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An overview of the policies and models of integrated development for solar and wind power generation in China
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作者 LiWei Yang xiaoqing gao ZhenChao Li 《Research in Cold and Arid Regions》 CSCD 2023年第3期122-131,共10页
Under the goal of “Carbon Emission Peak and Carbon Neutralization”, the integrated development between various industries and renewable energy(photovoltaic, wind power) is of great significance in China. This paper ... Under the goal of “Carbon Emission Peak and Carbon Neutralization”, the integrated development between various industries and renewable energy(photovoltaic, wind power) is of great significance in China. This paper summarizes the relevant policies, integration schemes and typical cases of the integrated development between renewable energy and other industries. First, the development status of wind and solar generation in China is introduced. Second, we summarize the relevant policies issued by the National Development and Reform Commission, National Energy Administration and other departments to promote the integrated development in photovoltaic and wind power generation in China. Third, eight kinds of photovoltaic three-dimensional development models are described, including “photovoltaic + agriculture, industry, environmental protection, transportation, architecture, communication, hydrogen and ecology”. Fourth, eight kinds of wind power threedimensional development models are summarized, including “Offshore wind power + marine ranch, marine energy, marine tourism, marine oil and gas, hydrogen, communication, Energy Island” and “Onshore wind power+ courtyard”. In the future, the promotion and application of the above integrated development projects will be accelerated. This overview aims to provide reference for the design in photovoltaic and wind energy systems and help potential investors to make decisions. 展开更多
关键词 Renewable energy Solar PV Wind power POLICIES Integrated development
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Transfection of the glial cell line-derived neurotrophic factor gene promotes neuronal differentiation 被引量:7
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作者 Jie Du xiaoqing gao +3 位作者 Li Deng Nengbin Chang Huailin Xiong Yu Zheng 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第1期33-40,共8页
Glial cell line-derived neurotrophic factor recombinant adenovirus vector-transfected bone marrow mesenchymal stem cells were induced to differentiate into neuron-like cells using inductive medium containing retinoic ... Glial cell line-derived neurotrophic factor recombinant adenovirus vector-transfected bone marrow mesenchymal stem cells were induced to differentiate into neuron-like cells using inductive medium containing retinoic acid and epidermal growth factor. Cell viability, micro- tubule-associated protein 2-positive cell ratio, and the expression levels of glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein-43 protein in the su- pernatant were significantly higher in glial cell line-derived neurotrophic factor/bone marrow mesenchymal stem cells compared with empty virus plasmid-transfected bone marrow mes- enchymal stem cells. Furthermore, microtubule-associated protein 2, glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein743 mRNA levels in cell pellets were statistically higher in glial cell line-derived neurotrophic factor/bone marrow mesen- chymal stem cells compared with empty virus plasmid-transfected bone marrow mesenchymal stem cells. These results suggest that glial cell line-derived neurotrophic factor/bone marrow mesenchymal stem cells have a higher rate of induction into neuron-like cells, and this enhanced differentiation into neuron-like cells may be associated with up-regulated expression of glial cell line-derived neurotrophic factor, nerve growth factor and growth-associated protein-43. 展开更多
关键词 nerve regeneration bone marrow mesenchymal stem cells cell differentiation neu-ron-like cells glial cell line-derived neurotrophic factor recombinant adenovirus vector TRANSFECTION retinoic acid epidermal growth factor nerve growth factor growth-associated protein-43 neuralregeneration
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Do neural precursor cells exist in a distal neurogenic region following cerebral hemorrhage? 被引量:2
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作者 Chaoxian Yang Ling Zhou +1 位作者 Li Deng xiaoqing gao 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第5期325-330,共6页
