针刺对慢性自发性荨麻疹患者应急使用抗组胺药的影响:基于随机对照试验结果的二次分析

目的:本研究通过对前期多中心随机对照试验数据进行二次分析,评估针刺作为非药物疗法在减少慢性自发性荨麻疹(Chronic Spontaneous Urticaria,CSU)患者对应急使用抗组胺药依赖方面的潜力,为CSU的多元化管理提供新的证据。方法:患者随机分配到针刺组、假针刺组和等待治疗组,并记录了4周治疗期及4周随访期内应急使用抗组胺药的情况。本研究主要评估指标为应急使用抗组胺药的平均天数,通过单因素方差分析(ANOVA)及Tukey HSD多重比较探讨不同时期组间应急使用抗组胺药的平均天数差异。对于组内比较,采用Welch的t检验评估不同时期的差异。非参数Mann-Whitney-U检验进一步验证了组间差异的稳健性。卡方检验和Fisher精确检验用于分析治疗组间用药人数的统计学差异。结果:共分析了296名患者的数据。与针刺组相比,等待治疗组在治疗期(0.30,95%CI0.08 to 0.53,P=0.005)和随访期(0.31,95%CI0.12 to 0.50,P<0.001)应急使用抗组胺药的频率增加。组内分析表明,尽管3组应急使用抗组胺药的平均天数有所下降,但这些变化无统计学意义(P>0.05)。此外,与等待治疗组相比,治疗和随访期间接受针刺治疗的患者中应急用药的人数较少(P<0.05)。结论:针刺治疗显示了减轻CSU患者依赖应急用药的潜力,为减少药物负担提供了一个有效的非药物治疗选择。

不同月龄豚鼠自发膝骨关节炎过程中全膝关节的病理变化

背景:豚鼠因具有与人类相似的膝关节结构和接近的组织病理学特征,被认为是最有助于评估人类原发性骨关节炎的自发模型。目的:通过对1-18月龄豚鼠的全膝关节组织病理学分析,探讨豚鼠自发膝骨关节炎的病理过程。方法:选取健康1,6,10,14,16,18月龄Hartley雌性豚鼠各8只,将股四头肌进行苏木精-伊红染色,整体膝关节进行苏木精-伊红染色和甲苯胺蓝染色,在光镜下观察软骨、软骨下骨、滑膜、半月板、肌肉的组织病理学情况,进行关节软骨Mankin评分和滑膜炎评分,并进行二者的相关性分析。结果与结论:(1)随着豚鼠月龄的增长,关节软骨Mankin评分越高(P<0.05),滑膜炎病理评分也逐渐增高(P<0.05),且二者之间存在显著正相关(r=0.641,P<0.001);(2)18月龄豚鼠软骨下骨骨髓病变发病率达50%,半月板损伤发生率达37.5%;且出现不同程度的骨赘和关节间隙变窄等病变,仅有少数豚鼠出现股四头肌肉炎症;(3)结果说明豚鼠随着年龄增长,出现明显的软骨缺损、滑膜炎症、软骨下骨病变、半月板损伤、骨赘形成和关节间隙变窄等,均与人类原发性膝骨关节炎的病理过程相似,是理想的自发性膝骨关节炎模型。

基于肠道微生态探讨针灸“从肠治皮”干预慢性荨麻疹的机制研究

慢性荨麻疹(Chronic urticaria,CU)是一种涉及自身免疫及变态反应的常见皮肤病,给患者和社会带来了沉重负担。中医“肺合大肠,大肠者,皮其应”理论早已表明肠腑功能与皮部存在紧密的生理病理联系,随着现代医学理论“肠-皮轴”的提出,肠道微生态与CU相关性也逐渐成为研究的热点,纠正肠道微生态失调将是临床治疗CU的新趋势。针灸具有良性调节肠道微生态的效应作用,且临床治疗CU疗效肯定。因此,本文将近年来肠道微生态与CU之间的研究进展加以总结,探讨针灸通过调节肠道微生态治疗CU的可行性,围绕“从肠治皮”的角度为针灸治疗CU的机制研究提供新思路。

针灸治疗慢性荨麻疹研究概况

通过查阅近10年来针灸治疗慢性荨麻疹临床研究相关文献,了解针灸治疗慢性荨麻疹的临床研究进展,归纳总结针灸治疗慢性荨麻疹的常用治疗方法,结果发现2种方法联合应用最为常见;在单纯疗法中针刺、艾灸、自血疗法被临床广泛应用。

