目的:探究全程化药学服务在慢性病患者长期合理用药中的应用。方法:选取2020年12月至2022年12月玉山县黄家驷医院诊治的慢性病患者80例为研究对象,随机分为施行常规用药指导的对照组40例及施行全程化药学服务的观察组40例。分别于干预...目的:探究全程化药学服务在慢性病患者长期合理用药中的应用。方法:选取2020年12月至2022年12月玉山县黄家驷医院诊治的慢性病患者80例为研究对象,随机分为施行常规用药指导的对照组40例及施行全程化药学服务的观察组40例。分别于干预前、干预后采用Morisky依从性问卷(8-item Morisky Medication Adherence Scale,MMAS-8)、WHO生存质量量表(Methods:The WHO Quality of Life Brief Scale,WHOQOL-BREF)评估依从性及生活质量的变化,并记录用药期间安全性(用药期间出现的总不良反应)。结果:与干预前相比,干预1 m及3 m后各治疗组的MMAS-8评分均明显增加(P<0.05),其中以观察组更为显著(P<0.05);与干预前相比,干预后各治疗组WHOQOL-BREF评分(生理、心理、社交及环境评分)均明显增加(P<0.05),其中以观察组更为显著(P<0.05);干预期间,观察组患者不良反应发生率(2.50%)低于对照组(17.50%),差异有统计学意义(P<0.05)。结论:经对比分析发现全程化药学服务用于慢性病患者院外长期合理用药中,不仅能提高患者治疗依从性,还能降低不良反应发生风险,对于提高生活质量水平也具有积极作用。展开更多
2,6-Ditert-butylphenol （2,6-DTBP） is a major organic contaminant presenting in acrylic fiber manufacturing wastewaters. This compound is of high bio-resistance due to its complex structure which consists of one phen...2,6-Ditert-butylphenol （2,6-DTBP） is a major organic contaminant presenting in acrylic fiber manufacturing wastewaters. This compound is of high bio-resistance due to its complex structure which consists of one phenol group and two highly branched tert-butyl groups. This research attempted to improve the biodegradation efficiency of 2,6-DTBP through various strain immobilization methods. The stratified immobilization can settle oxygen transmission in the single microorganism immobilization, and can realize two-process reaction in the single device by choosing two symbiotic microorganisms. Two effective strains, named F-1-4 and F-3-4, which were screened out in our previous work, were used to degrade 2,6-DTBP after being immobilized in calcium alginate gel. Results indicate that the substrate removal efficiency of various immobilization methods follows the order： stratified 〉 single F-3-4 〉 mixed ≈single F-1-4. The immobilized biodegradation capacity was higher than the free one. After an incubation time of 12 d, 91% of 2,6-DTBP could be degraded by the stratified immobilization method, compared to 79% achieved by the mixed immobilization method with an initial 2,6-DTBP concentration of 100 mg/L. The stratified immobilization satisfies the oxygen demand nature of the aerobic F-3-4 and the facultative F-1-4, thus yielding the highest degradation efficiency. Both the outer layer strain F-3-4 and the inner layer strain F-1-4 can grow actively on the substrate of 2,6-DTBP, as illustrated by SEM images. This study shows that the highly bio-refractory compound, 2,6-DTBP, can be effectively degraded using appropriately inunobilized microorganism strains.展开更多
文摘目的:探究全程化药学服务在慢性病患者长期合理用药中的应用。方法:选取2020年12月至2022年12月玉山县黄家驷医院诊治的慢性病患者80例为研究对象,随机分为施行常规用药指导的对照组40例及施行全程化药学服务的观察组40例。分别于干预前、干预后采用Morisky依从性问卷(8-item Morisky Medication Adherence Scale,MMAS-8)、WHO生存质量量表(Methods:The WHO Quality of Life Brief Scale,WHOQOL-BREF)评估依从性及生活质量的变化,并记录用药期间安全性(用药期间出现的总不良反应)。结果:与干预前相比,干预1 m及3 m后各治疗组的MMAS-8评分均明显增加(P<0.05),其中以观察组更为显著(P<0.05);与干预前相比,干预后各治疗组WHOQOL-BREF评分(生理、心理、社交及环境评分)均明显增加(P<0.05),其中以观察组更为显著(P<0.05);干预期间,观察组患者不良反应发生率(2.50%)低于对照组(17.50%),差异有统计学意义(P<0.05)。结论:经对比分析发现全程化药学服务用于慢性病患者院外长期合理用药中,不仅能提高患者治疗依从性,还能降低不良反应发生风险,对于提高生活质量水平也具有积极作用。
文摘2,6-Ditert-butylphenol （2,6-DTBP） is a major organic contaminant presenting in acrylic fiber manufacturing wastewaters. This compound is of high bio-resistance due to its complex structure which consists of one phenol group and two highly branched tert-butyl groups. This research attempted to improve the biodegradation efficiency of 2,6-DTBP through various strain immobilization methods. The stratified immobilization can settle oxygen transmission in the single microorganism immobilization, and can realize two-process reaction in the single device by choosing two symbiotic microorganisms. Two effective strains, named F-1-4 and F-3-4, which were screened out in our previous work, were used to degrade 2,6-DTBP after being immobilized in calcium alginate gel. Results indicate that the substrate removal efficiency of various immobilization methods follows the order： stratified 〉 single F-3-4 〉 mixed ≈single F-1-4. The immobilized biodegradation capacity was higher than the free one. After an incubation time of 12 d, 91% of 2,6-DTBP could be degraded by the stratified immobilization method, compared to 79% achieved by the mixed immobilization method with an initial 2,6-DTBP concentration of 100 mg/L. The stratified immobilization satisfies the oxygen demand nature of the aerobic F-3-4 and the facultative F-1-4, thus yielding the highest degradation efficiency. Both the outer layer strain F-3-4 and the inner layer strain F-1-4 can grow actively on the substrate of 2,6-DTBP, as illustrated by SEM images. This study shows that the highly bio-refractory compound, 2,6-DTBP, can be effectively degraded using appropriately inunobilized microorganism strains.
