Mg-based hydrides are too stable and the kinetics of hydrogen absorption and desorption is not satisfactory.An efficient way to improve these shortcomings is to employ reactive ball milling to synthesize the nanocompo...Mg-based hydrides are too stable and the kinetics of hydrogen absorption and desorption is not satisfactory.An efficient way to improve these shortcomings is to employ reactive ball milling to synthesize the nanocomposite materials of Mg and additives.In this experiment,TiF_(3)was selected as an additive,and the mechanical milling method was employed to prepare the experimental alloys.The alloys used in this experiment were the as-cast Ce_(5)Mg_(85)Ni_(10),as-milled Ce_(5)Mg_(85)Ni_(10)and Ce_(5)Mg_(85)Ni_(10)+3 wt.%TiF3.The phase transformation,structural evolution,isothermal and non-isothermal hydrogenation and dehydrogenation performances of the alloys were inspected by XRD,SEM,TEM,Sievert apparatus,DSC and TGA.It revealed that nanocrystalline appeared in the as-milled samples.Compared with the as-cast alloy,ball milling made the particle dimension and grain size decrease dramatically and the defect density increase significantly.The addition of TiF_(3)made the surface of ball milling alloy particles markedly coarser and more irregular.Ball milling and adding TiF_(3)distinctly improved the activation and kinetics of the alloys.Moreover,ball milling along with TiF_(3)can decrease the onset dehydrogenation temperature of Mg-based hydrides and slightly ameliorate their thermodynamics.展开更多
Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response v...Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response varies among individuals.Genetic factor may play an important role in BIPN.Methods:A nextgeneration sequencing(NGS)panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy.mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR(RT-qPCR).Serum homocysteine(Hcy)levels were detected in 40 samples by chemiluminescent microparticle immunoassay(CMIA).Results:Compared with the non-BIPN group(n=89),a total of 8 significantly associated single nucleotide polymorphisms(SNPs)were identified in the BIPN group(n=115):MTHFR(rs1801131,rs1801133,rs17421511),EPHX1(rs1051740),MME(rs2016848),ALDH1A1(rs6151031),HTR7(rs1935349)and CYP2A6(rs8192720).The mRNA expression level of MTHFR in newly diagnosed patients with peripheral neuritis after treatment(NP group)was lower than that of newly diagnosed patients without peripheral neuritis after treatment(NnP group)(1.70±0.77 vs.2.81±0.97,p=0.009).Serum Hcy levels were significantly higher in BIPN group than in non-BIPN group(11.66±1.79μmol/L vs.8.52±3.29μmol/L,p=0.016)and healthy controls(11.66±1.79μmol/L vs.8.55±2.13μmol/L,p≤0.001).Conclusion:CYP2A6,EPHX1,MTHFR,ALDH1A1,HTR7,MME and BIPN are linked in Chinese MM patients.BIPN is more likely to occur in patients with lower MTHFR mRNA expression,which might result in higher serum Hcy levels.展开更多
Ensuring a stable power output from renewable energy sources,such as wind and solar energy,depends on the development of large-scale and long-duration energy storage devices.Zinc–bromine fl ow batteries(ZBFBs)have em...Ensuring a stable power output from renewable energy sources,such as wind and solar energy,depends on the development of large-scale and long-duration energy storage devices.Zinc–bromine fl ow batteries(ZBFBs)have emerged as cost-eff ective and high-energy-density solutions,replacing expensive all-vanadium fl ow batteries.However,uneven Zn deposition during charging results in the formation of problematic Zn dendrites,leading to mass transport polarization and self-discharge.Stable Zn plating and stripping are essential for the successful operation of high-areal-capacity ZBFBs.In this study,we successfully synthesized nitrogen and oxygen co-doped functional carbon felt(NOCF4)electrode through the oxidative polymerization of dopamine,followed by calcination under ambient conditions.The NOCF4 electrode eff ectively facilitates effi cient“shuttle deposition”of Zn during charging,signifi cantly enhancing the areal capacity of the electrode.Remarkably,ZBFBs utilizing NOCF4 as the anode material exhibited stable cycling performance for 40 cycles(approximately 240 h)at an areal capacity of 60 mA h/cm^(2).Even at a high areal capacity of 130 mA h/cm^(2),an impressive energy effi ciency of 76.98%was achieved.These fi ndings provide a promising pathway for the development of high-areal-capacity ZBFBs for advanced energy storage systems.展开更多
