新工科背景下“思政+创新创业+专业”三位一体化工类创新人才培养模式的构建与实践

新工科背景下,化工行业迫切需要适应并能引领产业发展的新型工程技术人员。因此,作为新形势下的高等工程教育,迫切需要构建学科交叉与跨界融合的课程体系及培育德才兼备的新化工专业复合型人才。本文从新工科的理念入手,针对许多高校存在的思政教育、创新创业教育及专业教育三者在实施过程中未能实现同频共振、合力育人的现状,从大思想教育体系的专业培养角度出发探索我校三位一体化工类创新人才培养模式的构建与实践,为更好地建设新工科化工专业提供建设性的意见。

城乡统筹发展下我国农村公共体育服务体系的构建与优化

城乡发展不平衡导致城乡差距加大,针对中国的实际国情出发,坚持统筹发展的发展战略,有利于协调发展,有利于改善农村面貌.在全面推进扶贫工作的今天,农村扶贫任务依然很艰巨.增强农民的体质,改善农民的健身环境,提高农民体育健身的意识.从农村公共体育服务体系的内涵出发,分析了农村公共体育服务存在的问题:农村体育公共服务供给不足,体育公共服务投入不合理,政策法规的不完善,体质监测未普及,体育信息咨询需求不对等,体育指导短缺等等.并针对存在的问题提出农村公共体育服务体系的构建与优化的具体措施.

血友病性关节炎行全膝置换术患者康复治疗的效果

目的探讨康复治疗在行全膝关节置换术血友病性关节炎患者中的应用效果。方法 选取血友病性膝关节炎患者10例(14例膝),均行全膝关节置换术。根据患者情况制定术前及术后康复治疗计划,并分别于术前及术后1、3、6个月通过测量关节活动度、膝关节HSS功能评分对患者关节功能恢复情况进行评价。结果 10例患者康复治疗后伸膝角度、膝关节HSS功能评分均较术前明显改善( P <0.05),屈膝角度与术前比较差异无统计学意义( P >0.05)。所有患者术后均未出现关节内出血、切口感染、假体松动及下肢深静脉血栓等不良并发症,且术后3个月膝关节功能均达优良标准(HSS评分>80分)。结论 在控制患者出血风险的前提下,对行全膝关节置换术血友病性关节炎患者进行康复治疗安全可行,能够帮助患者恢复关节活动度及患肢功能。

Research and application of mechanical models for the whole process of 110 mining method roof structural movement

For the 110 mining method,it is challenging to accurately calculate the support resistance of the roadway due to the lack of understanding of the dynamic movement of the overlying strata in this method.The consequential excessive support results in a significant increase in the cost of roadway support.The authors explored the overlying strata movement and roadway deformation of the gob-entry retaining in the 110 mining method to solve this problem.First,the typical stages of the roof-cutting gob-side entry were defined.Second,the mechanical model and calculation formula of the support resistance on the roof were explored.Then,using numerical simulation software,the starting ranges of the specific supports at different stages were verified and the feasibility of the support scheme was examined.Finally,combined with the field measurement data,the stress and the deformation of the gob roadway at different stages under the influence of two mining processes in the 110 mining method were obtained.The numerical simulation results obtained are consistent with the field test results,providing a theoretical basis for precision support at different stages by the 110 mining method.

Two New Furostanol Saponins from Tribulus Terrestris L.

Two new furostanol glucosides, named tribufurosides G and H, were isolated from Tribulus terrestris L. The structures of the two new furostanol glucosides were elucidated as 26-O-β-D-glucopyranosyl-（25R）-5α-furost12-one-3β,22α,26-tetraol-3-O-β-D-glucopyranosyl-（ 1→2 ）-β-D-glucopyranosyl-（ 1→4 ）-β-D-galactopyranoside（ 1 ） and 26-O-β-D-glucopyranosyl-（25S）-5 α- 12-one-2 α,3,8,22 α,26-tetraol-3 -O-β-D-glucopyranosyl-（ 1 → 2 ）-β-D-glucopyranosyl-（1→4）-β-D-galactopyranoside（2） by 1 D, 2D NMR techniques, ESI-MS analysis as well as chemical methods.

嗜酸性筋膜炎1例报道

引起肢体硬化的疾病并不多,其中系统性硬化症(systemic sclerosis,SSc)是最为周知的病因,还有一个疾病也会出现肢体硬化的表现——嗜酸性筋膜炎(eosinophilic fasciitis,EF)。EF 比SSc 更为少见,两者存在诸多不同之处。笔者报道1 例男性EF 患者,同时将之与SSc 进行对比鉴别,以期引起更多临床医生对这个疾病的认识,因为延误治疗不仅加重肢体的硬化,还会引起关节挛缩甚至可能致残。

A New Furospirostanol Saponin,Ophiofurospiside B from Ophiopogon japonicus(Thunb.) Ker-Gawl

Introduction The tuber of Ophiopogon japonicus （ L. f） Ker- Gawl, which is a Chinese traditional medicine named ＂maidong＂ have been recorded to have various medical functions for curing cardiovascular diseases and bacterial infections, especially heart diseases. Phytochemical studies on this plant were reported previously. In search of new and bioactive components from Chinese traditional medicines, the tubers of Ophiopogon japonicus have been investigated in this study. The present paper article covers the isolation and structure elucidation of a new furospirostanol saponin, namely, Ophiofurospiside B （compound 1 ） and two known steroidal saponins （ compounds 2 and 3）.

Application of excavation compensation method for enhancing stability and efficiency in shallow large-span rock tunnels

Engineering shallow,large-span rock tunnels challenges deformation control and escalates construction costs.This study investigates the excavation compensation method(ECM)and its associated technologies to address these issues.Utilizing five key technologies,the ECM effectively modulates radial stress post-excavation,redistributes stress in the surrounding rock,and eliminates tensile stress at the excavation face.Pre-tensioning measures further enhance the rock’s residual strength,establishing a new stability equilibrium.Field tests corroborate the method’s effectiveness,demonstrating a crown settlement reduction of 3–8 mm,a nearly 50%decrease compared to conventional construction approaches.Additionally,material consumption and construction duration were reduced by approximately 30%–35%and 1.75 months per 100 m,respectively.Thus,the ECM represents a significant innovation in enhancing the stability and construction efficiency of large-span rock tunnels,marking a novel contribution to the engineering field.

Chemical constituents from the stems of Gymnema sylvestre

AIM: To study the chemical constituents of stems of Gymnema sylvestre(Retz.) Schult. METHODS: Chromatographic techniques using silica gel, C18 reversed phase silica gel, and prep-HPLC were used. The structures were elucidated on the basis of MS and spectroscopic analysis(1D and 2D NMR), as well as chemical methods. RESULTS: Seven compounds were isolated and their structures were elucidated as conduritol A(1), stigmasterol(2), lupeol(3), stigmasterol-3-O-β-D-glucoside(4), the sodium salt of 22α-hydroxy-longispinogenin-3-O-β-D-glucopyranosyl-(1→3)-β-D-glucurono-pyranosyl-28-O-α-L-rhamnopyranoside(5), oleanolic acid-3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside(6), and the sodium salt of 22α-hydroxy-longispinogenin 3-O-β-D-glucuronopyranosyl-28-O-α-L-rhamnopyranoside(7). The inhibition activities of compounds 1, 5-7 on non-enzymatic glycation of protein in vitro were evaluated. CONCLUSION: Compound 7 is a new triterpenoid saponin. It was shown that compounds 1, 5-7 have weak inhibition activities for non-enzymatic glycation of protein in vitro.