目的总结成人患者牙科焦虑预防及管理的最佳证据,为临床实践提供参考。方法检索中国知网、UpToDate、BMJ Best Practice、Cochrane Library、乔安娜布里格斯研究所循证卫生保健中心数据库、PsycINFO、CINAHL、PubMed、Web of Science等...目的总结成人患者牙科焦虑预防及管理的最佳证据,为临床实践提供参考。方法检索中国知网、UpToDate、BMJ Best Practice、Cochrane Library、乔安娜布里格斯研究所循证卫生保健中心数据库、PsycINFO、CINAHL、PubMed、Web of Science等数据库中关于成人患者牙科焦虑预防及管理的证据,包括临床决策、指南、系统评价、证据总结及专家共识等,检索时限为建库至2023年9月16日。对纳入的文献进行质量评价及证据提取和汇总。结果共纳入10篇文献,包括临床决策3篇、指南2篇、系统评价5篇。汇总了筛选与评估、预防、心理社会治疗、药物治疗、健康教育5个方面共29条最佳证据。结论该研究总结的成人患者牙科焦虑预防及管理的最佳证据较为全面,可供医护人员在临床中结合患者偏好使用,以改善成人患者牙科焦虑。展开更多
Liver fibrosis is characterized by chronic inflammatory responses and progressive fibrous scar formation.Macrophages play a central role in the pathogenesis of hepatic fibrosis by reconstructing the immune microenviro...Liver fibrosis is characterized by chronic inflammatory responses and progressive fibrous scar formation.Macrophages play a central role in the pathogenesis of hepatic fibrosis by reconstructing the immune microenvironment.Picroside Ⅱ(PIC Ⅱ),extracted from Picrorhizae Rhizoma,has demonstrated therapeutic potential for various liver damage.However,the mechanisms by which macrophage polarization initiates immune cascades and contributes to the development of liver fibrosis,and whether this process can be influenced by PIC Ⅱ,remain unclear.In the current study,RNA sequencing and multiple molecular approaches were utilized to explore the underlying mechanisms of PIC Ⅱ against liver fibrosis in multidrug-resistance protein 2 knockout(Mdr2^(−/−))mice.Our findings indicate that PIC Ⅱ activates M1-polarized macrophages to recruit natural killer cells(NK cells),potentially via the CXCL16-CXCR6 axis.Additionally,PIC Ⅱ promotes the apoptosis of activated hepatic stellate cells(aHSCs)and enhances the cytotoxic effects of NK cells,while also reducing the formation of neutrophil extracellular traps(NETs).Notably,the anti-hepatic fibrosis effects associated with PIC Ⅱ were largely reversed by macrophage depletion in Mdr2^(−/−)mice.Collectively,our research suggests that PIC Ⅱ is a potential candidate for halting the progression of liver fibrosis.展开更多
目的检索、评价和整合肿瘤患者输液港相关性血栓预防及管理的相关证据,为临床实践提供参考。方法使用计算机检索中国知网、BMJ Best Practice、UpToDate、Cochrane Library、乔安娜布里格斯研究所循证卫生保健中心数据库、CINAHL、Embas...目的检索、评价和整合肿瘤患者输液港相关性血栓预防及管理的相关证据,为临床实践提供参考。方法使用计算机检索中国知网、BMJ Best Practice、UpToDate、Cochrane Library、乔安娜布里格斯研究所循证卫生保健中心数据库、CINAHL、Embase、PubMed、中国临床指南文库、苏格兰院际指南网、美国国立指南库、美国输液护士协会网站、美国国家综合癌症网、美国临床肿瘤学会网站、欧洲肿瘤内科学会网站、安大略省注册护士协会网站中关于肿瘤患者输液港相关性血栓预防及管理的证据,包括指南、系统评价、证据总结、推荐实践及专家共识,检索时限为建库至2021年3月10日。结果共纳入12篇文献,包括指南4篇、系统评价5篇、证据总结1篇、专家共识2篇,从风险评估、导管置入与维护、血栓筛查与诊断、预防、管理与治疗、健康教育6个方面,共总结30条最佳证据。结论该研究总结了肿瘤患者输液港相关性血栓预防及管理的最佳证据。护士及护理管理者可结合临床情景及患者意愿选择并应用证据,以制订科学的肿瘤患者输液港相关性血栓预防及管理方案,提升护理质量。展开更多