BACKGROUND: Cerebral injury in adult mammals can induce neural precursor cells (NPCs) to proliferate and migrate towards the focal zone, but it is unclear whether endogenous NPCs can migrate towards regions distal ... BACKGROUND: Cerebral injury in adult mammals can induce neural precursor cells (NPCs) to proliferate and migrate towards the focal zone, but it is unclear whether endogenous NPCs can migrate towards regions distal to the hemorrhagic focus or whether NPCs differentiate in the peripheral hemorrhagic region. OBJECTIVE: To investigate the distribution of endogenous NPCs in different brain regions of rats with experimental cerebral hemorrhage, as well as NPC proliferation and differentiation with time. DESIGN, TIME AND SE'B'ING: A randomized, controlled animal experiment was performed at the Department of Neurobiology, Luzhou Medical College, between January 2007 and October 2008. MATERIALS: Bromodeoxyuridine (BrdU) was purchased from Roche, Germany. Mouse anti-rat BrdU monoclonal antibody, rabbit anti-nestin polyclonal antibody, rabbit anti-neuron specific enolase (NSE) polyclonal antibody were purchased from Wuhan Boster, China. Rabbit anti-glial fibrillary acidic protein (GFAP) polyclonal antibody was purchased from Sigma, USA. METHODS: Thirty-five adult Sprague Dawley rats were randomly divided into three groups: (1) cerebral hemorrhage group (n = 25), rats were stereotaxically administered 50 p L autologous arterial blood via the dorsal caudate putamen to induce cerebral hemorrhage; (2) sham-surgery group (n = 5), rats underwent surgery but did not receive blood injection; (3) blank control group (n = 5), rats received no surgery and blood administration. At 2 hours after surgery, all rats were intraperitoneally administered BrdU. MAIN OUTCOME MEASURES: Distribution and proliferation of BrdU-positive cells were observed by immunohistochemical staining. BrdU-positive cell differentiation into neurons and glial cells in the peripheral hemorrhagic region was detected by double-label immunofluorescence. RESULTS: Immunohistochemistry results revealed that BrdU-positive cells existed not only in the peripheral hemorrhagic region, such as the subependymal layer and hippocampal dentate gyrus, but also in the lateral septal nucleus, diagonal band, habenular nucleus, and cerebral cortex. Following cerebral hemorrhage, BrdU-positive cells in the peripheral hemorrhagic region gradually increased (P 〈 0.05), and peaked at 7 14 days. Double-label immunofluorescence showed that with time after cerebral hemorrhage, BrdU/nestin-positive cells decreased, but BrdU/GFAP- and BrdU/NSE-positive cells increased in the peripheral cerebral hemorrhagic region (P 〈 0.05). CONCLUSION: Cerebral hemorrhage can induce the proliferation of endogenous NPCs, which peaks at 1-2 weeks after hemorrhage. NPCs can also migrate towards the regions distal to the hemorrhagic focus, such as a diagonal band or lateral septal nucleus. NPCs can gradually differentiate with increasing time after hemorrhage. 展开更多
关键词 rats cerebral hemorrhage neural precursor cells DIFFERENTIATION distal neuroyenic region distal neurogenic region
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Abundant Lump Solutions and Interaction Phenomena to the Kadomtsev-Petviashvili-Benjamin-Bona-Mahony Equation 被引量:1
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作者 Jianqing Lü Sudao Bilige +2 位作者 xiaoqing gao Yuexing Bai Runfa Zhang 《Journal of Applied Mathematics and Physics》 2018年第8期1733-1747,共15页
In this paper, we obtained a kind of lump solutions of the Kadomtsev-Petviashvili-Benjamin-Bona-Mahony (KP-BBM) equation with the assistance of Mathematica. Some contour plots with different determinant values are seq... In this paper, we obtained a kind of lump solutions of the Kadomtsev-Petviashvili-Benjamin-Bona-Mahony (KP-BBM) equation with the assistance of Mathematica. Some contour plots with different determinant values are sequentially made to show that the corresponding lump solutions tend to zero when x2+y2→∞. Particularly, lump solutions with specific values of the include parameters are plotted, as illustrative examples. Finally, a combination of stripe soliton and lump soliton is discussed to the KP-BBM equation, in which such a solution presents two different interesting phenomena: lump-kink and lump-soliton. Simultaneously, breather rational soliton solutions are displayed. 展开更多