To study the impact of the trailing-edge wear on the vibrational behavior of wind-turbine blades,unworn blades and trailing-edge worn blades have been assessed through relevant modal tests.According to these experimen...To study the impact of the trailing-edge wear on the vibrational behavior of wind-turbine blades,unworn blades and trailing-edge worn blades have been assessed through relevant modal tests.According to these experiments,the natural frequencies of trailing-edge worn blades-1,-2,and-3 increase the most in the second to fourth order,thefifth order increases in the middle,and thefirst order increases the least.The damping ratio data indi-cate that,in general,thefirstfive-order damping ratios of trailing-edge worn blades-1 and trailing-edge worn blades-2 are reduced,and thefirstfive-order damping ratios of trailing-edge worn blades-3 are slightly improved.The mode shape diagram shows that the trailing-edge worn blades-1 and-2 have a large swing in the tip and the blade,whereas the second-and third-order vibration shapes of the trailing edge-worn blade-3 tend to be improved.Overall,all these results reveal that the blade’s mass and the wear area are the main fac-tors affecting the vibration characteristics of wind turbine blades.展开更多
Massive content delivery will become one of the most prominent tasks of future B5G/6G communication.However,various multimedia applications possess huge differences in terms of object oriented(i.e.,machine or user)and...Massive content delivery will become one of the most prominent tasks of future B5G/6G communication.However,various multimedia applications possess huge differences in terms of object oriented(i.e.,machine or user)and corresponding quality evaluation metric,which will significantly impact the design of encoding or decoding within content delivery strategy.To get over this dilemma,we firstly integrate the digital twin into the edge networks to accurately and timely capture Quality-of-Decision(QoD)or Quality-of-Experience(QoE)for the guidance of content delivery.Then,in terms of machinecentric communication,a QoD-driven compression mechanism is designed for video analytics via temporally lightweight frame classification and spatially uneven quality assignment,which can achieve a balance among decision-making,delivered content,and encoding latency.Finally,in terms of user-centric communication,by fully leveraging haptic physical properties and semantic correlations of heterogeneous streams,we develop a QoE-driven video enhancement scheme to supply high data fidelity.Numerical results demonstrate the remarkable performance improvement of massive content delivery.展开更多
基金the National Natural Science Foundation of China(Nos.51871125,51761032,52001005 and 51731002)Major Science and Technology Innovation Projects in Shandong Province(No.2019JZZY010320)for financial support of the work.
文摘Mg-based hydrides are too stable and the kinetics of hydrogen absorption and desorption is not satisfactory.An efficient way to improve these shortcomings is to employ reactive ball milling to synthesize the nanocomposite materials of Mg and additives.In this experiment,TiF_(3)was selected as an additive,and the mechanical milling method was employed to prepare the experimental alloys.The alloys used in this experiment were the as-cast Ce_(5)Mg_(85)Ni_(10),as-milled Ce_(5)Mg_(85)Ni_(10)and Ce_(5)Mg_(85)Ni_(10)+3 wt.%TiF3.The phase transformation,structural evolution,isothermal and non-isothermal hydrogenation and dehydrogenation performances of the alloys were inspected by XRD,SEM,TEM,Sievert apparatus,DSC and TGA.It revealed that nanocrystalline appeared in the as-milled samples.Compared with the as-cast alloy,ball milling made the particle dimension and grain size decrease dramatically and the defect density increase significantly.The addition of TiF_(3)made the surface of ball milling alloy particles markedly coarser and more irregular.Ball milling and adding TiF_(3)distinctly improved the activation and kinetics of the alloys.Moreover,ball milling along with TiF_(3)can decrease the onset dehydrogenation temperature of Mg-based hydrides and slightly ameliorate their thermodynamics.
基金supported by the“GZ Hematologic Malignancy MARKER GHROMOS of Education Department of Liaoning Province”Grant(Grant Number:07102).
