Meta-analysis of the efficacy of volar plate internal fixation versus closed reduction and external fixation in the treatment of adult distal radius fractures

Objective:To compare the efficacy of open reduction and volar locking plate internal fixation with closed reduction and external fixation in the treatment of distal radius fractures by using meta analysis.Methods:The databases of CNKI,Wanfang,Weipu,Chinese biomedical literature,Pubmed,Embase,and Cochrane Library were retrieved,and the randomized controlled studies that directly compared the efficacy of plate internal fixation and closed reduction external fixation in the treatment of distal radius fractures published publicly from the establishment of the database to April 2023 were collected.The two researchers independently screened the retrieved literature according to the inclusion and exclusion criteria,extracted data,used Cochrane risk bias assessment tool for quality assessment,and used RevMan 5.4 software for meta analysis.Results:A total of 10 randomized controlled trials were included,all of which were in English.There were 1042 patients in total,and 9 of them were rated as low risk.Meta analysis results showed that one year after the treatment of distal radius fracture with volar locking plate internal fixation,DASH score[MD=-5.64,95%CI(-7.21,-4.06),P<0.00001];One year later,PRWE score[MD=-5.90,95%CI(-8.88,-2.92),P=0.001];Palm flexion[MD=5.92,95%CI(1.29,10.55),P=0.01];Pronation[MD=2.48,95%CI(0.59,4.36),P=0.01];Postrotation[MD=4.73,95%CI(2.15,7.31),P=0.0003];Grip strength[MD=0.61,95%CI(0.12,1.10),P=0.02];palmar tilt angle[MD=9.84,95%CI(5.66,14.02),P<0.00001];Radial inclination[MD=4.33,95%CI(2.97,5.69),P<0.00001]was superior to closed reduction plaster or splint external fixation.One year later,the European Five dimensional Health Scale(EQ-5D-5L)score[MD=0.02,95%CI(-0.01,0.05),P=0.27];Back extension[MD=2.22,95%CI(-4.15,8.59),P=0.49];Ulnar deviation[MD=3.49,95%CI(-0.80,7.78),P=0.11];Radial deviation[MD=2.05,95%CI(-2.39,6.50),P=0.37];Ulnar variance[MD=-1.14,95%CI(-3.16,0.88),P=0.27];There was no significant difference in complications[MD=0.77,95%CI(0.54,1.10),P=0.16](P>0.05).Conclusion:Based on the current clinical data,internal fixation with volar locking plate is more conducive to mid-term DASH score and grip strength recovery than closed reduction plaster or splint external fixation,but there is no significant difference in the quality of life and complications of patients.For adult distal radius fractures,surgical indications should be carefully grasped,and non operative treatment should be given priority.

中医治疗反流性咽喉炎现状

中医治疗反流性咽喉炎注重在疾病发展的动态过程中,根据患者舌苔、脉象及主要症状确定证候及相应的中医治法,辨证用药以提高临床疗效。如辨证为肝胃不和证,治宜疏肝理气、和胃利咽;脾胃虚弱证,治宜健脾和胃、降逆利咽;肝胃郁热证,治宜清热降逆、化痰利咽;痰气交阻证,治宜化痰散结、行气利咽;胃阴亏虚证治宜滋阴润燥、生津利咽。目前,仍存在研究样本量较小,对中医治法归纳存在偏颇,且对反流性咽喉炎病因病机的研究、辨证分型、处方用药尚缺乏统一标准等不足之处,今后需进行更深入研究,完善不足,以期更好地指导临床用药。

中国大陆一个新记录种——卵孢原球盖菇

对采自广东云开山国家级自然保护区的标本进行研究,经鉴定为中国大陆新记录种——卵孢原球盖菇(Protostropharia ovalispora Yen W.Wang&S.S.Tzean)。根据标本的形态特征,并结合ITS分子系统学分析,描述了该物种的主要特征为菌盖凸镜形至扁半球形,表面具黏液;菌褶直生;菌柄表面黏;担孢子椭圆形至长椭圆形。

内蒙古地区牛乳腺炎粪肠球菌临床分离株全基因组测序与生物信息学分析

目的对内蒙古地区奶牛乳腺炎临床分离粪肠球菌(Enterococcus faecalis)的基因组进行测序,并预测和分析其生物信息学特征。方法本实验以“内蒙古自治区乳源性致病菌防控工程技术研究中心”分离的粪肠球菌临床分离菌株FC(BME1708)为对象,利用PacBio RS II平台进行全基因组测序,分别使用RNAmmer和tRNAscan-SE软件对菌株基因组中的rRNA和tRNA进行预测,并对测序基因序列进行数据分析、基因注释、耐药性及毒力因子分析。结果测序组装后结果显示,该菌株基因组大小为2934454 bp,其中包含5个双股环状质粒DNA、61个tRNA、12个rRNA,蛋白总数为3151个。耐药性及毒力因子基因预测结果显示,该菌株对庆大霉素、链霉素、β内酰胺、青霉素、四环素、万古霉素等27类抗生素耐药,存在cyl、esp、ace、gel、efaA等82个相关毒力因子。结论已将本次分离的粪肠球菌基因组测序结果登录于GenBank(登录号:CP028835.1),该实验结果将为后续致病及免疫调控机理研究,以及防控策略的制定提供了可靠的生物信息数据。