关键词 Lump Solution KP-BBM Equation HIROTA Bilinear Form INTERACTION Phenomenon BREATHER Soliton
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Heavy Metals Contamination in Greenhouse Soils and Vegetables in Guanzhong, China 被引量:2
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作者 Ling Liu Jinyin Lu +3 位作者 Zhenwen Zhang Hai Zheng xiaoqing gao Wei Zhang 《Journal of Encapsulation and Adsorption Sciences》 2014年第3期80-88,共9页
This study used a flame atomic absorption spectrometer (FAAS) and atomic fluorescence spec-trophotometer (AFS) to detect the concentrations of chromium (Cr), cadmium (Cd), lead (Pb), hy-drargyrum (Hg) and arsenic (As)... This study used a flame atomic absorption spectrometer (FAAS) and atomic fluorescence spec-trophotometer (AFS) to detect the concentrations of chromium (Cr), cadmium (Cd), lead (Pb), hy-drargyrum (Hg) and arsenic (As) in soils and three genotypes of vegetables in greenhouse, as well as analyzed the physical and chemical properties of soils, including soil pH, soil organic matter (OM), basic nutrients, electrical conductivity (EC) and cation exchange capacity (CEC) in Guan- zhong areas, Shaanxi province, China. The results showed that comparing to subsoil, the sampled topsoil is enriched in Cr, Cd, Pb, As and Hg. Cd (0.83 - 3.17 mg·kg-1) and Hg (0.40 - 1.44 mg·kg-1) are exceeding the limited value stated in “the 2006 Greenhouse Vegetable Producing Environmental Quality Evaluation Standards” of 0.40 mg·kg-1 and 0.35 mg·kg-1 respectively. However, Nanzhuang greenhouse soil is within the limits. The heavy metal pollution index (HPI) of soil in Sanyuan (8.10) is the highest and in Dongzhang (4.23) is the lowest. The contents of Pb (0.201 - 0.376 mg·kg-1) were exceeding the limited value (0.20 mg·kg-1) in vegetables species, and Cd (0.0363 - 0.0572 mg·kg-1) in some place were also exceeding the limited value (0.05 mg·kg-1). Greenhouse soils were becoming acidified year after year;the ratios of N, P and K in soil were seriously imbalanced. According to the impacting factors, OM, pH, available P, EC and CEC have obviously effected the accumulation of Cr and Hg. However, there was not enough evidence for the effects of available nitrogen and available potassium. 展开更多
关键词 HEAVY Metals SOILS VEGETABLES GREENHOUSE
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Comparative study of surface energy and land-surface parameters in different climate zones in Northwest China
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作者 JiaXi Yang ZhenChao Li +4 位作者 Ye Yu ZhiYuan Zheng XuHong Hou xiaoqing gao 《Research in Cold and Arid Regions》 CSCD 2019年第4期283-294,共12页
Based on observational data of arid,semi-arid and semi-humid areas in Northwest China,the characteristics of surface-wa ter heat transfer and land-surface parameters were compared and analyzed.The results show that th... Based on observational data of arid,semi-arid and semi-humid areas in Northwest China,the characteristics of surface-wa ter heat transfer and land-surface parameters were compared and analyzed.The results show that the annual mean net radi ation was largest in the semi-humid area,followed by the semi-arid area,and then the arid area:77.72 W/m^2,67.73 W/m^2,and 55.47 W/m^2,respectively.The annual mean sensible heat flux was largest in the arid area,followed by the semi-arid and semi-humid areas,while latent heat flux showed the reverse.The annual mean sensible heat flux in arid,semi-arid,and semi-humid areas was 85.7 W/m^2,37.59 W/m^2,and 27.55 W/m^2,respectively.The annual mean latent heat flux was 0 W/m^2,26.08 W/m^2,and 51.19 W/m2,respectively.The annual mean soil-heat flux at the 5-cm soil layer in arid,semi-arid,and semi-humid areas was 1.00 W/m^2,0.82 W/m^2,and 1.25 W/m^2,respectively.The annual mean surface albedo was larg est in the arid area,followed by the semi-humid area;and the smallest was in the semi-arid area:0.24,0.21,and 0.18,re spectively.The annual mean Bowen ratio in the semi-arid area was about 2.06,and that in semi-humid area was about 0.03.The annual mean soil thermal conductivity in the arid,semi-arid,and semi-humid areas was 0.26 W/(m k),1.15 W/(m k),and 1.20 W/(m k),respectively. 展开更多
关键词 surface energy LAND-SURFACE PARAMETERS DIFFERENT climate ZONES NORTHWEST China
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Variation characteristics and prediction of pollutant concentration during winter in Lanzhou New District, China
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作者 DongYu Jia XiaoXia Li +1 位作者 xiaoqing gao LiWei Yang 《Research in Cold and Arid Regions》 CSCD 2020年第5期317-328,共12页
