地方高校开放实验室建设与管理探究

加强地方高校开放实验室建设与管理是培养适应时代发展的高素质人才的重要手段和途径。本文提出从开放管理理念、改善地方高校开放实验室的硬件条件、加强实验室队伍建设、实施网络信息化管理等方面改进地方高校开放实验室建设与管理思路。

Distribution and transformation behaviors of heavy metals during liquefaction process of sewage sludge in ethanol-water mixed solvents

Liquefaction of sewage sludge(SS)in ethanol-water cosolvents is a promising process for the preparation of bio-oil/biochar products.Effect of the combined use of ethanol and water on the distribution/transformation behaviors of heavy metals(HMs)contained in raw SS is a key issue on the safety and cleanness of above liquefaction process,which is explored in this study.The results show that pure ethanol facilitates the migration of HMs into biochar products.Pure water yields lower percentages of HMs in mobile/bioavailable speciation.Compared with sole solvent treatment,ethanol-water cosolvent causes a random/average effect on the distribution/transformation behaviors of HMs.After liquefaction of SS in pure water,the contamination degree of HMs is mitigated from high level(25.8(contamination factor))in raw SS to considerable grade(13.4)in biochar and the ecological risk is mitigated from moderate risk(164.5(risk index))to low risk(78.8).Liquefaction of SS in pure ethanol makes no difference to the pollution characteristics of HMs.The combined use of ethanol and water presents similar immobilization effects on HMs to pure water treatment.The contamination factor and risk index of HMs in biochars obtained in ethanol-water cosolvent treatment are 13.1-14.6(considerable grade)and 79.3-101.0(low risk),respectively.In order to further control the pollution of HMs,it is preferentially suggested to improve the liquefaction process of SS in ethanol-water mixed solvents by introducing conventional lignocellulosic/algal biomass,also known as co-liquefaction treatment.

急性脑出血患者骨桥蛋白、S-100β蛋白及基质金属蛋白酶-9水平变化及与神经功能恢复、预后的相关性分析

目的探讨急性脑出血患者骨桥蛋白(osteopontin,OPN)、S-100β蛋白及基质金属蛋白酶-9(Matrix metalloprotein-9,MMP-9)水平变化及与神经功能恢复、预后的相关性分析。方法2016年3月至2017年3月我院收治的32例急性脑出血患者为观察组;同时选取在本院进行健康体检人员34例为对照组。对比两组OPN、S-100β蛋白及MMP-9水平,并分析OPN、S-100β蛋白及MMP-9水平与急性脑出血患者神经功能、预后的关系。结果观察组OPN、S-100β蛋白及MMP-9水平均显著高于对照组(P<0.05);NIHSS评分≥6分的急性脑出血患者OPN、S-100β、MMP-9水平均明显高于NIHSS评分<6分患者(P<0.05);生存分析显示OPN<30 ng/ml、S-100β蛋白<0.5 ng/ml、MMP-9水平为40.5~55.6 ng/ml的患者中位生存期较长,Keplan-meier生存曲线存在差异(P<0.05);经非条件多因素Logistic回归模型进一步分析,得出OPN≥30 ng/ml、S-100β蛋白≥0.5 ng/ml、MMP-9<40.5 ng/ml或>55.6 ng/ml、NIHSS评分≥6分为影响急性脑出血患者预后的独立危险因素(P<0.05)。结论OPN、S-100β、MMP-9与患者神经功能与预后有着密切联系,可用来判断患者神经功能恢复程度,可作为评估患者预后的重要指标。