黄精皂苷(Saponin of Rhizoma Polygonati)是黄精药理作用的活性成分之一,主要包括甾体皂苷类和三萜皂苷类等79种化合物。总结了近年来黄精皂苷的提取方法;综合评价了其在调节免疫力、抗抑郁、改善记忆力、抗肿瘤、降血糖、抗炎、抑菌...黄精皂苷(Saponin of Rhizoma Polygonati)是黄精药理作用的活性成分之一,主要包括甾体皂苷类和三萜皂苷类等79种化合物。总结了近年来黄精皂苷的提取方法;综合评价了其在调节免疫力、抗抑郁、改善记忆力、抗肿瘤、降血糖、抗炎、抑菌、抗病毒等多个方面的药理活性作用。指出其发展不足,并进行了综合的展望,以期为黄精皂苷的深入研究与综合利用提供参考和理论基础。展开更多
Diamide derivatives are biologically active molecules that have been widely applied in recent years in research on pesticides,especially insecticides.Using a simple and environmentally friendly scheme,a series of new ...Diamide derivatives are biologically active molecules that have been widely applied in recent years in research on pesticides,especially insecticides.Using a simple and environmentally friendly scheme,a series of new diamide derivatives containing a trifluoromethylpyridine skeleton was designed,synthesized,and confirmed by^(1)H,^(19)F and^(13)C NMR,and HR-MS.Their insecticidal activities against Plutella xylostella and Helicoverpa armigera were measured and the relationship between structure and activity was investigated.Eight of the title compounds(D2,D5,D10,D21,D28,D29,D30 and D33)showed 100%activity against P.xylostella at 500 mg L^(-1).One compound,D33,still showed 100%activity against P.xylostella at 100 mg L^(-1)and had the lowest LC_(50)(lethal concentration 50%,3.7 mg L^(-1))among the synthesized compounds.Molecular docking analysis revealed that D33 could be thoroughly embedded in the active pocket of the ryanodine receptor via hydrogen bonding in a manner similar to the commercial insecticide chlorantraniliprole.展开更多
文摘黄精皂苷(Saponin of Rhizoma Polygonati)是黄精药理作用的活性成分之一,主要包括甾体皂苷类和三萜皂苷类等79种化合物。总结了近年来黄精皂苷的提取方法;综合评价了其在调节免疫力、抗抑郁、改善记忆力、抗肿瘤、降血糖、抗炎、抑菌、抗病毒等多个方面的药理活性作用。指出其发展不足,并进行了综合的展望,以期为黄精皂苷的深入研究与综合利用提供参考和理论基础。
基金supported by the National Natural Science Foundation of China (21762012, 32072445 and 21562012)the Program of Introducing Talents to Chinese Universities (D20023)the S&T Planning Project of Guizhou Province, China ([2017]1402 and [2017]5788)
文摘Diamide derivatives are biologically active molecules that have been widely applied in recent years in research on pesticides,especially insecticides.Using a simple and environmentally friendly scheme,a series of new diamide derivatives containing a trifluoromethylpyridine skeleton was designed,synthesized,and confirmed by^(1)H,^(19)F and^(13)C NMR,and HR-MS.Their insecticidal activities against Plutella xylostella and Helicoverpa armigera were measured and the relationship between structure and activity was investigated.Eight of the title compounds(D2,D5,D10,D21,D28,D29,D30 and D33)showed 100%activity against P.xylostella at 500 mg L^(-1).One compound,D33,still showed 100%activity against P.xylostella at 100 mg L^(-1)and had the lowest LC_(50)(lethal concentration 50%,3.7 mg L^(-1))among the synthesized compounds.Molecular docking analysis revealed that D33 could be thoroughly embedded in the active pocket of the ryanodine receptor via hydrogen bonding in a manner similar to the commercial insecticide chlorantraniliprole.
