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HPLC-MS/MS检测小鼠脑部组胺和5-羟色胺 被引量:6
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作者 谢天发 刘长安 刘健 《合肥工业大学学报(自然科学版)》 CAS 北大核心 2018年第1期124-128,共5页
组胺和5-羟色胺(5-HT)与很多神经相关疾病联系密切,因此研究它们在脑组织中质量比的变化对该类疾病的诊断和治疗具有重要意义。文章通过高效液相色谱串联质谱法检测了小鼠脑组织中组胺质量比和5-羟色胺质量比水平,通过对脑组织样品前处... 组胺和5-羟色胺(5-HT)与很多神经相关疾病联系密切,因此研究它们在脑组织中质量比的变化对该类疾病的诊断和治疗具有重要意义。文章通过高效液相色谱串联质谱法检测了小鼠脑组织中组胺质量比和5-羟色胺质量比水平,通过对脑组织样品前处理方法的改进,对检测条件的选择和流动相条件的优化,确定了小鼠脑组织中组胺质量比和5-羟色胺质量比的检测方法。小鼠脑组织中的组胺和5-羟色胺的回收率分别为(83.5±2.4)%和(87.4±5.3)%;检测限均为0.1ng/mL。使用该方法检测野生型C57BL/6J小鼠和肥大细胞缺失小鼠Kit^(W-sh/W-sh)脑组织中组胺质量比和5-羟色胺质量比,结果显示,肥大细胞缺失后小鼠脑组织组胺质量比显著降低,而5-羟色胺质量比没有显著改变。 展开更多
关键词 高效液相色谱 质谱 肥大细胞 5-羟色胺(5-HT) 组胺
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Least Squares Model Averaging for Two Non-Nested Linear Models
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作者 GAO Yan xie tianfa ZOU Guohua 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2023年第1期412-432,共21页
This paper studies the least squares model averaging methods for two non-nested linear models.It is proved that the Mallows model averaging weight of the true model is root-n consistent.Then the authors develop a pena... This paper studies the least squares model averaging methods for two non-nested linear models.It is proved that the Mallows model averaging weight of the true model is root-n consistent.Then the authors develop a penalized Mallows criterion which ensures that the weight of the true model equals 1 with probability tending to 1 and thus the averaging estimator is asymptotically normal.If neither candidate model is true,the penalized Mallows averaging estimator is asymptotically optimal.Simulation results show the selection consistency of the penalized Mallows method and the superiority of the model averaging approach compared with the model selection estimation. 展开更多
关键词 Asymptotic optimality CONSISTENCY least squares model averaging non-nested models
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协变量有测量误差时Tobit回归模型的估计 被引量:1
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作者 牛娟 谢田法 +1 位作者 郭媛媛 孙志华 《系统科学与数学》 CSCD 北大核心 2020年第9期1672-1686,共15页
文章考虑协变量有测量误差时参数Tobit模型的估计问题.文章所提方法不需要假定测量误差模型的结构,不需要对测量误差变量的方差做假定,也不需要有重复观测的数据.测量误差的矫正通过借助工具变量来实现.首先利用非参数核光滑方法得到真... 文章考虑协变量有测量误差时参数Tobit模型的估计问题.文章所提方法不需要假定测量误差模型的结构,不需要对测量误差变量的方差做假定,也不需要有重复观测的数据.测量误差的矫正通过借助工具变量来实现.首先利用非参数核光滑方法得到真实观测变量的估计,然后用这个估计替代没有观察到的真实变量来处理测量误差.这样,模型的回归系数就可以利用校正的最小二乘方法来估计.文章给出了具体的算法,证明了回归模型的参数估计的渐近正态性.数值模拟结果表明文章提出的校正测量误差的方法比直接使用有测量误差数据的朴素方法有更好的有限样本性质. 展开更多
关键词 参数Tobit模型 测量误差 工具变量 渐近正态性
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协变量含误差和输出变量误分类时处理组平均处理效应的估计
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作者 魏少杰 谢田法 张忠占 《系统科学与数学》 CSCD 北大核心 2022年第10期2834-2846,共13页
经典的逆概率加权估计方法依赖于变量的精确测量,然而实际上这一条件有时得不到满足.文章研究了当协变量带有测量误差和输出变量误分类时,处理组平均处理效应的估计问题.基于纠偏的思想和条件得分方法,讨论了加权估计方法中加权函数的... 经典的逆概率加权估计方法依赖于变量的精确测量,然而实际上这一条件有时得不到满足.文章研究了当协变量带有测量误差和输出变量误分类时,处理组平均处理效应的估计问题.基于纠偏的思想和条件得分方法,讨论了加权估计方法中加权函数的构造和估计方法,并进一步给出了处理组平均处理效应的相合估计.模拟研究和实例分析表明了所提出方法的优越性. 展开更多
关键词 Rubin因果模型 测量误差 误分类 处理组平均处理效应 逆概率加权
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Statistical inference for right-censored data with nonignorable missing censoring indicators 被引量:1
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作者 SUN ZhiHua xie tianfa LIANG Hua 《Science China Mathematics》 SCIE 2013年第6期1263-1278,共16页
