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Polygon search algorithm for ultra-compact multifunctional integrated photonics design
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作者 TE DU ZHENG PENG +7 位作者 PEIXIN HUANG ZHAOJIAN ZHANG HANSI MA xinpeng jiang JIE HUANG MINGYU LUO HONGXIN ZOU JUNBO YANG 《Photonics Research》 SCIE EI CAS CSCD 2024年第7期1527-1541,共15页
Ultra-compact multifunctional integrated photonic modules have great practical significance to photonic integrated circuits (PICs).However,the design effect and efficiency of the existing mainstream inverse design alg... Ultra-compact multifunctional integrated photonic modules have great practical significance to photonic integrated circuits (PICs).However,the design effect and efficiency of the existing mainstream inverse design algorithms are incompetent when designing these modules.We analyze their shortcomings in this task,and propose a new,to our knowledge,inverse design algorithm named polygon search (PS) algorithm to address these problems.We utilize the PS algorithm to design an integrated dual-channel mode-conversion-crossing waveguide module.This module integrates three functions:interconversion between TE_(0) and TE_(1),interconversion between TE_(0) and TE_(2),and channel crossing within only a 4μm×4μm footprint,and its performance is verified by experimental testing.It not only greatly reduces the total footprint of many PICs but also greatly improves their fabricating robustness.Furthermore,we propose a PS-designed mode mixer and a PS-designed bending waveguide,and connect them with the integrated modules to form a four-channel crossing-mode-division-multiplexing system.This system can provide multiple modes on the basis of channel crossing and transmit the output signal in the same direction in parallel within a single output waveguide,which significantly increases the communication bandwidth and decreases the footprint of PICs.At last,we demonstrate the effect and efficiency advantages of the PS algorithm over several mainstream inverse design algorithms by a comprehensive contrast experiment and explain these advantages in theory from several perspectives. 展开更多
关键词 waveguide MIXER algorithm
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单纯经胸超声心动图引导卵圆孔未闭封堵术早期安全性及有效性分析
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作者 姜新鹏 李晓明 +4 位作者 杨航 宫一宸 傅元豪 傅瑜 张喆 《中华脑血管病杂志(电子版)》 2023年第4期320-324,共5页
目的分析单纯经胸超声心动图(TTE)引导卵圆孔未闭(PFO)封堵术的早期安全性及有效性。方法回顾性分析2019年3月至2022年12月于北京大学第三医院行TTE引导PFO封堵术的患者资料,共纳入403例,其中脑卒中患者145例,偏头痛患者258例。观察围... 目的分析单纯经胸超声心动图(TTE)引导卵圆孔未闭(PFO)封堵术的早期安全性及有效性。方法回顾性分析2019年3月至2022年12月于北京大学第三医院行TTE引导PFO封堵术的患者资料,共纳入403例,其中脑卒中患者145例,偏头痛患者258例。观察围手术期及术后3个月严重手术并发症及脑卒中/短暂性脑缺血发作是否复发,评估手术的安全性;采用配对t检验比较术前及术后3个月偏头痛患者的缓解程度[头痛影响测评量表6(HIT6)评分、头痛持续时间、头痛发作频率],评估手术的有效性。结果403例PFO封堵术患者中,20例患者因鞘管无法通过而终止手术,手术成功率为95.04%(383/403);手术时间为(23.3±7.3)min;在严重手术并发症方面,发生心包积液者13例(3.23%,13/403)、冠状动脉气体栓塞者4例(0.99%,4/403),未见封堵器脱落移位、外周血管损伤等并发症。4例冠状动脉气体栓塞患者经对症处理后好转;13例心包积液患者中,11例经心包穿刺引流后好转,2例紧急开胸探查止血,术中发现均为左心耳穿孔,经对症处理后好转出院。所有患者完成术后3个月随访,未发现封堵器移位、心包积液、主动脉瓣关闭不全等并发症;脑卒中患者未发现脑卒中/短暂性脑缺血发作复发;偏头痛患者术后3个月HIT6评分、头痛发作频率、发作时间较术前均明显减少[(43.6±5.6)分vs(57.8±6.7)分;(2.4±0.6)次/月vs(6.4±2.3)次/月;(2.2±1.4)h/次vs(7.4±4.5)h/次],差异具有统计学意义(t=25.45、26.34、17.27,P均<0.001)。结论单纯TTE引导PFO封堵术是安全、有效的。 展开更多
关键词 卵圆孔未闭 介入治疗 经胸超声心动图
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New cyclometalated transition-metal based photosensitizers for singlet oxygen generation and photodynamic therapy 被引量:2
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作者 xinpeng jiang ningbo zhu +1 位作者 dahui zhao yuguo ma 《Science China Chemistry》 SCIE EI CAS CSCD 2016年第1期40-52,共13页