文摘Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response varies among individuals.Genetic factor may play an important role in BIPN.Methods:A nextgeneration sequencing(NGS)panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy.mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR(RT-qPCR).Serum homocysteine(Hcy)levels were detected in 40 samples by chemiluminescent microparticle immunoassay(CMIA).Results:Compared with the non-BIPN group(n=89),a total of 8 significantly associated single nucleotide polymorphisms(SNPs)were identified in the BIPN group(n=115):MTHFR(rs1801131,rs1801133,rs17421511),EPHX1(rs1051740),MME(rs2016848),ALDH1A1(rs6151031),HTR7(rs1935349)and CYP2A6(rs8192720).The mRNA expression level of MTHFR in newly diagnosed patients with peripheral neuritis after treatment(NP group)was lower than that of newly diagnosed patients without peripheral neuritis after treatment(NnP group)(1.70±0.77 vs.2.81±0.97,p=0.009).Serum Hcy levels were significantly higher in BIPN group than in non-BIPN group(11.66±1.79μmol/L vs.8.52±3.29μmol/L,p=0.016)and healthy controls(11.66±1.79μmol/L vs.8.55±2.13μmol/L,p≤0.001).Conclusion:CYP2A6,EPHX1,MTHFR,ALDH1A1,HTR7,MME and BIPN are linked in Chinese MM patients.BIPN is more likely to occur in patients with lower MTHFR mRNA expression,which might result in higher serum Hcy levels.
基金supported by Natural Science Foundation of Anhui Higher Education Institution of China(2023AH051318).
文摘Ensuring a stable power output from renewable energy sources,such as wind and solar energy,depends on the development of large-scale and long-duration energy storage devices.Zinc–bromine fl ow batteries(ZBFBs)have emerged as cost-eff ective and high-energy-density solutions,replacing expensive all-vanadium fl ow batteries.However,uneven Zn deposition during charging results in the formation of problematic Zn dendrites,leading to mass transport polarization and self-discharge.Stable Zn plating and stripping are essential for the successful operation of high-areal-capacity ZBFBs.In this study,we successfully synthesized nitrogen and oxygen co-doped functional carbon felt(NOCF4)electrode through the oxidative polymerization of dopamine,followed by calcination under ambient conditions.The NOCF4 electrode eff ectively facilitates effi cient“shuttle deposition”of Zn during charging,signifi cantly enhancing the areal capacity of the electrode.Remarkably,ZBFBs utilizing NOCF4 as the anode material exhibited stable cycling performance for 40 cycles(approximately 240 h)at an areal capacity of 60 mA h/cm^(2).Even at a high areal capacity of 130 mA h/cm^(2),an impressive energy effi ciency of 76.98%was achieved.These fi ndings provide a promising pathway for the development of high-areal-capacity ZBFBs for advanced energy storage systems.
基金supported by the National Natural Science Foundation Project(Nos.51966018 and 51466015)the Key Research&Development Program of Xinjiang(Grant No.2022B01003).
文摘To study the impact of the trailing-edge wear on the vibrational behavior of wind-turbine blades,unworn blades and trailing-edge worn blades have been assessed through relevant modal tests.According to these experiments,the natural frequencies of trailing-edge worn blades-1,-2,and-3 increase the most in the second to fourth order,thefifth order increases in the middle,and thefirst order increases the least.The damping ratio data indi-cate that,in general,thefirstfive-order damping ratios of trailing-edge worn blades-1 and trailing-edge worn blades-2 are reduced,and thefirstfive-order damping ratios of trailing-edge worn blades-3 are slightly improved.The mode shape diagram shows that the trailing-edge worn blades-1 and-2 have a large swing in the tip and the blade,whereas the second-and third-order vibration shapes of the trailing edge-worn blade-3 tend to be improved.Overall,all these results reveal that the blade’s mass and the wear area are the main fac-tors affecting the vibration characteristics of wind turbine blades.
基金partly supported by the National Natural Science Foundation of China (Grants No.62231017 and No.62071254)the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Massive content delivery will become one of the most prominent tasks of future B5G/6G communication.However,various multimedia applications possess huge differences in terms of object oriented(i.e.,machine or user)and corresponding quality evaluation metric,which will significantly impact the design of encoding or decoding within content delivery strategy.To get over this dilemma,we firstly integrate the digital twin into the edge networks to accurately and timely capture Quality-of-Decision(QoD)or Quality-of-Experience(QoE)for the guidance of content delivery.Then,in terms of machinecentric communication,a QoD-driven compression mechanism is designed for video analytics via temporally lightweight frame classification and spatially uneven quality assignment,which can achieve a balance among decision-making,delivered content,and encoding latency.Finally,in terms of user-centric communication,by fully leveraging haptic physical properties and semantic correlations of heterogeneous streams,we develop a QoE-driven video enhancement scheme to supply high data fidelity.Numerical results demonstrate the remarkable performance improvement of massive content delivery.