Impacts of a wind stress and a buoyancy flux on the seasonal variation of mixing layer depth in the South China Sea

The seasonal variation of mixing layer depth （MLD） in the ocean is determined by a wind stress and a buoy- ance flux. A South China Sea （SCS） ocean data assimilation system is used to analyze the seasonal cycle of its MLD. It is found that the variability of MLD in the SCS is shallow in summer and deep in winter, as is the case in general. Owing to local atmosphere forcing and ocean dynamics, the seasonal variability shows a regional characteristic in the SCS. In the northern SCS, the MLD is shallow in summer and deep in winter, affected coherently by the wind stress and the buoyance flux. The variation of MLD in the west is close to that in the central SCS, influenced by the advection of strong western boundary currents. The eastern SCS presents an annual cycle, which is deep in summer and shallow in winter, primarily impacted by a heat flux on the air-sea interface. So regional characteristic needs to be cared in the analysis about the MLD of SCS.

成都地铁1号线三期区间隧道勘察浅层天然气测试及影响评价研究

成都地铁1号线三期缓丘区区间隧道受到苏码头气田逸出的浅层天然气影响。采用钻孔现场测试,辅以室内气相色谱分析的方法,测试天然气浓度、成分;并结合隧道所处构造部位、洞身以上是否形成气囊等因素进行综合评价。根据测试结果,判定该隧道为低瓦斯隧道,隧道施工验证了评价结果的正确性。

Efficacy of electroacupuncture stimulating Zusanli(ST36)and Xuanzhong(GB39)on synovial angiogenesis in rats with adjuvant arthritis

OBJECTIVE:To investigate the efficacy of electroacupuncture(EA)stimulating Zusanli(ST36)and Xuanzhong(GB39)on synovial angiogenesis in rats with adjuvant arthritis(AA).METHODS:AA models were established by bilateral injection of Freund's complete adjuvant(FCA)in male Sprague-Dawley rats.Three days after injection,rats were given EA at Zusanli(ST36)and Xuanzhong(GB39)acupoints,once every other day,for 16 d.The arthritis index score,paw volume,and hematoxylin-eosin(HE)staining was performed for each animal.Angiogenesis marker cluster of differentiation 34(CD34)expression and synovial cell apoptosis in synovial tissue were observed.The levels of Notch1,hairy and enhancer of split homolog-1(Hes1),transforming growth factor-beta(TGF-β)and basic fibroblast growth factor(bFGF)were subsequently detected.RESULTS:We found that EA significantly decreased arthritis index scores,paw volume,and HE staining scores.EA could significantly inhibit the expression of CD34,promoting apoptosis of synovial cells in the joint synovial tissue of AA rats.The expression of Notch1 signaling pathway proteins and mR NAs(Notch1,Hes1,TGF-β,and bFGF)were markedly downregulated by EA treatment.CONCLUSIONS:These results prove that EA attenuates synovial angiogenesis by inhibiting the Notch1 signaling pathway in AA rat models.Based on our findings,we propose that EA is a promising complementary and alternative therapy in rheumatoid arthritis.

慢性荨麻疹相关基因研究进展

慢性荨麻疹(chronic urticarial,CU)是当今社会严重影响人类生活质量的常见病,其发病机制复杂,影响因素广泛。近年来,CU的基因研究逐渐成为热点,相关研究试图从基因水平上探讨CU的发生机制,并取得了一些成果。本文对最近五年有关CU基因的研究进行综述,以期更详尽地了解CU相关致病基因的研究进展。

元结作品辑佚、编年与考辨

元结是盛、中唐之际古文运动的先驱人物,著名的文学家、思想家,其人、其文受到了杜甫、欧阳修、黄庭坚等人的极力推崇。元结在世时,曾多次自编文集,晚唐时出现全本。此后,元结作品以刻本、抄本、影印本等多种形式流传,有关元结作品的整理、校注与评价也逐步展开。

Progress of regional oceanography study associated with western boundary current in the South China Sea

