血清微小RNA-92a、微小RNA-34a、微小RNA-181c水平对急性脑梗死诊断及预后评估有重要价值

目的:探究血清微小RNA-92a(miR-92a)、miR-34a、miR-181c诊断急性脑梗死(ACI)的价值,并分析各指标评估患者预后的临床意义。方法:选取ACI患者80例为研究组,另选取同期健康体检者80例为对照组。比较2组血清miR-92a、miR-34a、miR-181c水平,并比较研究组不同病情患者血清miR-92a、miR-34a、miR-181c水平,分析各指标与神经功能缺损程度、梗死体积的相关性,及对ACI的诊断价值,分析各指标对预后的评估价值。结果:研究组血清miR-92a、miR-34a、miR-181c水平高于对照组(P均<0.05);重度、中度和轻度神经功能缺损患者血清miR-92a、miR-34a、miR-181c水平依次降低(P均<0.05);梗死体积>10 cm^(3)、5~10 cm^(3)、<5 cm^(3)患者血清miR-92a、miR-34a、miR-181c水平依次降低(P均<0.05);ACI患者血清miR-92a、miR-34a、miR-181c水平与美国国立卫生研究院卒中量表(NIHSS)评分、梗死体积呈正相关(r=0.857、0.832;0.823、0.806;0.794、0.752,P均<0.05);血清miR-92a、miR-34a、miR-181c诊断ACI的曲线下面积(AUC)均>0.75,具有一定诊断效能,各指标联合诊断的AUC最大(0.927),最佳诊断敏感度、特异性分别为77.50%、95.00%;血清miR-92a、miR-34a、miR-181c阳性患者预后良好率(62.75%、65.52%、62.26%)低于阴性患者(89.66%、90.91%、92.59%,P均<0.05)。结论:联合检测血清miR-92a、miR-34a、miR-181c水平可辅助临床诊断ACI,且各指标表达水平与患者预后密切相关。

Leaching of vanadium and chromium from converter vanadium slag intensified with surface wettability

Technology intensified with surface wettability was introduced to leach vanadium and chromium from converter vanadium slag without roasting. Parameters affecting the leaching efficiency of vanadium and chromium were investigated： sulfuric acid concentration, MnOz-to-slag mass ratio, liquid-to-solid ratio, leaching time, leaching temperature, and sodium dodecyl sulfate （SDS）-to-slag mass ratio. The leaching efficiencies of vanadium and chromium were 33.46 % and 20.02 % higher in the presence of MnO2 and SDS, respectively, compared to the control. The leaching efficiencies of vanadium and chromium were 68.93 % and 30.74 %, respectively, under the optimum conditions： sulfuric acid concentration 40 wt%, MnOz-to-slag mass ratio 10.0 wt%, liquid-to-solid ratio 5：1 mL/g; 12 h; 90 ~C; and SDS-to-slag mass ratio 0.25 wt%. The analysis of the reaction mechanism in the leaching process indicates that MnO2 combined with protons （H＋） could oxidize low-valent vanadium and chromium; SDS could change the chemical behavior and decrease the surface tension of the aqueous solution to favor MnO2 oxidization.