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基于瘤内和瘤周影像组学模型预测肝细胞癌微血管侵犯的临床应用价值:一项多中心研究
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作者 朱珠 郁义星 +5 位作者 陆健 许大波 张涛 方伟 陆心雨 顾文豪 《磁共振成像》 CAS CSCD 北大核心 2024年第8期132-138,共7页
目的本研究旨在评估瘤内和瘤周影像组学模型对肝细胞癌(hepatocellular carcinoma,HCC)微血管侵犯(microvascular invasion,MVI)的预测价值。材料与方法回顾性分析2016年至2023年间在三家医院经手术病理证实为HCC患者的钆塞酸二钠(Gd-EO... 目的本研究旨在评估瘤内和瘤周影像组学模型对肝细胞癌(hepatocellular carcinoma,HCC)微血管侵犯(microvascular invasion,MVI)的预测价值。材料与方法回顾性分析2016年至2023年间在三家医院经手术病理证实为HCC患者的钆塞酸二钠(Gd-EOB-DTPA)增强MRI图像,以及性别、年龄、肿瘤最大径、甲胎蛋白(alpha-fetoprotein,AFP)、丙氨酸转氨酶(alanine aminotransferase,ALT)、天冬氨酸转氨酶(aspartate aminotransferase,AST)和有无乙肝7项临床信息。在动脉期、门静脉期和肝胆期图像中勾画瘤内及瘤周5 mm、10 mm感兴趣区域(region of interest,ROI),从中提取影像组学特征;训练集中,运用多因素logistic回归分析筛选MVI的独立临床预测因素;应用支持向量机(support vector machine,SVM)建立瘤内模型、瘤周模型、瘤内联合瘤周模型、临床模型和临床影像组学模型共10种模型,采用受试者工作特征(receiver operating characteristic,ROC)曲线评估模型的预测能力,以DeLong检验比较各模型ROC曲线下面积(area under the curve,AUC)的差异。结果肿瘤最大直径[优势比(odds ratio,OR):1.449,95%置信区间(confidence interval,CI):1.212~1.733]及AFP(OR:1.645,95%CI:0.665~4.071)是基于训练集的MVI独立临床预测因子。验证集中,临床模型、瘤内模型、瘤周模型、瘤内+瘤周模型及临床影像组学模型预测HCC MVI的AUC值分别为0.728、0.764~0.820、0.791~0.795、0.804~0.828和0.747,瘤内+瘤周5 mm模型、瘤内+瘤周10 mm模型的AUC值分别为0.828(95%CI:0.728~0.929)、0.804(95%CI:0.696~0.913)。各模型中,瘤内+瘤周5 mm模型与临床模型、临床影像组学模型的AUC差异具有统计学意义(P=0.039,0.028),其余模型间的AUC差异均无统计学意义(P>0.05)。结论基于Gd-EOB-DTPA增强MRI影像组学模型可用于术前预测HCC MVI,其中瘤内+瘤周5 mm模型对HCC MVI有较高的预测能力,可为临床制订个体化治疗方案提供依据。 展开更多
关键词 影像组学 磁共振成像 钆塞酸二钠 微血管侵犯 肝细胞癌
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Attitude Regulation of Flexible Spacecrafts with Unknown Control Directions and Input Disturbances
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作者 WU Haiwen xu dabo 《Journal of Systems Science & Complexity》 SCIE EI 2024年第6期2347-2367,共21页
In this paper,the authors address the attitude regulation problem of uncertain flexible spacecraft with unknown control directions and input disturbances.The major challenges of the problem include the concurrence of ... In this paper,the authors address the attitude regulation problem of uncertain flexible spacecraft with unknown control directions and input disturbances.The major challenges of the problem include the concurrence of the unknown actuation sign and the unknown parameters in both the plant and the external disturbances,along with the impact of vibrations from flexible appendages.To overcome these challenges,the authors transform the conventional mathematical model of a flexible spacecraft to a multivariable strict-feedback normal form and adopt a systematic approach within the framework of nonlinear output regulation.To solve the attitude regulation and disturbance rejection problem,the authors introduce a nonlinear internal model candidate to convert the problem into a stabilization problem for an augmented system.Then,a Nussbaum function-based stabilizer is designed to handle unknown control directions and complete the design.Simulation results are provided to show the effectiveness of the proposed controller. 展开更多
关键词 Attitude control disturbance rejection internal model Nussbaum functions
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Trajectory Tracking Control of Euler-Lagrange Systems with ISS-Like Robustness to Actuator Noises 被引量:2
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作者 WU Haiwen xu dabo 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2022年第5期1719-1747,共29页
This paper studies global robust tracking of uncertain Euler-Lagrange systems with input disturbances.The authors develop a robust regulation-based approach for the problem.Specifically,by introducing a novel nonlinea... This paper studies global robust tracking of uncertain Euler-Lagrange systems with input disturbances.The authors develop a robust regulation-based approach for the problem.Specifically,by introducing a novel nonlinear internal model,the authors solve global asymptotic trajectory tracking with disturbance rejection of multiple step/sinusoidal signals with unknown amplitudes,frequencies,and phases.Moreover,the authors show that a robustness property to actuator noises can be guaranteed in a sense of strong integral input-to-state stability(iISS).That is,the closed-loop system is not only i ISS but also input-to-state stable(ISS)to small magnitude actuator noises.Furthermore,the authors explore a by-product overparametrized linear regression estimation,coming up with robust estimation of the unknown parameters.Finally,the authors present several numerical examples to illustrate the theoretical results. 展开更多
关键词 Disturbance rejection Euler-Lagrange systems nonlinear control robust control trajectory tracking
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