The synthesis problem of a 6-SPS Stewart platform with semi-regular hexagons is studied in this paper. We present a genetic algorithm approach to synthesize a Stewart platform whose workspace must include a desired wo...The synthesis problem of a 6-SPS Stewart platform with semi-regular hexagons is studied in this paper. We present a genetic algorithm approach to synthesize a Stewart platform whose workspace must include a desired workspace with orienting capabilities in a given 3D region. Based on the observation that the constant orientation workspace gets smaller as the given orientations increase, a simple method is presented to describe the workspace with orienting capabilities, which need only search the constant orientation workspaces with the eight sets of extremal orientations of given 3D region and use their common part.To verify the method, a numerical example is given. The GA is used to optimize architectural parameters and obtain a compact manipulator. The method is applied to synthesize a Stewart platform whose workspace must include a prescribed cylinder with orienting capabilities.展开更多
Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of l...Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of life in PADAM patients. Methods： Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function （IIEF） scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen （PSA）, etc., and the data before treatment were compared with those after treatment in the same group. Results： After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85±0.36 before treatment and 5.02±0.83 after treatmnet （P〈0.05）; luteinizing hormone of 7.33±2.14 and 4.84±1.43 （P〈0.01）, follicule-stimulating hormone of 10.22±4.48 and 6.47±3.28 （P〈0.01）, respectively. The level of PSA failed to change significantly （1.94±0.55 and 2.06±0.47, P〉0.05）. Conclusion： JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.展开更多
When the resultant of applied forces does not pass through the center of an active landmass, the landmass will rotate, giving rise to a rotational tectonic stress field. The motion of a fault along the principal stres...When the resultant of applied forces does not pass through the center of an active landmass, the landmass will rotate, giving rise to a rotational tectonic stress field. The motion of a fault along the principal stress plane is de-termined by the mechanic features of the plane. Tensile fractures occur on the faults in the direction of the principal extensional stress plane, and fault-depression basins will be formed under a long-term action. Thrusting and over-thrusting occur on faults in the direction of the principal compressional stress plane, or folds may be formed as a result. Information on geology shows that the North China landmass, which remained stable and intact for a long time, became disjointed in the Eogene period. In the course of disjunction, anticlockwise rotation took place in the Shanxi-Hebei-Shaanxi (Jin-Ji-Shan) landmass, giving rise to the fault-depression system in its periphery. In the Pliocene epoch the landmass lost stability and its eastern boundary moved westward. As a result, the Shanxi gra-ben system appeared and Ordos landmass was formed. Structural and mechanic features of the main faults around Jin-Ji-Shan landmass can be explained with principal stress plane of a rotational tectonic stress field.展开更多
Based on the latest displacement of Huoshan piedmont fault, Mianshan west-side fault and Taigu fault obtained from the beginning of 1990s up to the present, the characteristics of distribution and displacement of surf...Based on the latest displacement of Huoshan piedmont fault, Mianshan west-side fault and Taigu fault obtained from the beginning of 1990s up to the present, the characteristics of distribution and displacement of surface rup-ture zone of the 1303 Hongtong M = 8 earthquake, Shanxi Province are synthesized and discussed in the paper. If Taigu fault, Mianshan west-side fault and Huoshan piedmont fault were contemporarily active during the 1303 Hongtong M = 8 earthquake, the surface rupture zone would be 160 km long and could be divided into 3 segments, that is, the 50-km-long Huoshan piedmont fault segment, 35-km-long Mianshan west-side fault segment and 70-km-long Taigu fault segment, respectively. Among them, there exist 4 km and 8 km step regions. The surface rupture zone exhibits right-lateral features. The displacements of northern and central segments are respectively 6~7 m and the southern segment has the maximum displacement of 10 m. The single basin-boundary fault of Shanxi fault-depression system usually corresponds to M 7 earthquake, while this great earthquake (M = 8) broke through the obstacle between two basins. It shows that the surface rupture scale of great earthquake is changeable.展开更多