PM2.5 and PM10 were the main air pollutants during winter in Lanzhou New District,China.In this paper,WRF model output combined with hourly monitoring data of pollutant concentration was used to analyze characteristic... PM2.5 and PM10 were the main air pollutants during winter in Lanzhou New District,China.In this paper,WRF model output combined with hourly monitoring data of pollutant concentration was used to analyze characteristics of the concentration change and to study the relationship between meteorological elements and PM10/PM2.5 in Lanzhou New District in January,2018.Meanwhile,the concentration changes of PM2.5 and PM10 were predicted by wavelet analysis combined with BP neural network.The results show that:(1)Due to the cold front process in winter,PM2.5 was negatively correlated with the water vapor mixing rate.PM10 was positively correlated with air temperature and negatively correlated with air pressure.(2)There was an inversion layer in the atmosphere near the high value day of PM2.5 and PM10,the surface was controlled by low pressure,low wind speed,and the situation of low value day of PM2.5 was the opposite.On the day of high value of PM10,the air temperature below 600 hPa was higher,and the wind speed near the surface was also higher.(3)Wavelet analysis combined with BP(Back Propagation)neural network had a good prediction effect on PM2.5,which could basically reflect the hourly change of PM2.5 concentration.However,the simulation effect of PM10 was poor,and the input parameters of surrounding pollutants should be added to improve the prediction effect. 展开更多
关键词 PM2.5 PM10 WRF Wavelet neural network Lanzhou New District
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Spatial and temporal patterns of solar radiation in China from 1957 to 2016
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作者 PeiDu Li xiaoqing gao +2 位作者 JunXia Jiang LiWei Yang YuJie Li 《Research in Cold and Arid Regions》 CSCD 2022年第1期68-78,共11页
Solar energy is clean and renewable energy that plays an important role in mitigating impacts of environmental problems and climate change.Solar radiation received on the earth's surface determines the efficiency ... Solar energy is clean and renewable energy that plays an important role in mitigating impacts of environmental problems and climate change.Solar radiation received on the earth's surface determines the efficiency of power generation and the location and layout of photovoltaic arrays.In this paper,the average daily solar radiation of 77 stations in China from 1957 to 2016 was analyzed in terms of spatial and temporal characteristics.The results indicate that Xinjiang,the Qinghai-Tibet Plateau,North,Central and East China show a decreasing trend with an average of 2.54×10^(−3)MJ/(m^(2)⋅10a),while Northwest and Northeast China are basically stabilized,and Southwest China shows a clear increasing trend with an average increase of 1.79×10^(−3)MJ/(m^(2)⋅10a).The average daily solar radiation in summer and winter in China from 1957 to 2016 was 18.74 MJ/m^(2)and 9.09 MJ/m^(2),respectively.Except for spring in Northwest,East and South China,and summer in northeast China,the average daily solar radiation in all other regions show a downward trend.A critical point for the change is 1983 in the average daily solar radiation.Meanwhile,large-scale(25−30 years)oscillation changes are more obvious,while small-scale(5−10 years)changes are stable and have a global scope.The average daily solar radiation shows an increasing-decreasing gradient from west to east,which can be divided into three areas west of 80°E,80°E−100°E and east of 100°E.The average daily solar radiation was 2.07 MJ/m^(2)in the 1980s,and that in 1990s lower than that in the 1960s and the 1970s.The average daily solar radiation has rebounded in the 21st century,but overall it is still lower than the average daily solar radiation from 1957 to 2016(13.87 MJ/m^(2)). 展开更多
关键词 average daily solar radiation temporal variability spatial distribution characteristics China
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Application of the Generalized Simplest Equation Method to the Burgers Equation
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作者 Yuexing Bai Sudao Bilige +1 位作者 xiaoqing gao Jianqing Lü 《Journal of Applied Mathematics and Physics》 2017年第1期101-109,共9页
