We present experimental observations of soliton pulsations in the net normal-dispersion fiber laser by using the dispersive Fourier transform(DFT) technique. According to the pulsating characteristics, the soliton pul...We present experimental observations of soliton pulsations in the net normal-dispersion fiber laser by using the dispersive Fourier transform(DFT) technique. According to the pulsating characteristics, the soliton pulsations are classified as visible and invisible soliton pulsations. The visible soliton pulsation is converted from single-into dual-soliton pulsation with the common characteristics of energy oscillation and bandwidth breathing. The invisible soliton pulsation undergoes periodic variation in the spectral profile and peak power but remains invariable in pulse energy. The reason for invisible soliton pulsation behavior is periodic oscillation of the pulse inside the soliton molecule. These results could be helpful in deepening our understanding of the soliton pulsation phenomena.展开更多
Aim: To observe effects of angiotensin (Ang) II receptor antagonist (AT1) irbesartan and angiotensin-converting enzyme (ACE) inhibitor perindopril on rat myocardium calcineurin expression and sarcoplasmic reticulum Ca...Aim: To observe effects of angiotensin (Ang) II receptor antagonist (AT1) irbesartan and angiotensin-converting enzyme (ACE) inhibitor perindopril on rat myocardium calcineurin expression and sarcoplasmic reticulum Ca2+-ATPase activity in the model of pressure-overload cardiac hypertrophy. Methods: Forty male adult Sprague Dawley rats were divided into 5 groups. One group was treated by sham operation; four groups were myocardium hypertrophy cases caused by banding aortic above renal artery. Drugs were given one week after operation. Group 1: sham group, rats (n=8) were gavaged with normal saline 2 ml/(kg·d) (ig); Group 2: control group, rats (n=8) were treated with normal saline 2 ml/(kg·d) (ig); Group 3: rats (n=8) were given perindopril 2 mg/(kg·d) (ig); Group 4: rats (n=8) were treated with irbesartan 20 mg/(kg·d) (ig); Group 5: rats (n=8) were given irbesartan 20 mg/(kg·d) plus perindopril 2 mg/(kg·d) (ig). Morphometric determination, calcineurin expression and sarcoplasmic reticulum Ca2+-ATPase activity were done at the end of 6 week of drug intervention. Expression of calcineurin in myocardium was detected by immunohistochemistry. Results: Left ventricular mass index (LVMI), transverse diameter of myocardial cell (TDM), cal-cineurin activity were remarkably decreased after drug intervention and this decrease was most remarkable in the combination drug therapy group. Sarcoplasmic reticulum Ca2+-ATPase activity was increased after drug intervention, especially in the com-bined drug therapy group. Calcineurin expression in myocardium was remarkably decreased after drug intervention. LVMI was positively correlated with TDM and calcineurin, negatively correlated with sarcoplasmic reticulum Ca2+-ATPase. Conclusion: These data suggest that irbesartan and perindopril inhibit cardiac hypertrophy through the increased activity of sarcoplasmic reticulum Ca2+-ATPase and decreased expression of calcineurin. Their combination had better effects on regressing of ventricular hypertrophy.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 41875040)the Natural Science Foundation of Anhui Province, China (Grant No. 2008085MF211)+1 种基金the Foundation for Young Talents in College of Anhui Province, China (Grant No. gxyqZD2019034)the Innovation Fund for Postgraduates of Huaibei Normal University, China (Grant No. CX2022035)。
文摘We present experimental observations of soliton pulsations in the net normal-dispersion fiber laser by using the dispersive Fourier transform(DFT) technique. According to the pulsating characteristics, the soliton pulsations are classified as visible and invisible soliton pulsations. The visible soliton pulsation is converted from single-into dual-soliton pulsation with the common characteristics of energy oscillation and bandwidth breathing. The invisible soliton pulsation undergoes periodic variation in the spectral profile and peak power but remains invariable in pulse energy. The reason for invisible soliton pulsation behavior is periodic oscillation of the pulse inside the soliton molecule. These results could be helpful in deepening our understanding of the soliton pulsation phenomena.
基金Supported by the National Natural Science Foundation of China(Grant No.51479153)the Fundamental Research Funds for the Central Uni.(Grant No.2016-YB-014)
文摘Aim: To observe effects of angiotensin (Ang) II receptor antagonist (AT1) irbesartan and angiotensin-converting enzyme (ACE) inhibitor perindopril on rat myocardium calcineurin expression and sarcoplasmic reticulum Ca2+-ATPase activity in the model of pressure-overload cardiac hypertrophy. Methods: Forty male adult Sprague Dawley rats were divided into 5 groups. One group was treated by sham operation; four groups were myocardium hypertrophy cases caused by banding aortic above renal artery. Drugs were given one week after operation. Group 1: sham group, rats (n=8) were gavaged with normal saline 2 ml/(kg·d) (ig); Group 2: control group, rats (n=8) were treated with normal saline 2 ml/(kg·d) (ig); Group 3: rats (n=8) were given perindopril 2 mg/(kg·d) (ig); Group 4: rats (n=8) were treated with irbesartan 20 mg/(kg·d) (ig); Group 5: rats (n=8) were given irbesartan 20 mg/(kg·d) plus perindopril 2 mg/(kg·d) (ig). Morphometric determination, calcineurin expression and sarcoplasmic reticulum Ca2+-ATPase activity were done at the end of 6 week of drug intervention. Expression of calcineurin in myocardium was detected by immunohistochemistry. Results: Left ventricular mass index (LVMI), transverse diameter of myocardial cell (TDM), cal-cineurin activity were remarkably decreased after drug intervention and this decrease was most remarkable in the combination drug therapy group. Sarcoplasmic reticulum Ca2+-ATPase activity was increased after drug intervention, especially in the com-bined drug therapy group. Calcineurin expression in myocardium was remarkably decreased after drug intervention. LVMI was positively correlated with TDM and calcineurin, negatively correlated with sarcoplasmic reticulum Ca2+-ATPase. Conclusion: These data suggest that irbesartan and perindopril inhibit cardiac hypertrophy through the increased activity of sarcoplasmic reticulum Ca2+-ATPase and decreased expression of calcineurin. Their combination had better effects on regressing of ventricular hypertrophy.
