浇注过程中铝液泄漏的数值模拟

建立模拟铸造过程中铝液泄漏的模型以预防爆炸,包括瞬态溜槽流动,孔口出流和扩散。将仿真数据和理论计算结果进行比较,验证该模型的适应性和准确性。即使改变混合炉中铝液高度和出口半径,铝液在浇注过程也不会发生泄漏。溜槽中的铝液以波浪状的形式向前移动并引起泄漏,泄漏铝液在地面上的扩散呈长条状,铝液泄漏量和扩散面积随着混合炉中铝液高度的增大而增大。

Effects of Trajectory Wind Direction on Ion Concentration of PM_(10)

Objective To study the characterization apportionment of main ion concentrations of PM10 under the influence of trajectory wind direction in London. Methods PM10 samples from 1 May 1995 to 30 October 1995 of Oxford Street of Central London were collected, the metals and anions of which were measured using atomic absorption spectrometry （AAS） and ion chromatography （IC）. Composite trajectories representative of the air mass arriving in London at the same period were calculated based on basic routine back trajectories from the British Atmospheric Data Centre （BADC）. Results Concentration apportionments of main ions were similar when the trajectory was plotted back at 6 h, 12 h, and 24 h, some were obviously different. Mg, Ba, Pb, and Cu had similar peak apportionments at the area 180°-320°, but Zn and Ni at the area of 90°-270°, NO3^- and SO4^2- at the area of 100°-220°. Cl^- concentration peak apportionment was at the area of 220°-300°, which showed that Cl^- mainly came from the North Sea. Conclusion Trajectory wind direction has important effect on ion concentration apportionment of PM10 in London. The ions have similar concentration peak apportionments or their correlation coefficients are statistically significant.

Simultaneous expression of two pathogenic genes in four Chinese patients affected with inherited retinal dystrophy

●AIM:To describe the complex,overlapping phenotype of four Chinese patients with inherited retinal dystrophies(IRDs)who harbored two pathogenic genes simultaneously.●METHODS:This retrospective study included 4 patients affected with IRDs.Medical and ophthalmic histories were obtained,and clinical examinations were performed.A specific Hereditary Eye Disease Enrichment Panel(HEDEP)based on exome capture technology was used for genetic screening.●RESULTS:Four patients were identified to harbor disease-causing variants in two different genes.Patient retinitis pigmentosa(RP)01-II:1 exhibited both classical ABCA4-induced Stargardt disease(STGD)1 and USH2 Aassociated RP,patient RP02-III:2 exhibited both classical ABCA4-induced STGD1 and CDH23-associated RP,patient RP03-II:1 exhibited both USH2 A-induced autosomal recessive retinitis pigmentosa(arRP)syndrome and SNRNP200-induced autosomal dominant retinitis pigmentosa(adRP),and patient RP04-II:2 exhibited USH2 Ainduced arRP syndrome and EYS-induced arRP at the same time.●CONCLUSION:Our study demonstrates that genotype–phenotype correlations and comprehensive genetic screening is crucial for diagnosing IRDs and helping family planning for patients suffering from the disease.

Room-temperature ionic conductivity of Ba,Y,Al co-doped Li_(7)La_(3)Zr_(2)O_(12)solid electrolyte after sintering

The Ba,Y and A1 co-doped Li_(7)La_(3)Zr_(2)O_(12)(LLZO)was prepared by the solid-state reaction method.Effect of sintering on the crystallographic structure,morphology,total conductivity,relative density and contractibility rate of the prepared solid electrolyte was studied,respectively.The sintered samples were characterized by X-ray diffractometer(XRD),scanning electron microscopy(SEM),electrochemical impedance spectra(EIS)and inductively coupled plasma atomic emission spectrometry(ICP-AES)techniques,respectively.The cubic garnet phase Ba,Y and Al co-doped LLZO is obtained,and the room-temperature total conductivity of the Ba,Y and Al co-doped LLZO solid electrolyte is improved significantly by eliminating the grain boundary resistances and improving the densifications with controlling sintering temperature(T)and time(t),respectively.Sintering at 1160-1190℃for 12 h and at 1190℃for6-15 h,respectively,the Ba,Y and Al co-doped LLZO solid electrolytes are cubic garnet phase.Sintering at1180-1190℃for 12 h and at 1190℃for 12-18 h,respectively,SEM images of the cross section of the Ba,Y and Al co-doped LLZO solid electrolytes exhibit the distinctively flattened morphology without any noticeable grain boundaries.The total conductivity,relative density and contractibility rate of Li_(6.52)La_(2.98)-Ba_(0.02)Zr_(1.9)Y_(0.1)Al_(0.2)O_(12)solid electrolyte are 2.96×10^(-4) S·cm^(-1),94.19%and 18.61%,respectively.

Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice

Intracytoplasmic sperm injection (ICSI) is commonly used to solve male infertility problems. Previous studies showed that early environmental exposure of an embryo may influence postnatal development. To detect whether ICSI operations affect the reproductive health of a male or his offspring, we established assisted reproductive technologies (ART) conceived mouse models, and analyzed gene expression profiles in the testes of both ICSI and naturally conceived (NC) newborn F1 mice using micro-array analysis. Among the differentially expressed genes, we focused on the expression of eight male reproduction-related genes. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) was used to analyze the expression of these genes in the testes of both adult and old F1 generation mice and adult F2 generation mice. Our results showed that down-regulated and somatic cell-expressed genes in newborn mice retained their differential expression patterns in adult and old F1 generation individuals, implying the persistence and fetal origin of the alteration in the expression of these genes. The intergenerational transmission of differential gene expression was observed, but most changes tended to be reduced in adult F2 generations. Controlled ovarian hyperstimulation (COH) and in vitro fertilization (IVF) mice models were added to explore the precise factors contributing to the differences in ICSI offspring. The data demonstrated that superovulation, in vitro culture, and mechanical stimulation involved in ICSI had a cumulative effect on the differential expression of these male reproductive genes.