We consider the statistical inference for right-censored data when censoring indicators are missing but nonignorable, and propose an adjusted imputation product-limit estimator. The proposed estimator is shown to be c... We consider the statistical inference for right-censored data when censoring indicators are missing but nonignorable, and propose an adjusted imputation product-limit estimator. The proposed estimator is shown to be consistent and converges to a Gaussian process. Furthermore, we develop an empirical processbased testing method to check the MAR (missing at random) mechanism, and establish asymptotic properties for the proposed test statistic. To determine the critical value of the test, a consistent model-based bootstrap method is suggested. We conduct simulation studies to evaluate the numerical performance of the proposed method and compare it with existing methods. We also analyze a real data set from a breast cancer study for an illustration. 展开更多
关键词 右删失数据 统计推断 审查 测试方法 高斯过程 经验过程 测试统计 渐近性质
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Rank-Based Test for Partial Functional Linear Regression Models 被引量:1
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作者 xie tianfa CAO Ruiyuan YU Ping 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2020年第5期1571-1584,共14页
This paper investigates the hypothesis test of the parametric component in partial functional linear regression models.Based on a rank score function,the authors develop a rank test using functional principal componen... This paper investigates the hypothesis test of the parametric component in partial functional linear regression models.Based on a rank score function,the authors develop a rank test using functional principal component analysis,and establish the asymptotic properties of the resulting test under null and local alternative hypotheses.A simulation study shows that the proposed test procedure has good size and power with finite sample sizes.The authors also present an illustration through fitting the Berkeley Growth Data and testing the effect of gender on the height of kids. 展开更多
关键词 Asymptotic normality functional principal component analysis Karhunen-loève expansion local alternative hypothesis rank regression
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Estimation in Partially Observed Functional Linear Quantile Regression
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作者 XIAO Juxia xie tianfa ZHANG Zhongzhan 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2022年第1期313-341,共29页
Currently,working with partially observed functional data has attracted a greatly increasing attention,since there are many applications in which each functional curve may be observed only on a subset of a common doma... Currently,working with partially observed functional data has attracted a greatly increasing attention,since there are many applications in which each functional curve may be observed only on a subset of a common domain,and the incompleteness makes most existing methods for functional data analysis ineffective.In this paper,motivated by the appealing characteristics of conditional quantile regression,the authors consider the functional linear quantile regression,assuming the explanatory functions are observed partially on dense but discrete point grids of some random subintervals of the domain.A functional principal component analysis(FPCA)based estimator is proposed for the slope function,and the convergence rate of the estimator is investigated.In addition,the finite sample performance of the proposed estimator is evaluated through simulation studies and a real data application. 展开更多
关键词 Conditional quantile regression functional data analysis functional principal component analysis incomplete curves
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