Objective： To study the effect and implication ofnonmyeloablative donor specific bone marrow （DSBM） infusion on the immunoreaction of liver allotransplantation. Methods： Orthotopic liver transplantation model was ...Objective： To study the effect and implication ofnonmyeloablative donor specific bone marrow （DSBM） infusion on the immunoreaction of liver allotransplantation. Methods： Orthotopic liver transplantation model was used in this study. Groups were set as follows： Group I, syngeneic control （Wistar-to-Wistar）; Group II, acute rejection （SD-to-Wistar）; Group III, acute rejection treated with cyclosporine A （CsA） by intramuscular injection （SD-to-Wistar＋CsA）; Group IV, bone marrow infusion at 7 d pretransplantation followed by short-term CsA treatment （SD-to-Wistar＋DSBM）; Another group of short-term CsA treatment preoperatively without bone marrow infusion was also set as control. General characteristics and survival time were observed. Histological grades of rejection were determined by pathological examination. IL-2 and IFN-7 level in peripheral blood and donor liver were detected respectively by Enzyme-Linked Immuno-Sorbent Assay （ELISA） and Western blot. Chimerism of donor cells was measured by PCR for a male-specific marker （Y-chromosome-specific sequence, Sry）. Results： No signs of rejection were found in Group Ⅰ. Acute rejection occurred in both Group Ⅱ and the short-term CsA treated group. All the recipients died at （9-15） d posttransplantation with a median survival time of （10.7i0.5） d and （11.2±2.4） d, respectively. Only mild rejection could be seen in Group Ⅲ. In Group Ⅳ, 4 out of 6 recipients had long-term survival （〉100 d）, the histological grade of rejection was significantly lower than that of Group Ⅱ, so did the expression level of IL-2 and IFN-7 in both peripheral blood and grafted liver. Y-chromosome-specific sequence （Sry） of male SD rats could be detected in the bone marrow, spleen and thymus of female recipients at 15 d after bone marrow infusion. Conclusion： Mild preconditioning nonmyeloablative donor specific bone marrow infusion can enhance chimerism formation in recipients, alleviate the rejection of liver allotransplantation and prolong survival of liver allotransplantation.展开更多
Objective To observe the effects of chronic emotional stress on the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and malonialdehyde (MDA) level in female rats’ brain. Methods The rats ...Objective To observe the effects of chronic emotional stress on the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and malonialdehyde (MDA) level in female rats’ brain. Methods The rats were randomly divided into 4 groups: normal control group (group N), emotional stress group (group E), emotional stress + pregnancy group (group E+P) and regularly drinking group (group R). Emotional stress in rats was induced by training rats with empty drinking bottles. Having been finished the stress procedure, the brain was taken out and homogenized. Then the activities of SOD, GSH-Px and MDA level were measured. Results Compared to group N, both the activities of SOD in brain tissues of group E and group E+P were significantly decreased ( P <0.05 and P <0.01, respectively) while the MDA level increased ( P <0.05). However, the extent of changes in group E+P was more obvious than that in E. GSH-Px activities in E+P and E were significantly changed. However, the GSH-Px activity in E+P was decreased ( P <0.05) while the activity in E increased ( P <0.05).Conclusion The chronic emotional stress can reduce the antioxidative system by decreasing the antioxidative enzyme activity and potentiating the lipid peroxidation in the brain. It is also suggested that the combination of emotional stress and pregnancy can augment the oxidative damage in rats’ brain.展开更多
The paper introduces the method of high-density seismic imaging exploration, discusses its features different from conventional shallow seismic reflection wave technique, and illustrates the application effect of the ...The paper introduces the method of high-density seismic imaging exploration, discusses its features different from conventional shallow seismic reflection wave technique, and illustrates the application effect of the method using three samples of engineering geological explorations on land and in water exploration of underground cavity, location survey of sunk ship and investigation of channel silt depth.展开更多
On the basis of the sufficient consideration of vectorial characteristics of stress, a new nonlinear constitutive model for cohesionless soil under plane strain and 3-D conditions was presented in a way that the actio...On the basis of the sufficient consideration of vectorial characteristics of stress, a new nonlinear constitutive model for cohesionless soil under plane strain and 3-D conditions was presented in a way that the action effects of stress vector are decomposed into the action effect of mean effective stress and that of the stress ratio vector (ratio of deviatoric stress vector to mean effective stress). The constitutive model can take account of the influence of both numerical and directional changes of stress vector on deformation of soil simultaneously, and is applicable of both static and dynamic loading.展开更多
