Identification of Pulmonary Hypertension Animal Models Using a New Evolutionary Machine Learning Framework Based on Blood Routine Indicators

Pulmonary Hypertension(PH)is a global health problem that affects about 1%of the global population.Animal models of PH play a vital role in unraveling the pathophysiological mechanisms of the disease.The present study proposes a Kernel Extreme Learning Machine(KELM)model based on an improved Whale Optimization Algorithm(WOA)for predicting PH mouse models.The experimental results showed that the selected blood indicators,including Haemoglobin(HGB),Hematocrit(HCT),Mean,Platelet Volume(MPV),Platelet distribution width(PDW),and Platelet–Large Cell Ratio(P-LCR),were essential for identifying PH mouse models using the feature selection method proposed in this paper.Remarkably,the method achieved 100.0%accuracy and 100.0%specificity in classification,demonstrating that our method has great potential to be used for evaluating and identifying mouse PH models.

High-performance distributed feedback quantum dot lasers with laterally coupled dielectric gratings

The combination of grating-based frequency-selective optical feedback mechanisms,such as distributed feedback(DFB)or distributed Bragg reflector(DBR)structures,with quantum dot(QD)gain materials is a main approach towards ultrahigh-performance semiconductor lasers for many key novel applications,as either stand-alone sources or on-chip sources in photonic integrated circuits.However,the fabrication of conventional buried Bragg grating structures on GaAs,GaAs/Si,GaSb,and other material platforms has been met with major material regrowth difficulties.We report a novel and universal approach of introducing laterally coupled dielectric Bragg gratings to semiconductor lasers that allows highly controllable,reliable,and strong coupling between the grating and the optical mode.We implement such a grating structure in a low-loss amorphous silicon material alongside GaAs lasers with InAs/GaAs QD gain layers.The resulting DFB laser arrays emit at pre-designed 0.8 THz local area network wavelength division multiplexing frequency intervals in the 1300 nm band with record performance parameters,including sidemode suppression ratios as high as 52.7 dB,continuous-wave output power of 26.6 mW(room temperature)and 6 mW(at 55℃),and ultralow relative intensity noise(RIN)of<-165 dB/Hz(2.5-20 GHz).The devices are also capable of isolator-free operating under very high external reflection levels of up to-12.3 dB while maintaining high spectral purity and ultralow RIN qualities.These results validate the novel laterally coupled dielectric grating as a technologically superior and potentially cost-effective approach for fabricating DFB and DBR lasers free of their semiconductor material constraints,which are thus universally applicable across different material platforms and wavelength bands.

Construction of a Noncentrosymmetric Luminescent Coordination Polymer from [BaL3] Unit (L = Pyridine-2,6-dicarboxylate Acid) and Li(l) Ion

Summary of main observation and conclusion This work presents the synthesis, crystal structure and properties of a novel noncentrosymmetric (NCS) coordination polymer (CP), namely,(Me2NH2)3[BaLi(2,6-PyDC)3(H2O)](1)(2,6-PyDC = pyridine-2,6-dicarboxylate acid), which represents the first example of BaLi-CPs with 2,6-PyDC ligand. Single-crystal X-ray structural analysis reveals that the compound features a two-dimensional (2D) layered structure. The simplified structure of each layer belongs to the hcb topology. The second harmonic generation (SHG) response of 1 is about 0.5 times that of KH2PO4 (KDP) marker. What is more, 1 emits bright blue light upon the excitation of 365 nm UV light with the quantum yield (QX Ф) of 1.63%. The successful con struction of this compound convinces the feasibility of constructing NCS CPs via the combi nation of [BaL3] unit and Li(l) ion.

A Comparative Study on the Luminescence of the Cd2＋ and Mn2＋ Coordination Polymers Based on the Same Mixed Ligands

Presented here is the solvothermal preparation of two luminescent coordination polymers （L-CPs） based on the same mixed ligands, namely [Cd2（1,4-NDC）2（dppe）] （1） and [Mn3（OH）2（1,4-NDC）2（dppe）（H2O）] （2） （1,4-NDCH2 = 1,4-naphthalene dicarboxylic acid, dppe---- 1,3-di（4-pyridyl）propane）. Both the title compounds feature a neutral three-dimensional （3D） network. Photoluminescence （PL） studies indicated that the compound 1 based on d10 Cd2＋ exhibited dual emissions with tunable intensities that could result in direct white-light emission based on the in- traligand charge transfer （LLCT）; while the compound 2 showed a single band of yellow emission based on the charge transfer between the ligands and the metal ion （LMCT）, due to the partially filled d-orbital of Mn2＋ ion. The temperature-dependent powder X-ray diffraction patterns （PXRD） and PL spectra were further measured to identify their thermal stabilities. This work may provide a certain guiding significance for exploiting L-CPs based on different metal ions.

Noncentrosymmetric K_(2)Mn_(3)(SO_(4))_(3)F_(2)·4H_(2)O and Rb_(2)Mn_(3)(SO_(4))_(3)F_(2)·2H_(2)O with pseudo-KTP structures

Two fluoride sulfates,K_(2)Mn_(3)(SO_(4))_(3)F_(2)·4H_(2)O(Ⅰ) and Rb_(2)Mn_(3)(SO_(4))_(3)F_(2)·2H_(2)O (Ⅱ) are obtained by water solution method.Single-crystal X-ray diffraction analysis indicated that they crystallize in space groups of Cmc2_(1.)Their structures feature a pseudo-KTP structure consisting of interconnecting[Mn_(3)(SO_(4))3F_(2)(H_(2)O)2]_(∞) layers,which are further packing along the a axis with alkali metal cations balancing the charges.The structure relationships between the two compounds are discussed.Secondharmonic generation measurements manifest that Ⅰ and Ⅱ have similar second-harmonic generation responses of about 0.2 and 0.25 times that of KH_(2)PO_(4).