The effect of unilateral ureteral obstruction on the adrenal function in a rat model

【Objective】To explore the effect of unilateral ureteral obstruction on the adrenal function in a rat model.【Methods】36 SD rats were randomly divided into two groups:unilateral ureteral obstruction(UUO)model was employed,and sham-operated rats were used as control.28 days after surgery,all the rats were submitted to maximum exercise tolerance test(METT),and the maximum aerobic velocity was observed.At the day 0,day 28,and after METT,the serum levels of adrenaline,noradrenaline and corticosterone in rats were detected by ELISA.【Results】1 The maximum aerobic velocity in UUO model rats was lower than that in control rats(P<0.05).2 At the beginning(day 0),there no significant difference were found in the levels of adrenaline,noradrenaline and corticosterone between two groups.3 28 days after surgery,the levels of adrenaline,noradrenaline and corticosterone in UUO model rats were slightly higher than those in control rats,but the differences were not significant(P>0.05).4After METT,the levels of adrenaline and corticosterone in UUO model rats were lower than those in control rats significantly(P<0.05).The level of noradrenaline in UUO model rats was higher than that in control rats,but there is no significant difference between two groups(P>0.05).【Conclusions】Unilateral ureteral obstruction resulted in the decrease of exercise tolerance in rats,which may contribute to the inhibition of the adrenal secretion.