The cycle of G-protein activation and deactivation is a key in the signaling pathway of GPCRs (G protein coupled receptors). GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by increasing the rates...The cycle of G-protein activation and deactivation is a key in the signaling pathway of GPCRs (G protein coupled receptors). GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by increasing the rates at which the (subunits hydrolyze bound GTP to GDP. RGSs (regulators of G protein signaling) is a novel family and, in most cases, implicated in accelerating the hydrolysis of GTP. The opioid receptors are all seven serpentine transmembrane receptors coupled with G proteins Gi, Go, even Gs. Adenylate cyclase (AC) is展开更多
According to the analysis on the characteristics of historic earthquakes in Jiangsu Province and South Huanghai Sea region, the historical earthquakes in the studied area are divided into two kinds of comparatively sa...According to the analysis on the characteristics of historic earthquakes in Jiangsu Province and South Huanghai Sea region, the historical earthquakes in the studied area are divided into two kinds of comparatively safe class and comparatively dangerous class. Then the statistical result of earthquake class, the characteristics of geo-graphical distribution and geological structures are studied. The study shows: a) In Jiangsu Province and South Huanghai Sea region, the majority of historical strong earthquakes belong to comparatively safe class, only 13.8% belong to comparatively dangerous class; b) Most historical earthquakes belong to comparatively safe class in the land area of Jiangsu, eastern sea area of Yangtze River mouth and northern depression of South Huanghai Sea region. However, along the coast of middle Jiangsu Province and in the sea area of South Huanghai Sea, the distribution of historical earthquake classes is complex and the earthquake series of comparatively dan-gerous class and comparatively safe class are equivalent in number; c) In the studied area, the statistical results of historical earthquake classes and the characteristics of spatial distribution accord very well with the real case of present-day earthquake series. It shows that the seismic activity in the region has the characteristic of succession, and the result from this study can be used as a reference for early postseismic judgment in the earthquake emer-gency work in Jiangsu Province.展开更多
A simple and efficient procedure for synthesis of 1-hydroxymethylene-1,1-bisphos- phoates from aldehydes is described. This method was applied to the synthesis of novel catechol substituted bisphosphonates as the a...A simple and efficient procedure for synthesis of 1-hydroxymethylene-1,1-bisphos- phoates from aldehydes is described. This method was applied to the synthesis of novel catechol substituted bisphosphonates as the anti-osteoporosis agents.展开更多
A Novel segmentation and feedback model (SFM) applied to resolve collision has been proposed. The SFM is featured with Burst Segmentation and Prioritized Feedback (BSPF) that are used to provide quality of service (Qo...A Novel segmentation and feedback model (SFM) applied to resolve collision has been proposed. The SFM is featured with Burst Segmentation and Prioritized Feedback (BSPF) that are used to provide quality of service (QoS) and realize high throughput and faster switching in the optical burst switched networks. Simulation and performance analyses show that the SFM effectively avoid collision in optical burst switching (OBS). Long delay time of deflection routing and immature technology of wavelength converter and optical buffer are not employed in the SFM. The SFM not only realizes quick switching but also allows preemption for higher priority bursts.展开更多
文摘The synthesis problem of a 6-SPS Stewart platform with semi-regular hexagons is studied in this paper. We present a genetic algorithm approach to synthesize a Stewart platform whose workspace must include a desired workspace with orienting capabilities in a given 3D region. Based on the observation that the constant orientation workspace gets smaller as the given orientations increase, a simple method is presented to describe the workspace with orienting capabilities, which need only search the constant orientation workspaces with the eight sets of extremal orientations of given 3D region and use their common part.To verify the method, a numerical example is given. The GA is used to optimize architectural parameters and obtain a compact manipulator. The method is applied to synthesize a Stewart platform whose workspace must include a prescribed cylinder with orienting capabilities.
文摘Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of life in PADAM patients. Methods： Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function （IIEF） scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen （PSA）, etc., and the data before treatment were compared with those after treatment in the same group. Results： After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85±0.36 before treatment and 5.02±0.83 after treatmnet （P〈0.05）; luteinizing hormone of 7.33±2.14 and 4.84±1.43 （P〈0.01）, follicule-stimulating hormone of 10.22±4.48 and 6.47±3.28 （P〈0.01）, respectively. The level of PSA failed to change significantly （1.94±0.55 and 2.06±0.47, P〉0.05）. Conclusion： JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.