Recent progress of physical oceanography in the South China Sea (SCS) associated with the western boundary current (WBC) and eddies is reviewed in this paper. It includes Argo observations of the WBC, eddy detection in the WBC based on satellite images, cross-continental shelf exchange in the WBC, eddy-current interaction, interannual variability of the WBC, air-sea interaction, the SCS throughflow (SCSTF), among others. The WBC in the SCS is strong, and its structure, variability and dynamic processes on seasonal and interannual time scales are yet to be fully understood. In this paper, we summarize progresses on the variability of the WBC, eddy-current interaction, air-sea interaction, and the SCSTF achieved in the past few years. Firstly, using the drifting buoy observations, we point out that the WBC becomes stronger and narrower after it reaches the central Vietnam coast. The possible mechanisms influencing the ocean circulation in the northern SCS are discussed, and the dynamic mechanisms that induce the countercurrent in the region of northern branch of WBC in winter are also studied quantitatively using momentum balance. The geostropic component of the WBC was diagnosed using the ship observation along 18°N, and we found that the WBC changed significantly on interannual time scale. Secondly, using the ship observations, two anti-cyclonic eddies in the winter of 2003/2004 in the northern SCS, and three anti-cyclonic eddies in the summer of 2007 along 18°N were studied. The results show that the two anti-cyclonic eddies can propagate southwestward along the continental shelf at the speed of first Rossby wave (～0.1 ms-1 ) in winter, and the interaction between the three anti-cyclonic eddies in summer and the WBC in the SCS is preliminarily revealed. Eddies on the continental shelf of northern SCS propagated southeastward with a maximum speed of 0.09 ms-1 , and those to the east of Vietnam coast had the largest kinetic energy, both of which imply strong interaction between eddy activity and WBC in the SCS. Thirdly, strong intraseasonal variability (ISV) of sea surface temperature (SST) near the WBC regions was found, and the ISV signal of SST in winter weakens the ISV signal of latent heat flux by 20%. Fourthly, the long-term change of SCSTF volume transport and its connection with the ocean circulation in the Pacific were discussed.

The assimilation experimentin the southwestern South China Sea in summer 2000

We performed an assimilation experiment of the southern South China Sea in summer 2000, and the altimeter data were assimilated into Princeton Ocean Model (POM). The result was evaluated with the in situ data. There were obvious improvements of the currents in the southern South China Sea, and the modeling uncertainty coming from the error of wind stress forcing was reduced. This experiment provides us a new idea about improving the modeling of the ocean currents.

慢性荨麻疹常用疗效评价量表的最小临床效应值研究概述

国内对荨麻疹疗效评价量表的最小临床重要差值(minimal clinically important difference, MCID)以及最小重要差值(minimal important difference, MID)的研究仍有空缺,需要进一步挖掘探索。通过收集整理国内外慢性荨麻疹MID和MCID的研究,研究人员可以在日后中医药临床试验将MID和MCID作为治疗慢性荨麻疹的疗效评价的重要参考指标。

Preliminary results of a new global ocean reanalysis

Using a new global ocean reanalysis of the second generation Global Ocean Data Assimilation System of the Beijing Climate Center(BCC_GODAS2.0) spanning the period 1990-2009,we firstly quantify the accuracy of BCC_GODAS2.0 in representing the temperature and salinity by comparing with OISST and SODA data.The results show that the assimilation system may effectively improve the estimations of temperature and salinity by assimilating all kinds of observations,especially in the equatorial eastern Pacific.Moreover,the root mean square errors of monthly temperature and salinity are respectively reduced by 0.53℃ and 0.28 psu,compared with the model control simulation results.Then,the applicability of this ocean reanalysis for sea surface temperature(SST) anomaly variability in the tropical Pacific is evaluated with the observational HadISST data.The NINO3 index of the new reanalysis shows a good agreement with that of HadISST,with a correlation of 93.6%.Variations in SST from BCC_GODAS2.0 are similar to those obtained from HadISST data along the equator,showing the major large zonal-scale features such as the strong magnitude of seasonal cycle.The amplitude of SST anomaly standard deviation in the equatorial eastern Pacific is also closer to observations(HadISST) than NCEP GODAS does.Besides,the first two leading empirical orthogonal function(EOF) modes of the monthly SST anomalies over the tropical Pacific region are explored.The EOF1 pattern of BCC_GODAS2.0 captures a traditional El Ni o pattern,which improves magnitudes of the positive SST anomaly in the cold tongue of the eastern Pacific.The EOF2 pattern exhibits a El Ni o Modoki pattern.Comparatively,the EOF2 pattern of BCC_GODAS2.0 extends more strongly toward the subtropics.It also overcomes the problem that negative loadings are confined in the narrow equatorial eastern Pacific.Consequently,the magnitude and spatial distribution of the leading EOF patterns of BCC_GODAS2.0 are well consistent with those of HadISST.