细胞毒性T淋巴细胞相关抗原-4(Totoxic T lymphocyte associated antigen-4,CTLA-4)是由活化的效应T细胞(Effector T cells,Teffs)表达的膜糖蛋白,通过与CD28竞争结合其共有的B7配体,抑制T细胞增殖、活化和细胞因子产生。阻断CTLA-4与B...细胞毒性T淋巴细胞相关抗原-4(Totoxic T lymphocyte associated antigen-4,CTLA-4)是由活化的效应T细胞(Effector T cells,Teffs)表达的膜糖蛋白,通过与CD28竞争结合其共有的B7配体,抑制T细胞增殖、活化和细胞因子产生。阻断CTLA-4与B7的相互作用以增强T细胞的抗肿瘤活性,例如,靶向CTLA-4的抗体Ipilimumab和Tremelimumab广泛用于治疗多种人恶性肿瘤。在综述中,特别关注CTLA-4在免疫应答中的最新发现,并讨论了其抗体针对于非小细胞肺癌单独用药或与其他抗癌疗法相结合临床研究效果。同时发现,CTLA-4阻断治疗过程中的不良反应可能是该治疗策略发展的一大挑战。展开更多
Alcohol liver disease(ALD)has become a global threat to human health.It is associated with a wide range of liver diseases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cance...Alcohol liver disease(ALD)has become a global threat to human health.It is associated with a wide range of liver diseases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cancer and even death.Centranthera grandiflora is a traditional Chinese medicinal herb commonly used to treat ALD,but no research about its mechanism is available.This study evaluated the hepatoprotective effect and mechanism of C.grandiflora against alcohol-induced liver injury in mice.We found that the ethanol extracts of C.grandiflora(CgW)alleviated the alcohol-induced liver injury,enhanced the levels of antioxidant enzymes,and reduced the amount of lipid peroxides.CgW also affected cell apoptosis by inhibiting the activity of Bax,cleaved-caspase 3 and cleaved-caspase 9,and increasing the activity of Bcl-2.In conclusion,the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first time.This study suggested that C.grandiflora is a promising herbal medicine for ALD treatment.展开更多
Heliciopsis lobata is a medicinal plant, which is exclusively used to treat tumor in Li folk region. Two new arbutin derivatives, 6'-((E)2-methoxy-5-hydroxycinnamoyl) arbutin(1) and 2'-((E)2, 5-dihydroxycinnam...Heliciopsis lobata is a medicinal plant, which is exclusively used to treat tumor in Li folk region. Two new arbutin derivatives, 6'-((E)2-methoxy-5-hydroxycinnamoyl) arbutin(1) and 2'-((E)2, 5-dihydroxycinnamoyl) arbutin(2) along with five known compounds(3–7), were isolated from the leaves of Heliciopsis lobata. Their structures were elucidated on the basis of extensive spectroscopic interpretations. They were evaluated for their potential anticancer activity. Compounds 6 and 7 exhibited cytotoxicity against MGC-803 cells with IC_(50) values being 44.1 and 11.3 μg·m L^(–1), respectively. Additionally, compounds 1, 2 and 5–7 exhibited a moderate inhibition of MGC-803 cells invasion; compound 2 at 20 μg·m L^(–1) inhibited the invasion of MGC-803 cells by 43.0%, compared with the controls..展开更多
文摘细胞毒性T淋巴细胞相关抗原-4(Totoxic T lymphocyte associated antigen-4,CTLA-4)是由活化的效应T细胞(Effector T cells,Teffs)表达的膜糖蛋白,通过与CD28竞争结合其共有的B7配体,抑制T细胞增殖、活化和细胞因子产生。阻断CTLA-4与B7的相互作用以增强T细胞的抗肿瘤活性,例如,靶向CTLA-4的抗体Ipilimumab和Tremelimumab广泛用于治疗多种人恶性肿瘤。在综述中,特别关注CTLA-4在免疫应答中的最新发现,并讨论了其抗体针对于非小细胞肺癌单独用药或与其他抗癌疗法相结合临床研究效果。同时发现,CTLA-4阻断治疗过程中的不良反应可能是该治疗策略发展的一大挑战。
基金supported by the National Science and Technology Major Projects of New Drugs(Nos.2019ZX09301124,2019ZX09201001 and 2019ZX09301-110)the Project Program of the State Key Laboratory of Natural Medicines(No.SKLNMZZCX201821)+3 种基金the Natural Science Foundation of Jiangsu Province,China(No.BK20180569)the Open Project of State Key Laboratory of Natural Medicines(No.SKLNMKF202008)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)and the“Double First-Class”University Project(Nos.CPU2018GY13 and CPU2018PZH03)。
文摘Alcohol liver disease(ALD)has become a global threat to human health.It is associated with a wide range of liver diseases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cancer and even death.Centranthera grandiflora is a traditional Chinese medicinal herb commonly used to treat ALD,but no research about its mechanism is available.This study evaluated the hepatoprotective effect and mechanism of C.grandiflora against alcohol-induced liver injury in mice.We found that the ethanol extracts of C.grandiflora(CgW)alleviated the alcohol-induced liver injury,enhanced the levels of antioxidant enzymes,and reduced the amount of lipid peroxides.CgW also affected cell apoptosis by inhibiting the activity of Bax,cleaved-caspase 3 and cleaved-caspase 9,and increasing the activity of Bcl-2.In conclusion,the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first time.This study suggested that C.grandiflora is a promising herbal medicine for ALD treatment.
基金supported by Hainan Province modernization of Chinese medicine program,China(No.24201326)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Heliciopsis lobata is a medicinal plant, which is exclusively used to treat tumor in Li folk region. Two new arbutin derivatives, 6'-((E)2-methoxy-5-hydroxycinnamoyl) arbutin(1) and 2'-((E)2, 5-dihydroxycinnamoyl) arbutin(2) along with five known compounds(3–7), were isolated from the leaves of Heliciopsis lobata. Their structures were elucidated on the basis of extensive spectroscopic interpretations. They were evaluated for their potential anticancer activity. Compounds 6 and 7 exhibited cytotoxicity against MGC-803 cells with IC_(50) values being 44.1 and 11.3 μg·m L^(–1), respectively. Additionally, compounds 1, 2 and 5–7 exhibited a moderate inhibition of MGC-803 cells invasion; compound 2 at 20 μg·m L^(–1) inhibited the invasion of MGC-803 cells by 43.0%, compared with the controls..
