南阳凹陷黑龙庙地区砂砾岩体规模小,多期砂体叠置,沉积期次划分难,非均质性强、甜点区难以预测。为此,利用可视化技术对三维地震资料进行精细构造解析与古构造恢复,研究砂砾岩体成因。在对5口井层序地层划分基础上,依据砂组-砂体的沉积...南阳凹陷黑龙庙地区砂砾岩体规模小,多期砂体叠置,沉积期次划分难,非均质性强、甜点区难以预测。为此,利用可视化技术对三维地震资料进行精细构造解析与古构造恢复,研究砂砾岩体成因。在对5口井层序地层划分基础上,依据砂组-砂体的沉积旋回性与地震反射结构,划分砂砾岩体沉积期次;通过岩石物理分析与正演模拟明确砂砾岩体地球物理响应特征。通过井点处扇根、扇中、扇端地震反射特征与相同层位其他点处的地震反射特征进行相关分析,确定扇根、扇中、扇端的平面分布;实测砂砾岩体岩性、物性参数与波阻抗属性,交汇分析确定有效区分砂砾岩与泥岩的波阻抗属性的值域。依据高精度反演得到的波阻抗数据体,在砂砾岩体储层波阻抗值域及顶底反射层位控制下,求出有效储层厚度与分布,圈定砂砾岩体储层甜点区的范围。以此为依据在其甜点区上部署的HL1井日产油5.46 m 3,预测结果与实钻井一致。展开更多
目的探讨联合血栓弹力图(thromboelastography,TEG)、凝血指标和血小板参数评估慢性静脉功能不全(chronic venous insufficiency,CVI)患者血栓形成风险的预测价值。方法回顾性纳入本院2020年11月至2022年3月共计CVI患者359名,根据是否...目的探讨联合血栓弹力图(thromboelastography,TEG)、凝血指标和血小板参数评估慢性静脉功能不全(chronic venous insufficiency,CVI)患者血栓形成风险的预测价值。方法回顾性纳入本院2020年11月至2022年3月共计CVI患者359名,根据是否发生静脉血栓栓塞症(venous thromboembolism,VTE)分为VTE组和非VTE组。分析2组的基线特征,以及联合血栓弹力图、凝血指标和血小板参数对CVI患者发生VTE的风险预测价值。采用单因素Logistic回归分析的方筛选风险因子,采用多因素Logistic回归构建预测模型,通过曲线下面积(AUC)、灵敏度、特异度等指标以及临床决策曲线(DCA)进行模型性能评价。结果对照组相比,血栓形成组R值降低(3.27±0.71 vs 3.87±1.16,P<0.05);凝血酶原时间(PT)降低(11.08±3.02 vs 12.86±3.48,P<0.001),纤维蛋白原(Fib)增高(3.46 vs 3.10,P<0.05),D二聚体(DD)增高(3.00 vs 1.12,P<0.001);血小板分布宽度(PDW)降低(12.01±3.87 vs 13.98±3.20,P<0.001)。以PT、DD、R值、Fib和PDW作为预测因子建立的血栓形成预测模型ROC曲线下面积为0.8422,灵敏度和特异度分别为36.78%和95.59%。临床决策曲线(DCA)判断当模型预测值为0.1~0.7时可使患者获益。结论联合TEG、凝血指标和血小板参数预测CVI患者发生VTE风险具有一定的效果。展开更多
Objective This study aimed to investigate the lipid-lowering activity of LFBEP-C1 in high glucose-fed Caenorhabditis elegans(C.elegans).Methods In this study,the fermented barley protein LFBEP-C1 was prepared and test...Objective This study aimed to investigate the lipid-lowering activity of LFBEP-C1 in high glucose-fed Caenorhabditis elegans(C.elegans).Methods In this study,the fermented barley protein LFBEP-C1 was prepared and tested for its potential anti-obesity effects on C.elegans.The worms were fed Escherichia coli OP50(E.coli OP50),glucose,and different concentrations of LFBEP-C1.Body size,lifespan,movement,triglyceride content,and gene expression were analyzed.The results were analyzed using ANOVA and Tukey's multiple comparison test.Results Compared with the model group,the head-swing frequency of C.elegans in the group of LFBEP-C1 at 20μg/mL increased by 33.88%,and the body-bending frequency increased by 27.09%.This indicated that LFBEP-C1 improved the locomotive ability of C.elegans.The average lifespan of C.elegans reached 13.55 days,and the body length and width of the C.elegans decreased after LFBEP-C1 intake.Additionally,LFBEP-C1 reduced the content of lipid accumulation and triglyceride levels.The expression levels of sbp-1,daf-2,and mdt-15 significantly decreased,while those of daf-16,tph-1,mod-1,and ser-4 significantly increased after LFBEP-C1 intake.Changes in these genes explain the signaling pathways that regulate lipid metabolism.Conclusion LFBEP-C1 significantly reduced lipid deposition in C.elegans fed a high-glucose diet and alleviated the adverse effects of a high-glucose diet on the development,lifespan,and exercise behavior of C.elegans.In addition,LFBEP-C1 regulated lipid metabolism mainly by mediating the expression of genes in the sterol regulatory element-binding protein,insulin,and 5-hydroxytryptamine signaling pathways.展开更多
Bitter melon(Momordica Charania L.),a member of the Cucurbitaceae family,is widely distributed across tropical and subtropical regions.Saponin,an important functional component of bitter melon,has been proven to exert...Bitter melon(Momordica Charania L.),a member of the Cucurbitaceae family,is widely distributed across tropical and subtropical regions.Saponin,an important functional component of bitter melon,has been proven to exert hypoglycemic effects similarly to insulin,and also possesses lipid-lowering properties inhibiting preadipocyte differentiation and fat synthesis^([1]).展开更多
