女性性功能障碍(female sexual dysfunction,FSD)是一种越来越受到重视的女性健康问题。随着社会进步和性医学的不断发展,FSD的治疗水平也不断提高。FSD的药物治疗分为激素类药物(如雌激素、鼻内睾酮、鼻内催产素等)和非激素类药物(如...女性性功能障碍(female sexual dysfunction,FSD)是一种越来越受到重视的女性健康问题。随着社会进步和性医学的不断发展,FSD的治疗水平也不断提高。FSD的药物治疗分为激素类药物(如雌激素、鼻内睾酮、鼻内催产素等)和非激素类药物(如氟班色林、奥培米芬、布雷默浪丹)。虽然一些药物已被FDA批准或正在进行临床试验,但医生和患者都需要客观了解目前治疗方法的局限性。本文旨在对当前FSD药物治疗方法进行综述。同时,由于FSD病因的多维性和复杂性,强调女性性功能障碍的治疗应遵循综合性的治疗原则,以改善女性性功能障碍。展开更多
目的:分析1990至2019年中国人群铬相关肺癌的疾病负担及其变化趋势,为制定卫生政策和疾病防控策略提供参考依据。方法:于2022年10月,利用全球疾病负担研究2019(Global Burden of Disease Study 2019,GBD 2019)公开的疾病、伤害和危险因...目的:分析1990至2019年中国人群铬相关肺癌的疾病负担及其变化趋势,为制定卫生政策和疾病防控策略提供参考依据。方法:于2022年10月,利用全球疾病负担研究2019(Global Burden of Disease Study 2019,GBD 2019)公开的疾病、伤害和危险因素负担情况的数据和研究结果,按照年份、性别等,分析1990至2019年中国人群职业性六价铬暴露导致的肺癌疾病负担及其变化情况。采用世界人口的平均年龄结构作为标准人口计算标化指标,进而与全球人群进行比较。结果:2019年中国人群铬相关肺癌的发病数、死亡数及伤残调整寿命年数(disability adjusted life years,DALY)分别为833例、790例、22 118人年,较1990年(257例、277例、8 631人年)分别增长224.1%、185.2%、156.3%,增幅均高于全球相应水平(101.0%、134.2%、117.2%);而2019年的标化发病率、死亡率及DALY率分别为0.059/10万、0.056/10万、1.555/10万,较1990年(0.022/10万、0.023/10万、0.729/10万)分别上升169.7%、137.4%、113.3%,平均年度变化百分比分别为18.8%、15.1%、13.5%,均高于全球水平(5.7%、8.4%、7.0%)。2019年中国人群因铬相关肺癌造成的DALY占中国人群所有原因疾病负担的0.005 8%(22 118/382 205 568),占全球人群铬相关肺癌DALY的51.8%(22 118/42 718)。2019年中国人群中男性铬相关肺癌发病数、死亡数及DALY数分别为576例(69.1%)、525例(66.5%)、14 717人年(66.5%),其疾病负担高于女性。结论:2019年中国人群铬相关肺癌导致的疾病负担占全因疾病负担的比例低,但占全球人群铬相关肺癌疾病负担的比例高,且1990至2019年标化发病率、死亡率、DALY率呈逐年上升趋势。展开更多
Multi-walled carbon nanotubes (CNTs) were grown on silicon nanoporous pillar array (Si-NPA) by thermal chemical vapor deposition method, and the structural and capacitive humidity sensing properties of CNT/Si-NPA were...Multi-walled carbon nanotubes (CNTs) were grown on silicon nanoporous pillar array (Si-NPA) by thermal chemical vapor deposition method, and the structural and capacitive humidity sensing properties of CNT/Si-NPA were studied. It was found that with the relative humidity (RH) changing from 11% to 95%, a device re-sponse of ~480% was achieved at the frequency of 50000 Hz, and a linear device response curve could be obtained by adopting longitudinal logarithmic coordinate. The response/recovery times were measured to be ~20 s and ~10 s, respectively, which indicated a rather fast response/recovery rate. The adsorption-desorption dynamic cycle experiments demonstrated the high measurement reproducibility of CNT/Si-NPA sensors. These excellent performances were attributed to the unique surface structure, morphology and chemical inertness of CNT/Si-NPA.展开更多
文摘女性性功能障碍(female sexual dysfunction,FSD)是一种越来越受到重视的女性健康问题。随着社会进步和性医学的不断发展,FSD的治疗水平也不断提高。FSD的药物治疗分为激素类药物(如雌激素、鼻内睾酮、鼻内催产素等)和非激素类药物(如氟班色林、奥培米芬、布雷默浪丹)。虽然一些药物已被FDA批准或正在进行临床试验,但医生和患者都需要客观了解目前治疗方法的局限性。本文旨在对当前FSD药物治疗方法进行综述。同时,由于FSD病因的多维性和复杂性,强调女性性功能障碍的治疗应遵循综合性的治疗原则,以改善女性性功能障碍。
基金Supported by the National Natural Science Foundation of China (Grant No. 10574112)
文摘Multi-walled carbon nanotubes (CNTs) were grown on silicon nanoporous pillar array (Si-NPA) by thermal chemical vapor deposition method, and the structural and capacitive humidity sensing properties of CNT/Si-NPA were studied. It was found that with the relative humidity (RH) changing from 11% to 95%, a device re-sponse of ~480% was achieved at the frequency of 50000 Hz, and a linear device response curve could be obtained by adopting longitudinal logarithmic coordinate. The response/recovery times were measured to be ~20 s and ~10 s, respectively, which indicated a rather fast response/recovery rate. The adsorption-desorption dynamic cycle experiments demonstrated the high measurement reproducibility of CNT/Si-NPA sensors. These excellent performances were attributed to the unique surface structure, morphology and chemical inertness of CNT/Si-NPA.
