胸腺五肽对肺癌模型小鼠免疫功能及脾脏TLR4信号通路的作用

目的:研究胸腺五肽对肺癌模型小鼠免疫功能及脾脏Toll样受体-4(TLR-4)信号通路的作用。方法:40只C57BL/6小鼠随机分为正常对照组、模型对照组、环磷酰胺组和胸腺五肽组,除正常对照组外其他3组小鼠制作肺癌模型。造模成功后各组小鼠治疗2周,然后测定血液调节性T细胞(Treg细胞)和辅助性T细胞17(Th17细胞)水平及脾脏组织中TLR4、肿瘤坏死因子受体相关因子-6(TRAF-6)、核因子-κB(NF-κB)、激活蛋白-1(AP-1)mRNA和蛋白表达。结果:(1)胸腺五肽组小鼠血液Treg细胞和Th17细胞水平显著高于环磷酰胺组(P<0.01),而Treg细胞/Th17细胞值显著低于模型对照组(P<0.01);(2)胸腺五肽组小鼠脾脏TLR4、TRAF-6、NF-κB、AP-1mRNA和蛋白表达水平显著低于环磷酰胺组(P<0.01)。结论:肺癌小鼠接受环磷酰胺化疗时辅以胸腺五肽治疗可调节其免疫功能,下调脾脏TLR4信号通路TLR4、TRAF-6、NF-κB及AP-1的表达。

一种胶带输送机转载点溜槽防撞击结构的研究与应用

在煤矿及选煤厂的运煤系统中,溜槽是车间输送、储存、转运、筛分、破碎设备之间的主要输送连接部件,这些部件在运煤系统运行时不断受到原煤煤流的冲刷、碰撞,极易造成壁板材料磨损、腐蚀、泄漏等,并且由于溜槽磨损、腐蚀后容易引发煤流在落煤管中的粘堵,严重影响运煤系统正常运行,污染运煤系统环境。同时,增加溜槽检修工作量及生产成本,影响企业安全生产。提出了一种防撞击溜槽结构设计方案,避免煤流直接冲击溜槽和刮板机箱体;根据ANSYS仿真软件1∶1模拟现场实际处理量进行模拟入料效果,其原理是侧向缓冲接煤,螺旋滑行降落,无死角、无积煤,充分利用运动煤块的动能和势能转化,自冲刷滑道,不挂煤,保持一定运动速度落煤。

Emergency Evacuation Plan of the Louvre Based on Cellular Automata Superposition Model

The Louvre is a famous French building and a tourist attraction.It is of great significance to make an emergency evacuation plan for tourists.A social force model and cellular automata were established to simulate the crowd evacuation in unidimensional plane,and then the downstairs model was considered to simulate three-dimensional evacuation.Finally the real evacuation situation was simulated,considering the hazard source as well as other factors.The study found that the exit was closer to the corner,and the evacuation distance of descending stairs could be controlled between 0.3 and 0.6 m to maximize evacuation efficiency.The influence of the hazard at the edge of the channel was greater than that at the center of the channel.Therefore,in the process of evacuation,the staff should be guided to the nearest exit,to maintain the optimal distance,the staff to eliminate the danger source in the center of the passage.

阿法替尼致非小细胞肺癌患者中毒性表皮坏死松解症1例

1病例资料患者,男性,76岁,于2022年2月3日以“痰中带血伴憋喘10h余”为主诉就诊于我院。CT示:双侧胸腔积液,左肺下叶占位;肺部肿物穿刺活检病理示:左下肺鳞状细胞癌。既往史:高血压病史6年,冠状动脉粥样硬化性心脏病病史、房颤病史、脑梗死病史1年余,前列腺增生病史1月余,规律服用依那普利、氯沙坦、地高辛、美托洛尔、华法林、阿司匹林、复方血栓通胶囊、前列舒通胶囊治疗,控制尚可,未见不适。诊断为:左肺下叶鳞癌(cT3N2M1aⅣA期)、纵隔淋巴结肿大、肺门淋巴结肿大、胸腔积液。