研究方面的重点。该研究领域尚处于探索发展阶段,后续需加强各机构间有效的交流合作,开展更多中医药治疗AD的高质量基础研究,获得高级别循证医学证据,明确发病机制和方剂机制。
