脑小血管病(cerebral small vessel disease,CSVD)是指影响脑表面和脑内小血管(包括动脉、小动脉、毛细血管、小静脉和静脉)结构和功能的病理过程,占卒中的25%~30%,是年龄相关性和高血压相关性认知功能下降和残疾的主要原因。多项研究表...脑小血管病(cerebral small vessel disease,CSVD)是指影响脑表面和脑内小血管(包括动脉、小动脉、毛细血管、小静脉和静脉)结构和功能的病理过程,占卒中的25%~30%,是年龄相关性和高血压相关性认知功能下降和残疾的主要原因。多项研究表明,种族差异、血管危险因素、遗传因素和环境敏感性在CSVD的病因学中发挥着重要作用,遗传因素对CSVD有显著影响[1]。目前已报道的可以引起CSVD的特定单基因突变为NOTCH3、COL4A1/2、TREX1、HTRA1、ADA2、ABCC6、CTSA[2-3]。COL4A1发生常染色体显性或隐性突变。展开更多
[Objective] The study aims to optimize the extracting technology conditions of essential oil from Elsholtzia densa Benth. [Method] Essential oil was extracted from E. densa Benth using steam distillation, and the effe...[Objective] The study aims to optimize the extracting technology conditions of essential oil from Elsholtzia densa Benth. [Method] Essential oil was extracted from E. densa Benth using steam distillation, and the effects of four extracting factors (grain size of the medicinal herb, ultrasonic time, soaking time and ratio of the material to liquid) on the yield of essential oil extracted from E. densa Benth were analyzed through the orthogonal test. [Result] The optimized extraction process of essential oil from E. densa Benth was as follows: grain size of the medicinal herb 50 mesh, ultrasonic time 12 min, being soaked in the water for 6 h, and ratio of the material to liquid 1∶16 g/ml. Under the conditions, the average extracting rate of the essential oil was 0.407%. [Conclusion] The optimized extraction process of essential oil from E. densa Benth was simple and practicable, and its extracting rate was higher.展开更多
文摘脑小血管病(cerebral small vessel disease,CSVD)是指影响脑表面和脑内小血管(包括动脉、小动脉、毛细血管、小静脉和静脉)结构和功能的病理过程,占卒中的25%~30%,是年龄相关性和高血压相关性认知功能下降和残疾的主要原因。多项研究表明,种族差异、血管危险因素、遗传因素和环境敏感性在CSVD的病因学中发挥着重要作用,遗传因素对CSVD有显著影响[1]。目前已报道的可以引起CSVD的特定单基因突变为NOTCH3、COL4A1/2、TREX1、HTRA1、ADA2、ABCC6、CTSA[2-3]。COL4A1发生常染色体显性或隐性突变。
基金Supported by the Open Lab Project and Innovative Entrepreneurial Project of Institute of Chemical Engineering,Northwest University for NationalitiesFundamental Research Funds for the Central Universities( ZYZ2011063)
文摘[Objective] The study aims to optimize the extracting technology conditions of essential oil from Elsholtzia densa Benth. [Method] Essential oil was extracted from E. densa Benth using steam distillation, and the effects of four extracting factors (grain size of the medicinal herb, ultrasonic time, soaking time and ratio of the material to liquid) on the yield of essential oil extracted from E. densa Benth were analyzed through the orthogonal test. [Result] The optimized extraction process of essential oil from E. densa Benth was as follows: grain size of the medicinal herb 50 mesh, ultrasonic time 12 min, being soaked in the water for 6 h, and ratio of the material to liquid 1∶16 g/ml. Under the conditions, the average extracting rate of the essential oil was 0.407%. [Conclusion] The optimized extraction process of essential oil from E. densa Benth was simple and practicable, and its extracting rate was higher.