文摘目的总结成人患者牙科焦虑预防及管理的最佳证据,为临床实践提供参考。方法检索中国知网、UpToDate、BMJ Best Practice、Cochrane Library、乔安娜布里格斯研究所循证卫生保健中心数据库、PsycINFO、CINAHL、PubMed、Web of Science等数据库中关于成人患者牙科焦虑预防及管理的证据,包括临床决策、指南、系统评价、证据总结及专家共识等,检索时限为建库至2023年9月16日。对纳入的文献进行质量评价及证据提取和汇总。结果共纳入10篇文献,包括临床决策3篇、指南2篇、系统评价5篇。汇总了筛选与评估、预防、心理社会治疗、药物治疗、健康教育5个方面共29条最佳证据。结论该研究总结的成人患者牙科焦虑预防及管理的最佳证据较为全面,可供医护人员在临床中结合患者偏好使用,以改善成人患者牙科焦虑。
基金supported by the National Key Research and Development Program on Modernization of Traditional Chinese Medicine(No.2022YFC3502100)the National Natural Science Foundation of China(No.82274186)+2 种基金the National High-Level Talents Special Support Programthe Young Talents Promotion Project of China Association of Traditional Chinese Medicine(No.2020-QNRC2-01)the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202006).
文摘Liver fibrosis is characterized by chronic inflammatory responses and progressive fibrous scar formation.Macrophages play a central role in the pathogenesis of hepatic fibrosis by reconstructing the immune microenvironment.Picroside Ⅱ(PIC Ⅱ),extracted from Picrorhizae Rhizoma,has demonstrated therapeutic potential for various liver damage.However,the mechanisms by which macrophage polarization initiates immune cascades and contributes to the development of liver fibrosis,and whether this process can be influenced by PIC Ⅱ,remain unclear.In the current study,RNA sequencing and multiple molecular approaches were utilized to explore the underlying mechanisms of PIC Ⅱ against liver fibrosis in multidrug-resistance protein 2 knockout(Mdr2^(−/−))mice.Our findings indicate that PIC Ⅱ activates M1-polarized macrophages to recruit natural killer cells(NK cells),potentially via the CXCL16-CXCR6 axis.Additionally,PIC Ⅱ promotes the apoptosis of activated hepatic stellate cells(aHSCs)and enhances the cytotoxic effects of NK cells,while also reducing the formation of neutrophil extracellular traps(NETs).Notably,the anti-hepatic fibrosis effects associated with PIC Ⅱ were largely reversed by macrophage depletion in Mdr2^(−/−)mice.Collectively,our research suggests that PIC Ⅱ is a potential candidate for halting the progression of liver fibrosis.
文摘目的检索、评价和整合肿瘤患者输液港相关性血栓预防及管理的相关证据,为临床实践提供参考。方法使用计算机检索中国知网、BMJ Best Practice、UpToDate、Cochrane Library、乔安娜布里格斯研究所循证卫生保健中心数据库、CINAHL、Embase、PubMed、中国临床指南文库、苏格兰院际指南网、美国国立指南库、美国输液护士协会网站、美国国家综合癌症网、美国临床肿瘤学会网站、欧洲肿瘤内科学会网站、安大略省注册护士协会网站中关于肿瘤患者输液港相关性血栓预防及管理的证据,包括指南、系统评价、证据总结、推荐实践及专家共识,检索时限为建库至2021年3月10日。结果共纳入12篇文献,包括指南4篇、系统评价5篇、证据总结1篇、专家共识2篇,从风险评估、导管置入与维护、血栓筛查与诊断、预防、管理与治疗、健康教育6个方面,共总结30条最佳证据。结论该研究总结了肿瘤患者输液港相关性血栓预防及管理的最佳证据。护士及护理管理者可结合临床情景及患者意愿选择并应用证据,以制订科学的肿瘤患者输液港相关性血栓预防及管理方案,提升护理质量。
