目的网状Meta分析艾迪注射剂联合化疗治疗胃癌的疗效性和安全性。方法计算机检索PubMed、Cochrane Library、EMBASE、Web of Science、中国学术期刊网络出版总库、中国生物医学文献数据库、中文科技期刊全文数据库、中国科学引文数据库...目的网状Meta分析艾迪注射剂联合化疗治疗胃癌的疗效性和安全性。方法计算机检索PubMed、Cochrane Library、EMBASE、Web of Science、中国学术期刊网络出版总库、中国生物医学文献数据库、中文科技期刊全文数据库、中国科学引文数据库和万方数据资源等数据库,同时检索会议论文和学位论文数据库,补充其他检索获取所有艾迪注射剂联合化疗治疗胃癌的随机对照试验,由2位评价者按纳入、排除标准独立筛选文献、提取资料并评价其方法学质量,用ADDIS和Review Manger软件分析。结果最终纳入符合标准的文献32篇,2009例患者,网状Meta分析结果显示:艾迪注射剂联合化疗治疗胃癌在提高患者治疗有效率和临床获益率、改善生活质量、降低口腔黏膜炎、肝功能异常、白细胞减少和恶心呕吐的发生率等方面的差异有统计学意义;概率排序联合不同化疗方案在有效率、生活质量改善率、恶心呕吐、白细胞减少(Ⅲ-Ⅳ)和腹泻等结局指标的疗效。结论艾迪注射剂联合化疗对于降低恶心呕吐和白细胞减少更具优势。展开更多
Background Genetic variations at the interleukin 28B （IL-28B） locus are important in predicting outcome following therapy for chronic hepatitis C virus （HCV） infection. The aim of this research was to evaluate the...Background Genetic variations at the interleukin 28B （IL-28B） locus are important in predicting outcome following therapy for chronic hepatitis C virus （HCV） infection. The aim of this research was to evaluate the role of IL-28B single nucleotide polymorphism （SNP） variations in Chinese patients undergoing pegylated interferon-a plus ribavirin （PEG-IFN-a/RBV） treatment. Methods To determine the effect of IL-28B variation on the response to HCV therapy, these variants were genotyped in a cohort of 220 patients who were chronically infected with HCV and received combined PEG-IFN-a/RBV therapy. Results The proportions of rs12979860 CC, CT, and TT genotypes were 71.4%, 25.0%, and 3.6% respectively, in the sustained virological response （SVR） group; 15.8%, 60.5%, and 23.7% respectively, in the null virological response （NVR） group; and 38.1%, 52.4%, and 9.5% respectively, in the relapse （Rel） group （P 〈0.05）. Logistic regression analysis showed that, compared to those having the CC genotype, CT heterozygotes had an increased risk of NVR and Rel （OR=10.95, 95% CI =4.12-29.11, P=1.5×10-7 and OR=3.93, 95% CI =1.86-8.32, P=-2.1×10-4 respectively）. The RNA quantification assay showed that patients with genotype CC exhibited much higher levels of IL-28 expression than those with genotype CT or TT （P 〈0.001）. Conclusions The IL-28B SNP rs12979860 genotype was related to the effectiveness of HCV therapy： patients with the CC rs12979860 genotype had higher rates of SVR than those with the CT or TT genotype, and the CC genotype revealed a significantly higher level of IL-28 mRNA expression.展开更多
文摘目的网状Meta分析艾迪注射剂联合化疗治疗胃癌的疗效性和安全性。方法计算机检索PubMed、Cochrane Library、EMBASE、Web of Science、中国学术期刊网络出版总库、中国生物医学文献数据库、中文科技期刊全文数据库、中国科学引文数据库和万方数据资源等数据库,同时检索会议论文和学位论文数据库,补充其他检索获取所有艾迪注射剂联合化疗治疗胃癌的随机对照试验,由2位评价者按纳入、排除标准独立筛选文献、提取资料并评价其方法学质量,用ADDIS和Review Manger软件分析。结果最终纳入符合标准的文献32篇,2009例患者,网状Meta分析结果显示:艾迪注射剂联合化疗治疗胃癌在提高患者治疗有效率和临床获益率、改善生活质量、降低口腔黏膜炎、肝功能异常、白细胞减少和恶心呕吐的发生率等方面的差异有统计学意义;概率排序联合不同化疗方案在有效率、生活质量改善率、恶心呕吐、白细胞减少(Ⅲ-Ⅳ)和腹泻等结局指标的疗效。结论艾迪注射剂联合化疗对于降低恶心呕吐和白细胞减少更具优势。
文摘Background Genetic variations at the interleukin 28B （IL-28B） locus are important in predicting outcome following therapy for chronic hepatitis C virus （HCV） infection. The aim of this research was to evaluate the role of IL-28B single nucleotide polymorphism （SNP） variations in Chinese patients undergoing pegylated interferon-a plus ribavirin （PEG-IFN-a/RBV） treatment. Methods To determine the effect of IL-28B variation on the response to HCV therapy, these variants were genotyped in a cohort of 220 patients who were chronically infected with HCV and received combined PEG-IFN-a/RBV therapy. Results The proportions of rs12979860 CC, CT, and TT genotypes were 71.4%, 25.0%, and 3.6% respectively, in the sustained virological response （SVR） group; 15.8%, 60.5%, and 23.7% respectively, in the null virological response （NVR） group; and 38.1%, 52.4%, and 9.5% respectively, in the relapse （Rel） group （P 〈0.05）. Logistic regression analysis showed that, compared to those having the CC genotype, CT heterozygotes had an increased risk of NVR and Rel （OR=10.95, 95% CI =4.12-29.11, P=1.5×10-7 and OR=3.93, 95% CI =1.86-8.32, P=-2.1×10-4 respectively）. The RNA quantification assay showed that patients with genotype CC exhibited much higher levels of IL-28 expression than those with genotype CT or TT （P 〈0.001）. Conclusions The IL-28B SNP rs12979860 genotype was related to the effectiveness of HCV therapy： patients with the CC rs12979860 genotype had higher rates of SVR than those with the CT or TT genotype, and the CC genotype revealed a significantly higher level of IL-28 mRNA expression.