We successfully constructed wide classes of exact solutions for the Burgers equation by using the generalized simplest equation method. This method yielded a B&aumlcklund transformation between the Burgers equatio... We successfully constructed wide classes of exact solutions for the Burgers equation by using the generalized simplest equation method. This method yielded a B&aumlcklund transformation between the Burgers equation and a related constraint equation. By dealing with the constraint equation, we obtained the traveling wave solutions and non-traveling wave solutions of the Burgers equation. 展开更多
关键词 The GENERALIZED Simplest EQUATION Method EXACT Solution the BURGERS EQUATION
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Study on the atmospheric heat engine efficiency and heat source characteristics of the Qinghai-Tibet Plateau in summer
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作者 Yujie LI xiaoqing gao +5 位作者 Yaoming MA Zeyong HU Zhenchao LI Liwei YANG Xiao JIN Xiyin ZHOU 《Science China Earth Sciences》 SCIE EI CAS CSCD 2024年第1期117-133,共17页
There are many types of atmospheric heat engines in land-air systems.The accurate definition,calculation and interpretation of the efficiency of atmospheric heat engines are key to understanding energy transfer and tr... There are many types of atmospheric heat engines in land-air systems.The accurate definition,calculation and interpretation of the efficiency of atmospheric heat engines are key to understanding energy transfer and transformation of landair systems.The atmosphere over the Qinghai-Tibet Plateau(QTP)in summer can be regarded as a positive heat engine.The study of the heat engine efficiency is helpful to better understand land-air interaction and thermal-dynamic processes on the QTP.It also provides a new perspective to explain the impact of the QTP on the climate of China,East Asia and even the world.In this paper,we used MOD08 and ERA5 reanalysis data to calculate the atmospheric heat engine efficiency,surface heat source and atmospheric heat source on the QTP in summer(May to September)from 2000 to 2020.The average atmospheric heat engine efficiency on the QTP in summer from 2000 to 2020 varies between 1.2%and 1.5%,which is less than 1.6%;the heat engine efficiency in summer is higher than that in June,July and August;the Qaidam Basin is the region with the highest atmospheric heat engine efficiency,followed by the western QTP.The mean surface heat source on the QTP in summer from 2000 to 2020 is 96.0 W m^(−2),the atmospheric heat source is 90.7 W m^(−2),and the release of precipitation condensation latent heat is the most important component of the atmospheric heat source on the QTP in summer.There is a strong and significant positive correlation between the atmospheric heat engine efficiency and the surface heat source on the QTP in summer.The precipitation condensation latent heat is the most important component of the atmospheric heat source in summer and can reflect the precipitation process.There is a strong and significant negative correlation between the atmospheric heat engine efficiency and the atmospheric heat source on the QTP in summer. 展开更多
关键词 Qinghai-Tibet Plateau Climate change Land-air system Atmospheric heat engine Heat source on the Qinghai-Tibet Plateau
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Optical manipulation of ratio-designable Janus microspheres
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作者 YULU CHEN CONG ZHAI +4 位作者 xiaoqing gao HAN WANG ZUZENG LIN XIAOWEI ZHOU CHUNGUANG HU 《Photonics Research》 SCIE EI CAS CSCD 2024年第6期1239-1249,共11页
Angular optical trapping based on Janus microspheres has been proven to be a novel method to achieve controllable rotation.In contrast to natural birefringent crystals,Janus microspheres are chemically synthesized of ... Angular optical trapping based on Janus microspheres has been proven to be a novel method to achieve controllable rotation.In contrast to natural birefringent crystals,Janus microspheres are chemically synthesized of two compositions with different refractive indices.Thus,their structures can be artificially regulated,which brings excellent potential for fine and multi-degree-of-freedom manipulation in the optical field.However,it is a considerable challenge to model the interaction of heterogeneous particles with the optical field,and there has also been no experimental study on the optical manipulation of microspheres with such designable refractive index distributions.How the specific structure affects the kinematic properties