为了研究水下超声速喷射流流场压力脉动特性及其对上浮水雷的受力影响特性,基于VOF(Volume of fluid)多相流模型,建立了上浮水雷在不同工作状态(欠膨胀、完全膨胀、过膨胀)下的数值计算模型,研究了水下燃气喷射流对上浮水雷的受力特性...为了研究水下超声速喷射流流场压力脉动特性及其对上浮水雷的受力影响特性,基于VOF(Volume of fluid)多相流模型,建立了上浮水雷在不同工作状态(欠膨胀、完全膨胀、过膨胀)下的数值计算模型,研究了水下燃气喷射流对上浮水雷的受力特性影响。结果显示,欠膨胀工况时,发动机推力平缓,平均推力约为12.2kN,上浮水雷受力未出现负值;完全膨胀时,射流发生颈缩、胀鼓等现象的位置距离雷体较远,导致发动机推力及水雷壳体受力振荡不剧烈;过膨胀工况时,射流发生颈缩、胀鼓等现象的位置距离喷管较近,发动机推力发生剧烈脉动,产生21.7%的振荡幅度,胀鼓现象发生时,流场压力显著降低,使得上浮水雷后体受力减小,壳体阻力增大,上浮水雷最大产生27kN的负推力。展开更多
Background:Yuanhu Zhitong Prescription(元胡止痛方,YZP),a well-known herbal prescription for an analgesic effect,is recorded in the China Pharmacopoeia,consisting of Yanhusuo(Rhizoma Corydalis)and Baizhi(Radix Angelica...Background:Yuanhu Zhitong Prescription(元胡止痛方,YZP),a well-known herbal prescription for an analgesic effect,is recorded in the China Pharmacopoeia,consisting of Yanhusuo(Rhizoma Corydalis)and Baizhi(Radix Angelicae Dahuricae).Objective:To explore the influence of 70%EtOH extracts from Yanhusuo(Rhizoma Corydalis),Baizhi(Radix Angelicae Dahuricae)and YZP on the CYP450s,especially the differences between the single drug and prescription.Materials and methods:Cocktail probe drugs method was used to evaluate Cytochrome P450 activities in rat liver microsomes,including CYP1A2,CYP2D1,CYP2C11,CYP2C6 and CYP3A1,after rats repeatedly administrated with the extracts of Yanhusuo(Rhizoma Corydalis),Baizhi(Radix Angelicae Dahuricae)and YZP for 7 days.Results:Yanhusuo(Rhizoma Corydalis)extracts significantly increased the activities of CYP1A2,2C6 and 3A1,and inhibited that of 2D1.Baizhi(Radix Angelicae Dahuricae)extracts significantly increased the activities of CYP1A2 and inhibited that of 2D1 and 2C11.YZP extracts exhibited the same effect with single drugs.Conclusion:These results might partly interpret the TCM compatibility.Moreover,co-administration of prescriptions containing Yanhusuo(Rhizoma Corydalis),Baizhi(Radix Angelicae Dahuricae)or YZP should consider a potential herb(drug)-drug interaction medicated by the induction of CYP1A2,2C6 and 3A1 and inhibition of CYP2D1 and 2C11 enzymes.展开更多
文摘为了研究水下超声速喷射流流场压力脉动特性及其对上浮水雷的受力影响特性,基于VOF(Volume of fluid)多相流模型,建立了上浮水雷在不同工作状态(欠膨胀、完全膨胀、过膨胀)下的数值计算模型,研究了水下燃气喷射流对上浮水雷的受力特性影响。结果显示,欠膨胀工况时,发动机推力平缓,平均推力约为12.2kN,上浮水雷受力未出现负值;完全膨胀时,射流发生颈缩、胀鼓等现象的位置距离雷体较远,导致发动机推力及水雷壳体受力振荡不剧烈;过膨胀工况时,射流发生颈缩、胀鼓等现象的位置距离喷管较近,发动机推力发生剧烈脉动,产生21.7%的振荡幅度,胀鼓现象发生时,流场压力显著降低,使得上浮水雷后体受力减小,壳体阻力增大,上浮水雷最大产生27kN的负推力。
基金National Key Research and Development Program of China[2017YFC1702104,2017YFC1702303]National Natural Science Foundation of China[Grant No.81830111 and 81774201]the Youth Innovation Team of Shaanxi Universities and Shaanxi Provincial Science and Technology Department Project[No.2016SF-378]。
文摘Background:Yuanhu Zhitong Prescription(元胡止痛方,YZP),a well-known herbal prescription for an analgesic effect,is recorded in the China Pharmacopoeia,consisting of Yanhusuo(Rhizoma Corydalis)and Baizhi(Radix Angelicae Dahuricae).Objective:To explore the influence of 70%EtOH extracts from Yanhusuo(Rhizoma Corydalis),Baizhi(Radix Angelicae Dahuricae)and YZP on the CYP450s,especially the differences between the single drug and prescription.Materials and methods:Cocktail probe drugs method was used to evaluate Cytochrome P450 activities in rat liver microsomes,including CYP1A2,CYP2D1,CYP2C11,CYP2C6 and CYP3A1,after rats repeatedly administrated with the extracts of Yanhusuo(Rhizoma Corydalis),Baizhi(Radix Angelicae Dahuricae)and YZP for 7 days.Results:Yanhusuo(Rhizoma Corydalis)extracts significantly increased the activities of CYP1A2,2C6 and 3A1,and inhibited that of 2D1.Baizhi(Radix Angelicae Dahuricae)extracts significantly increased the activities of CYP1A2 and inhibited that of 2D1 and 2C11.YZP extracts exhibited the same effect with single drugs.Conclusion:These results might partly interpret the TCM compatibility.Moreover,co-administration of prescriptions containing Yanhusuo(Rhizoma Corydalis),Baizhi(Radix Angelicae Dahuricae)or YZP should consider a potential herb(drug)-drug interaction medicated by the induction of CYP1A2,2C6 and 3A1 and inhibition of CYP2D1 and 2C11 enzymes.