基金Joint Seismological Science Foundation of China (No. 201017).
文摘When the resultant of applied forces does not pass through the center of an active landmass, the landmass will rotate, giving rise to a rotational tectonic stress field. The motion of a fault along the principal stress plane is de-termined by the mechanic features of the plane. Tensile fractures occur on the faults in the direction of the principal extensional stress plane, and fault-depression basins will be formed under a long-term action. Thrusting and over-thrusting occur on faults in the direction of the principal compressional stress plane, or folds may be formed as a result. Information on geology shows that the North China landmass, which remained stable and intact for a long time, became disjointed in the Eogene period. In the course of disjunction, anticlockwise rotation took place in the Shanxi-Hebei-Shaanxi (Jin-Ji-Shan) landmass, giving rise to the fault-depression system in its periphery. In the Pliocene epoch the landmass lost stability and its eastern boundary moved westward. As a result, the Shanxi gra-ben system appeared and Ordos landmass was formed. Structural and mechanic features of the main faults around Jin-Ji-Shan landmass can be explained with principal stress plane of a rotational tectonic stress field.
基金Joint Seismological Science Foundation of China (No. 201017).
文摘Based on the latest displacement of Huoshan piedmont fault, Mianshan west-side fault and Taigu fault obtained from the beginning of 1990s up to the present, the characteristics of distribution and displacement of surface rup-ture zone of the 1303 Hongtong M = 8 earthquake, Shanxi Province are synthesized and discussed in the paper. If Taigu fault, Mianshan west-side fault and Huoshan piedmont fault were contemporarily active during the 1303 Hongtong M = 8 earthquake, the surface rupture zone would be 160 km long and could be divided into 3 segments, that is, the 50-km-long Huoshan piedmont fault segment, 35-km-long Mianshan west-side fault segment and 70-km-long Taigu fault segment, respectively. Among them, there exist 4 km and 8 km step regions. The surface rupture zone exhibits right-lateral features. The displacements of northern and central segments are respectively 6~7 m and the southern segment has the maximum displacement of 10 m. The single basin-boundary fault of Shanxi fault-depression system usually corresponds to M 7 earthquake, while this great earthquake (M = 8) broke through the obstacle between two basins. It shows that the surface rupture scale of great earthquake is changeable.
文摘Objective： To study the effect and implication ofnonmyeloablative donor specific bone marrow （DSBM） infusion on the immunoreaction of liver allotransplantation. Methods： Orthotopic liver transplantation model was used in this study. Groups were set as follows： Group I, syngeneic control （Wistar-to-Wistar）; Group II, acute rejection （SD-to-Wistar）; Group III, acute rejection treated with cyclosporine A （CsA） by intramuscular injection （SD-to-Wistar＋CsA）; Group IV, bone marrow infusion at 7 d pretransplantation followed by short-term CsA treatment （SD-to-Wistar＋DSBM）; Another group of short-term CsA treatment preoperatively without bone marrow infusion was also set as control. General characteristics and survival time were observed. Histological grades of rejection were determined by pathological examination. IL-2 and IFN-7 level in peripheral blood and donor liver were detected respectively by Enzyme-Linked Immuno-Sorbent Assay （ELISA） and Western blot. Chimerism of donor cells was measured by PCR for a male-specific marker （Y-chromosome-specific sequence, Sry）. Results： No signs of rejection were found in Group Ⅰ. Acute rejection occurred in both Group Ⅱ and the short-term CsA treated group. All the recipients died at （9-15） d posttransplantation with a median survival time of （10.7i0.5） d and （11.2±2.4） d, respectively. Only mild rejection could be seen in Group Ⅲ. In Group Ⅳ, 4 out of 6 recipients had long-term survival （〉100 d）, the histological grade of rejection was significantly lower than that of Group Ⅱ, so did the expression level of IL-2 and IFN-7 in both peripheral blood and grafted liver. Y-chromosome-specific sequence （Sry） of male SD rats could be detected in the bone marrow, spleen and thymus of female recipients at 15 d after bone marrow infusion. Conclusion： Mild preconditioning nonmyeloablative donor specific bone marrow infusion can enhance chimerism formation in recipients, alleviate the rejection of liver allotransplantation and prolong survival of liver allotransplantation.
