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MicroRNAs在膀胱癌中的研究进展
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作者 彭正 张前进 +7 位作者 申智勇 石家齐 钟渠良 谢华 韩宇 李竖玉 程雯 张馨予 《泌尿外科杂志(电子版)》 2023年第2期78-81,共4页
膀胱癌作为泌尿系统中最常见的高侵袭性肿瘤之一,由于缺乏准确的生物标志物,导致其发病率和复发率都很高。MicroRNA(miRNA)一种非编码的微小RNA,可调节人类基因表达,参与细胞生长周期、发育增殖、凋亡和分化等。近年来越来越多的研究发... 膀胱癌作为泌尿系统中最常见的高侵袭性肿瘤之一,由于缺乏准确的生物标志物,导致其发病率和复发率都很高。MicroRNA(miRNA)一种非编码的微小RNA,可调节人类基因表达,参与细胞生长周期、发育增殖、凋亡和分化等。近年来越来越多的研究发现miRNA在膀胱癌的发生发展中出现异常表达的情况,同时靶向调节特定的基因或蛋白,很可能成为膀胱癌诊治的潜在生物标志物。很多研究发现不同种类的miRNA参与肿瘤的发生更像是网络系统,相互之间存在着各种联系,本文根据几种miRNA分别通过调控多种基因参与膀胱癌的机制及其作用进行阐述。 展开更多
关键词 MIRNA 膀胱癌 生物标记物
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Utilization of Genetic Diversity on Establishing Chinese Soybean (G.max0 Core Collection
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作者 QiuLijuan xiehua +5 位作者 ChangRuzhen LiWei WangWenhui ZhangBo ZhangMinghui FengZhongfu 《中国粮油学报》 EI CAS CSCD 北大核心 2002年第G00期15-21,共7页
Genetic diversity plays a very important role in establishing core collection.In this study,A total of 405 Chinese soybean accessions was selected from the preliminary core collection,which had 5 different ecotypes fr... Genetic diversity plays a very important role in establishing core collection.In this study,A total of 405 Chinese soybean accessions was selected from the preliminary core collection,which had 5 different ecotypes from three cultivation regions,including northeastern spring sowing soybean(NSpSS),huanghuai summer sowing soybean(HSuSS),southern spring sowing soybean(SSpSS),southern summer sowing soybean(SSuSS),southern autumn sowing soybean(SAuSS).The genetic diversities and genetic relationship of five ecotypes were analyzed at DNA level by using SSR markers in order to provide information for establishemnt of Chinese soybean core collection.A set of 67 SSR primers were used to analyze these accessions,and detected 502 alleles with averaged 7.49 alleles per locus.SAuSS appeared to be the highest number of alleles,HSuSS had the biggest genetic diversity indexes and NSpSS were lowest for both numbers of alleles and genetic diversity indexes among 5 ecotypes.Since five ecotypes differentiated obviously,various sampling strategy for establishing core collection should be adaped for different ecotypes based on the number of alleles and genetic diversity indexes. 展开更多
关键词 遗传多样性 大豆 种植 中国 区域性 品种
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Cellular distribution of arsenic and other elements in hyperaccumulator Pteris nervosa and their relations to arsenic accumulation 被引量:16
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作者 CHENTongbin HUANGZechun +2 位作者 HUANGYuying xiehua LIAOXiaoyong 《Chinese Science Bulletin》 SCIE EI CAS 2003年第15期1586-1591,共6页
Synchrotron radiation X-ray fluorescence spectroscopy (SRXRF) was used to study the cellular distri- butions of arsenic and other elements in root, petiole, pinna of a newly discovered arsenic hyperaccumulator, Pteris... Synchrotron radiation X-ray fluorescence spectroscopy (SRXRF) was used to study the cellular distri- butions of arsenic and other elements in root, petiole, pinna of a newly discovered arsenic hyperaccumulator, Pteris nervosa. It was shown that there was a trend in P. nervosa to transport arsenic from cortex tissue to vascular tissue in root, and keep arsenic in vascular during transportation in petiole, and transport arsenic from vascular tissue to adaxial cortex tissues in midrib of pinnae. More arsenic was accumulated in mesophyll than in epidermis in pinnae. The distributions of some elements, such as K, Ca, Mn, Fe, Cu, Zn, in petiole, midrib and pinna were similar to that of arsenic, indicating that those cations might cooperate with arsenic in those transportation processes; whereas the distributions of Cl and Br in pinna were the reverse of that of arsenic, indicating that those anions might compete with arsenic in pinna of P. nervosa. 展开更多
关键词 超量聚积植物 凤尾蕨属植物 X射线荧光光谱学 同步加速器
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