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塞利尼索在非多发性骨髓瘤血液肿瘤中的应用及研究进展
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作者 肖植文 齐凌 李菲 《中国实验血液学杂志》 CAS CSCD 北大核心 2024年第4期1295-1299,共5页
核输出蛋白1(XPO1)是数百种蛋白质的主要转运蛋白。塞利尼索是第一代XPO1抑制剂,目前在多发性骨髓瘤的治疗中获得了较多的关注,同时最新临床试验也证实,无论是单药还是联合其他化疗方案,塞利尼索在白血病、淋巴瘤中同样能取得较好的治... 核输出蛋白1(XPO1)是数百种蛋白质的主要转运蛋白。塞利尼索是第一代XPO1抑制剂,目前在多发性骨髓瘤的治疗中获得了较多的关注,同时最新临床试验也证实,无论是单药还是联合其他化疗方案,塞利尼索在白血病、淋巴瘤中同样能取得较好的治疗效果。本文总结了塞利尼索治疗非多发性骨髓瘤血液肿瘤的临床前研究和临床试验结果,旨在探讨未来如何选择塞利尼索单药或联合其他方案进行诱导化疗。 展开更多
关键词 塞利尼索 白血病 非霍奇金淋巴瘤 骨髓增生异常综合征 骨髓增殖性肿瘤
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磷钼酸铵/聚丙烯酸复合凝胶吸附剂的合成及对铯的分离 被引量:4
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作者 胡佩卓 刘莲 +3 位作者 王海静 肖智文 南矞 钱丽娟 《核化学与放射化学》 CAS CSCD 北大核心 2019年第4期361-369,I0002,共10页
以丙烯酸为基底合成了磷钼酸铵/聚丙烯酸复合吸附剂(AMP-PA)。采用红外光谱(FTIR)、X射线衍射(XRD)等方法对AMP-PA进行表征。研究了振荡时间、酸度、Cs+浓度对铯吸附的影响,及多种离子存在下吸附剂对铯离子的选择性吸附。静态实验结果表... 以丙烯酸为基底合成了磷钼酸铵/聚丙烯酸复合吸附剂(AMP-PA)。采用红外光谱(FTIR)、X射线衍射(XRD)等方法对AMP-PA进行表征。研究了振荡时间、酸度、Cs+浓度对铯吸附的影响,及多种离子存在下吸附剂对铯离子的选择性吸附。静态实验结果表明:AMP-PA吸附铯大约5 h达到平衡;HNO3浓度在0~3.0 mol/L范围内对铯的吸附量影响不大,吸附过程符合Langmuir方程,计算得到的最大吸附量达到4.7 mg/g;采用3.0 mol/L NH4Cl+1.0 mol/L HNO3解吸,解吸率大约为70%;多种离子存在下对铯离子具有选择性吸附。动态柱实验发现,AMP-PA对铯的吸附量为4.32 mg/g,解吸率约为50.4%。在高浓度杂质离子Na^+、K^+、Sr^2+、Co^2+、Fe^3+、Zn^2+、Ca^2+存在下,AMP-PA柱可以选择性分离铯,在铯的淋洗液中Co^2+低于检测限,含量最高的Fe3+分离因子为3,浓度比起始浓度降低四个数量级。 展开更多
关键词 磷钼酸铵 聚丙烯酸 吸附
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虚实结合的电磁频谱监测训练系统设计 被引量:11
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作者 肖志文 常明 《电子设计工程》 2020年第3期106-110,共5页
针对电磁频谱监测装备模拟训练问题,提出基于虚拟与现实相结合的网络化电磁频谱监测训练系统实现方法,并完成了系统设计。采用全数字中频接收机工作原理设计了频谱扫描接收单元,实现了真实环境电磁信号的有效接收;采用HFSS仿真优化设计... 针对电磁频谱监测装备模拟训练问题,提出基于虚拟与现实相结合的网络化电磁频谱监测训练系统实现方法,并完成了系统设计。采用全数字中频接收机工作原理设计了频谱扫描接收单元,实现了真实环境电磁信号的有效接收;采用HFSS仿真优化设计了两种监测天线,可以满足超短波和微波常用频段的电磁信号接收;针对数据采集效率问题,提出多线程并行处理有效提高扫描速率的方法;采用虚拟仿真实现电磁信号测向训练功能。系统以真实环境电磁信号为监测对象开展训练,以较低成本提高了装备操作训练的真实感、高效性,为装备教学提供了一种有效的手段。 展开更多
关键词 电磁频谱 虚拟仿真 装备操作训练 监测
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Combined Subtemporal-Supralabyrinthine Approach to Geniculate Ganglion for Management of Facial Paralysis in Temporal Bone Fracture 被引量:2
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作者 JIANG Li-xin xiao zhi-wen +3 位作者 MA Yu-kun TU Bo LONG Zhen LIAO Zhi-fang 《Journal of Otology》 2012年第1期31-35,共5页
Objective To investigate the clinical outcomes of facial never decompression via a combined subtemporal-su- pralabyrinthine approach to geniculate ganglion for management of facial paralysis in temporal bone fracture.... Objective To investigate the clinical outcomes of facial never decompression via a combined subtemporal-su- pralabyrinthine approach to geniculate ganglion for management of facial paralysis in temporal bone fracture. Methods Eighteen patients with unilateral facial paresis due to temporal bone fracture were treated between March 2003 and March 2011. Facial function was House-Braekmann(HB) grade m in 6 patients, HB grade V in 9 patients and HB grade VI in 3 patients. The preoperative mean air conduction threshold was 52 dB HL for the 15 cases with longitudinal temporal bone fracture and showed severe sensorineural heating loss in the 3 cases with transverse temporal bone fracture. Fracture lines were detected in 15 cases on temporal bone axial CT scans and ossicular disruption was determined in 11 cases by virtual CT endoscopy. The geniculate ganglion or the tympanic mastoid segment of the facial nerve showed an irregular morphology on curved planar reformation images of the facial nerve canal. After an intact canal wall mastoi- do-epitympanectomy, the ossicular chain recess was opened by drilling through the was disrupted, the incus was removed to damage was evaluated. If the ossicular chain was intact, the supralabyrinthine cells between the tegmen tympani and ossicular chain. If the ossicular chain access the supralabyrinthine recess. The geniculate ganglion and the distal labyrinthine segment of the facial nerve were exposed. After completing facial nerve decompression, the dislocated incus was replaced, or a fractured incus was reshaped to bridge the space between the malleus and the stapes. Results Pronounced ganglion geniculatum swelling was found in 15 cases of longitudinal temporal bone fracture, with greater petrosus nerves damage in 3 cases and bleeding in 5 cases. Disrupted ossicular chains were seen in 11 cases, including dislocated incus resulting in crushing of the horizontal portion of the facial nerve in 3 cases and fracture of the incus long process in 1 case. In 3 cases of transverse fractures, dehiscence on the promontory, semicircular canal or oval window was found. All cases had primary healing with no complication. At follow-ups ranging from 0.5 to 3 years (average 1.2 years), facial nerve function recovered to HB grade I in 11 cases, 11 in 5 cases and m in 2 cases. Overall hearing recovery was 33 dB. Conclusion The clinical outcomes concerning facial nerve function and hearing recovery are satisfactory via a combined subtemporal-supralabyrinthine approach to the geniculate ganglion for facial nerve decompression in temporal bone fracture patients with facial paralysis. 展开更多
关键词 Temporal bone fracture Facial paralysis Facial nerve decompression Ear surgery
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