of Janus microspheres remains unknown.Here,we report systematic research on the optical trapping and rotating of various ratio-designable Janus microspheres.We employ an efficient T-matrix method to rapidly calculate the optical force and torque on Janus microspheres to obtain their trapped postures and rotational characteristics in the optical field.We have developed a robust microfluidic-based scheme to prepare Janus microspheres.Our experimental results demonstrate that within a specific ratio range,the rotation radii of microspheres vary linearly and the orientations of microsphere are always aligned with the light polarization direction.This is of great importance in guiding the design of Janus microspheres.And their orientations flip at a particular ratio,all consistent with the simulations.Our work provides a reliable theoretical analysis and experimental strategy for studying the interaction of heterogeneous particles with the optical field and further expands the diverse manipulation capabilities of optical tweezers. 展开更多
关键词 POLARIZATION RATIO refractive
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Recent Progress of Circularly Polarized Luminescence Materials from Chinese Perspectives 被引量:3
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作者 Xuefeng Yang xiaoqing gao +5 位作者 You-Xuan Zheng Hua Kuang Chuan-Feng Chen Minghua Liu Pengfei Duan Zhiyong Tang 《CCS Chemistry》 CSCD 2023年第12期2760-2789,共30页
The research on circularly polarized luminescence(CPL)has garnered significant attention in recent years due to its many potential applications.One aspect of this research involves the pursuit of chiral materials that... The research on circularly polarized luminescence(CPL)has garnered significant attention in recent years due to its many potential applications.One aspect of this research involves the pursuit of chiral materials that posess both high luminescence efficiency and dissymmetry factors.The investigation of CPL behavior is of paramount importance because the structural information of chiral luminescent systems in the excited state can be uncovered.The objective of this review is to offer a comprehensive overview of the latest advancements in the CPL research field,with a particular focus on the development of chiral emissive materials,including organic,inorganic,and hybrid substances.Furthermore,this review outlines the recent applications of these materials in areas such as displays,photoelectric devices,anticounterfeiting measures,and sensors.Finally,we highlight the primary challenges and potential prospects of CPL materials.Our aspiration is that this endeavor will contribute new perspectives and insights that further advancements in related research fields. 展开更多
关键词 circularly polarized luminescence circularly polarized electroluminescence circular dichroism optoelectronic materials excited-state chirality CHIRALITY
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Ultra-stable silica-coated chiral Au-nanorod assemblies: Core-shell nanostructures with enhanced chiroptical properties 被引量:3
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作者 Bing Han Lin Shi +4 位作者 xiaoqing gao Jun Guo Ke Hou Yonglong Zheng Zhiyong Tang 《Nano Research》 SCIE EI CAS CSCD 2016年第2期451-457,共7页
Chiral nano-assemblies with amplified optical activity have attracted particular interest for their potential application in photonics, sensing and catalysis. Yet it still remains a great challenge to realize their re... Chiral nano-assemblies with amplified optical activity have attracted particular interest for their potential application in photonics, sensing and catalysis. Yet it still remains a great challenge to realize their real applications because of the instability of these assembled nanostructures. Herein, we demonstrate a facile and efficient method to fabricate ultra-stable chiral nanostructures with strong chiroptical properties. In these novel chiral nanostructures, side-by-side assembly of chiral cysteine-modified gold nanorods serves as the core while mesoporous silica acts as the shell. The chiral core-shell nanostructures exhibit an evident plasmonic circular dichroism (CD) response originating from the chiral core. Impressively, such plasmonic CD signals can be easily manipulated by changing the number as well as the aspect ratio of Au nanorods in the assemblies located at the core. In addition, because of the stabilization effect of silica shells, the chiroptical performance of these core-shell nanostructures is significantly improved in different chemical environments. 展开更多