文摘南阳凹陷黑龙庙地区砂砾岩体规模小,多期砂体叠置,沉积期次划分难,非均质性强、甜点区难以预测。为此,利用可视化技术对三维地震资料进行精细构造解析与古构造恢复,研究砂砾岩体成因。在对5口井层序地层划分基础上,依据砂组-砂体的沉积旋回性与地震反射结构,划分砂砾岩体沉积期次;通过岩石物理分析与正演模拟明确砂砾岩体地球物理响应特征。通过井点处扇根、扇中、扇端地震反射特征与相同层位其他点处的地震反射特征进行相关分析,确定扇根、扇中、扇端的平面分布;实测砂砾岩体岩性、物性参数与波阻抗属性,交汇分析确定有效区分砂砾岩与泥岩的波阻抗属性的值域。依据高精度反演得到的波阻抗数据体,在砂砾岩体储层波阻抗值域及顶底反射层位控制下,求出有效储层厚度与分布,圈定砂砾岩体储层甜点区的范围。以此为依据在其甜点区上部署的HL1井日产油5.46 m 3,预测结果与实钻井一致。
文摘目的探讨联合血栓弹力图(thromboelastography,TEG)、凝血指标和血小板参数评估慢性静脉功能不全(chronic venous insufficiency,CVI)患者血栓形成风险的预测价值。方法回顾性纳入本院2020年11月至2022年3月共计CVI患者359名,根据是否发生静脉血栓栓塞症(venous thromboembolism,VTE)分为VTE组和非VTE组。分析2组的基线特征,以及联合血栓弹力图、凝血指标和血小板参数对CVI患者发生VTE的风险预测价值。采用单因素Logistic回归分析的方筛选风险因子,采用多因素Logistic回归构建预测模型,通过曲线下面积(AUC)、灵敏度、特异度等指标以及临床决策曲线(DCA)进行模型性能评价。结果对照组相比,血栓形成组R值降低(3.27±0.71 vs 3.87±1.16,P<0.05);凝血酶原时间(PT)降低(11.08±3.02 vs 12.86±3.48,P<0.001),纤维蛋白原(Fib)增高(3.46 vs 3.10,P<0.05),D二聚体(DD)增高(3.00 vs 1.12,P<0.001);血小板分布宽度(PDW)降低(12.01±3.87 vs 13.98±3.20,P<0.001)。以PT、DD、R值、Fib和PDW作为预测因子建立的血栓形成预测模型ROC曲线下面积为0.8422,灵敏度和特异度分别为36.78%和95.59%。临床决策曲线(DCA)判断当模型预测值为0.1~0.7时可使患者获益。结论联合TEG、凝血指标和血小板参数预测CVI患者发生VTE风险具有一定的效果。
基金supported by the priority academic program development of Jiangsu Higher education institutionsthe National Natural Science Foundation of China [31801538, 32072200]China Postdoctoral Science Foundation[2019M651747].
文摘Objective This study aimed to investigate the lipid-lowering activity of LFBEP-C1 in high glucose-fed Caenorhabditis elegans(C.elegans).Methods In this study,the fermented barley protein LFBEP-C1 was prepared and tested for its potential anti-obesity effects on C.elegans.The worms were fed Escherichia coli OP50(E.coli OP50),glucose,and different concentrations of LFBEP-C1.Body size,lifespan,movement,triglyceride content,and gene expression were analyzed.The results were analyzed using ANOVA and Tukey's multiple comparison test.Results Compared with the model group,the head-swing frequency of C.elegans in the group of LFBEP-C1 at 20μg/mL increased by 33.88%,and the body-bending frequency increased by 27.09%.This indicated that LFBEP-C1 improved the locomotive ability of C.elegans.The average lifespan of C.elegans reached 13.55 days,and the body length and width of the C.elegans decreased after LFBEP-C1 intake.Additionally,LFBEP-C1 reduced the content of lipid accumulation and triglyceride levels.The expression levels of sbp-1,daf-2,and mdt-15 significantly decreased,while those of daf-16,tph-1,mod-1,and ser-4 significantly increased after LFBEP-C1 intake.Changes in these genes explain the signaling pathways that regulate lipid metabolism.Conclusion LFBEP-C1 significantly reduced lipid deposition in C.elegans fed a high-glucose diet and alleviated the adverse effects of a high-glucose diet on the development,lifespan,and exercise behavior of C.elegans.In addition,LFBEP-C1 regulated lipid metabolism mainly by mediating the expression of genes in the sterol regulatory element-binding protein,insulin,and 5-hydroxytryptamine signaling pathways.
基金supported by the National Natural Science Foundation of China[32202050]the National Natural Science Foundation of China[32101965]+2 种基金China Postdoctoral Science Foundation[2020M671373]Jiangsu Postdoctoral Research Funding Program[2020Z070]Innovation Training Program for College Students[202310299649X]。
文摘Bitter melon(Momordica Charania L.),a member of the Cucurbitaceae family,is widely distributed across tropical and subtropical regions.Saponin,an important functional component of bitter melon,has been proven to exert hypoglycemic effects similarly to insulin,and also possesses lipid-lowering properties inhibiting preadipocyte differentiation and fat synthesis^([1]).