The aim of this review article is to introduce recent studies on an emergent class of singlet oxygen photosensitizers of potential applications to the photodynamic therapy,with a primary focus on the cyclometalated tr... The aim of this review article is to introduce recent studies on an emergent class of singlet oxygen photosensitizers of potential applications to the photodynamic therapy,with a primary focus on the cyclometalated transition-metal complexes.Singlet oxygen photosensitization performances of various cyclometalated Ir and Pt scaffolds are reviewed,and the general photophysical properties of relevant systems and the mechanisms of singlet oxygen production via photo-sensitization are also briefly discussed.Thus far,investigations of singlet oxygen sensitization by such Ir and Pt complexes are mainly carried out in organic solvents and under non-physiological conditions,while some research efforts have been made at examining the feasibility of applying pertinent cyclometalated complexes to photodynamic therapy. 展开更多
关键词 photosensitizer singlet oxygen photodynamic therapy cyclometalated transition-metal complexes
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光动力活性氧的研究进展 被引量:16
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作者 蒋昕鹏 戴志飞 《科学通报》 EI CAS CSCD 北大核心 2018年第18期1783-1802,共20页
在光动力疗法(photodynamic therapy,PDT)治疗癌症的过程中,由光敏剂介导产生的活性氧起到了关键作用.本文主要从PDT三要素(光、氧气、光敏剂)所涉及的光敏剂靶向性、光照频率转换、氧气递送等方面介绍了增加靶部位活性氧(reactive oxyg... 在光动力疗法(photodynamic therapy,PDT)治疗癌症的过程中,由光敏剂介导产生的活性氧起到了关键作用.本文主要从PDT三要素(光、氧气、光敏剂)所涉及的光敏剂靶向性、光照频率转换、氧气递送等方面介绍了增加靶部位活性氧(reactive oxygen species,ROS)的方法;总结了用于单线态氧直接检测的光电倍增管、单光子雪崩二极管、负反馈雪崩二极管检测器,以及间接检测单线态氧、羟基或超氧阴离子的新型荧光或化学探针;描述了ROS引发的从基因、蛋白质到细胞层面的凋亡信号通路以及免疫反应诱导肿瘤细胞凋亡的作用机制. 展开更多
关键词 光动力治疗 活性氧 单线态氧 光敏剂 检测 作用机制
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Topological multipolar corner state in a supercell metasurface and its interplay with two-dimensional materials 被引量:1
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作者 Zhaojian Zhang Junbo Yang +1 位作者 Te Du xinpeng jiang 《Photonics Research》 SCIE EI CAS CSCD 2022年第4期855-869,共15页
Second-order topological insulators(SOTIs) have recently attracted much attention due to their capability to support lower-dimensional topological states, namely, the corner states. Here, we demonstrate that properly ... Second-order topological insulators(SOTIs) have recently attracted much attention due to their capability to support lower-dimensional topological states, namely, the corner states. Here, we demonstrate that properly designed supercell metasurfaces can support photonic corner states, meanwhile further serving as an ideal platform for the implementations of topological polaritons and dynamically reconfigurable corner states by assembling two-dimensional materials. Such metasurfaces consist of an array of finite-sized SOTIs mimicking the twodimensional Su–Schrieffer–Heeger model. We reveal that the topological transition happens in unit cells without the bandgap, and nondegenerate multipolar corner states emerge in the supercell metasurface due to the inter-and intrasupercell coupling effects. Especially since these corner states are above the light line of the metasurface, we realize the collective stimulation of the two dipolar corner states and their superposition state via far-field excitation. By stacking monolayer hexagonal boron nitride film onto the metasurface, we further achieve the topological phonon polaritons through the strong coupling between the corner state and the phonon, which is confirmed by the Rabi splitting as well as anticrossing behavior emerging in the transmission spectra.Furthermore, we reveal the robustness of the corner state and strong coupling by introducing defects into the metasurface. Finally, tunable corner state and strong coupling with on-demand control are realized by assembling monolayer graphene onto the metasurface. Our theoretical study proposes a unique hybrid-material platform for topological polaritonics and reconfigurable topological photonics, which can promote large-area topological applications in practice. 展开更多
关键词 POLAR WHILE CORNER
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