文摘Objective To observe the effects of chronic emotional stress on the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and malonialdehyde (MDA) level in female rats’ brain. Methods The rats were randomly divided into 4 groups: normal control group (group N), emotional stress group (group E), emotional stress + pregnancy group (group E+P) and regularly drinking group (group R). Emotional stress in rats was induced by training rats with empty drinking bottles. Having been finished the stress procedure, the brain was taken out and homogenized. Then the activities of SOD, GSH-Px and MDA level were measured. Results Compared to group N, both the activities of SOD in brain tissues of group E and group E+P were significantly decreased ( P <0.05 and P <0.01, respectively) while the MDA level increased ( P <0.05). However, the extent of changes in group E+P was more obvious than that in E. GSH-Px activities in E+P and E were significantly changed. However, the GSH-Px activity in E+P was decreased ( P <0.05) while the activity in E increased ( P <0.05).Conclusion The chronic emotional stress can reduce the antioxidative system by decreasing the antioxidative enzyme activity and potentiating the lipid peroxidation in the brain. It is also suggested that the combination of emotional stress and pregnancy can augment the oxidative damage in rats’ brain.
文摘The paper introduces the method of high-density seismic imaging exploration, discusses its features different from conventional shallow seismic reflection wave technique, and illustrates the application effect of the method using three samples of engineering geological explorations on land and in water exploration of underground cavity, location survey of sunk ship and investigation of channel silt depth.
文摘On the basis of the sufficient consideration of vectorial characteristics of stress, a new nonlinear constitutive model for cohesionless soil under plane strain and 3-D conditions was presented in a way that the action effects of stress vector are decomposed into the action effect of mean effective stress and that of the stress ratio vector (ratio of deviatoric stress vector to mean effective stress). The constitutive model can take account of the influence of both numerical and directional changes of stress vector on deformation of soil simultaneously, and is applicable of both static and dynamic loading.
文摘The cycle of G-protein activation and deactivation is a key in the signaling pathway of GPCRs (G protein coupled receptors). GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by increasing the rates at which the (subunits hydrolyze bound GTP to GDP. RGSs (regulators of G protein signaling) is a novel family and, in most cases, implicated in accelerating the hydrolysis of GTP. The opioid receptors are all seven serpentine transmembrane receptors coupled with G proteins Gi, Go, even Gs. Adenylate cyclase (AC) is
文摘According to the analysis on the characteristics of historic earthquakes in Jiangsu Province and South Huanghai Sea region, the historical earthquakes in the studied area are divided into two kinds of comparatively safe class and comparatively dangerous class. Then the statistical result of earthquake class, the characteristics of geo-graphical distribution and geological structures are studied. The study shows: a) In Jiangsu Province and South Huanghai Sea region, the majority of historical strong earthquakes belong to comparatively safe class, only 13.8% belong to comparatively dangerous class; b) Most historical earthquakes belong to comparatively safe class in the land area of Jiangsu, eastern sea area of Yangtze River mouth and northern depression of South Huanghai Sea region. However, along the coast of middle Jiangsu Province and in the sea area of South Huanghai Sea, the distribution of historical earthquake classes is complex and the earthquake series of comparatively dan-gerous class and comparatively safe class are equivalent in number; c) In the studied area, the statistical results of historical earthquake classes and the characteristics of spatial distribution accord very well with the real case of present-day earthquake series. It shows that the seismic activity in the region has the characteristic of succession, and the result from this study can be used as a reference for early postseismic judgment in the earthquake emer-gency work in Jiangsu Province.
文摘A simple and efficient procedure for synthesis of 1-hydroxymethylene-1,1-bisphos- phoates from aldehydes is described. This method was applied to the synthesis of novel catechol substituted bisphosphonates as the anti-osteoporosis agents.
文摘A Novel segmentation and feedback model (SFM) applied to resolve collision has been proposed. The SFM is featured with Burst Segmentation and Prioritized Feedback (BSPF) that are used to provide quality of service (QoS) and realize high throughput and faster switching in the optical burst switched networks. Simulation and performance analyses show that the SFM effectively avoid collision in optical burst switching (OBS). Long delay time of deflection routing and immature technology of wavelength converter and optical buffer are not employed in the SFM. The SFM not only realizes quick switching but also allows preemption for higher priority bursts.