关键词 chiral core-shell nanostructure plasmonic circular dichroism gold nanorods SELF-ASSEMBLY high stability
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Electromagnetic field-enhanced chiral dimanganese trioxide nanoparticles mitigate Parkinson’s disease
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作者 Xiuxiu Wang Jing Zhao +8 位作者 Weiwei Wang Meiru Lu Aihua Qu Maozhong Sun xiaoqing gao Chen Chen Hua Kuang Chuanlai Xu Liguang Xu 《Science China Chemistry》 SCIE EI CAS CSCD 2022年第10期1911-1920,共10页
The misfolding and aggregation ofα-synuclein(α-syn)is closely associated with Parkinson’s disease(PD).Here,chiral dimanganese trioxide(Mn_(2)O_(3))nanoparticles(NPs)were prepared for PD treatment enhanced by a noni... The misfolding and aggregation ofα-synuclein(α-syn)is closely associated with Parkinson’s disease(PD).Here,chiral dimanganese trioxide(Mn_(2)O_(3))nanoparticles(NPs)were prepared for PD treatment enhanced by a noninvasive electromagnetic field(MF).The affinity constants of D-NPs towardα-syn monomer(mono)orα-syn fibril were 3.5 times or 5.2 times higher,respectively,than those of L-NPs,and the mechanical force generated by NPs under a MF further promoted the interaction between NPs andα-syn to amplify the difference between L-NPs and D-NPs.As the synergy effect of the preferentially affinity ability and MF-induced mechanical forces,D-NPs exhibited a better inhibitory efficiency onα-syn fibrillization than L-NPs.Furthermore,after differentially cellular uptake of L-/D-NPs via the caveolin-mediated pathway,as reactive oxygen species(ROS)-scavengers,D-NPs possess higher efficiency in decreasing intracellular ROS level than L-NPs to provide higher cytoprotective efficiency to neuron cells.In vivo data showed that after treatment with D-NPs under a MF for 60 days,α-syn concentration in the cerebrospinal fluid of PD mice decreased 81%,while dopamine level in the brain of PD mice increased 2.3-fold.These findings indicated the potential of utilizing the synergic interplay of chiral NPs and MF for treating disease and opened a new path to explore the nanoscale chirality for regulating the biological effect. 展开更多
关键词 electromagnetic field CHIRAL dimanganese trioxide NANOPARTICLES mitigate Parkinson’s Disease
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Stability of selenium and its speciation analysis in water using automatic system separation and HR-ICP-MS measurement
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作者 Junqiang Yang Yawen Chen +10 位作者 Keliang Shi Kesheng Hu Run Li xiaoqing gao Qian Wang Weibo Zhang Yun Zhou Yanyun Wang Jiangang He Tonghuan Liu Xiaolin Hou 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第7期3444-3450,共7页
A simple and convenient method has been developed for the pre-concentration and separation of inorganic selenium species from environmental water samples using anion exchange chromatographic column combined with high ... A simple and convenient method has been developed for the pre-concentration and separation of inorganic selenium species from environmental water samples using anion exchange chromatographic column combined with high resolution inductively coupled plasma mass spectrometry(HR-ICP-MS)measurement.^(75)Se(Ⅳ) and ^(75)Se(Ⅵ)were prepared and used as tracers during the experiments.The volatility of selenium during solution evaporation was investigated to establish a reliable water samples pretreatment procedure.The parameters which affect the uptake of Se(Ⅳ)and Se(Ⅵ)on Dowex1×8 resin was optimized and the procedure for Se(Ⅳ)and Se(Ⅵ)separation was proposed.Both Se(Ⅳ)and Se(Ⅵ)are retained on the column in natural or alkaline solution with high distribution coefficient.The successive gradient elution of pre-concentrated species of selenium with HNO_(3)solution allows to differentiate between them.Se(Ⅳ)and Se(Ⅵ)finally were eluted with 0.05 mol/L HNO_(3) and 5.0 mol/L HNO_(3),respectively.The proposed method has been successfully verified using the certified reference materials(CRMs)of real water samples,and spiked recoveries for real samples were 98%-104%with 5%relative standard deviations(RSDs).The developed procedure is proved to be reliable and can be used for the rapid determination of selenium species in environmental water samples. 展开更多
关键词 Inorganic selenium SPECIATION Automatic system separation Rapid determination Water sample
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