加速康复外科(enhanced recovery after surgery,ERAS)是指采用有循证医学证据的围手术期处理的一系列优化措施,以减少手术患者的生理及心理的创伤应激,达到快速康复。近年来随着医疗资源供不应求,在国家深化医疗改革的大背景下,ERAS理...加速康复外科(enhanced recovery after surgery,ERAS)是指采用有循证医学证据的围手术期处理的一系列优化措施,以减少手术患者的生理及心理的创伤应激,达到快速康复。近年来随着医疗资源供不应求,在国家深化医疗改革的大背景下,ERAS理念因其能减少患者手术创伤和应激,缩短住院时间,降低住院费用,故被国内同行所接受并在临床实践。浙江大学医学院附属邵逸夫医院自2014年6月开始,结合腔镜的优势,将ERAS理念实践于腹腔镜肝切除术患者;同时积极与国内外ERAS实践专家交流学习,包括ERAS鼻祖丹麦Kehlet教授,以及《国际肝切除ERAS专家共识》[1]的通信作者瑞士Nicolas教授。经过5年多的临床实践和积累,形成了具有可操作性的腹腔镜肝切除ERAS实践的邵医模式,也得到了同道的认可。现将我院的ERAS实践模式结合《腹腔镜肝切除术加速康复外科中国专家共识(2017版)》[2],介绍如下。展开更多
Background:The scored Patient-Generated Subjective Global Assessment(PG-SGA)has been widely used to assess the nutritional status of cancer patients.The purpose of this study is to compare the differences in PG-SGA sc...Background:The scored Patient-Generated Subjective Global Assessment(PG-SGA)has been widely used to assess the nutritional status of cancer patients.The purpose of this study is to compare the differences in PG-SGA scores and the 7 domain scores of the PG-SGA in male and female cancer patients.Methods:This study was conducted at 72 hospitals from July 2013 to December 2018,a part of the Investigation on Nutritional Status and its Clinical Outcomes of Common Cancers.The PG-SGA was recorded to evaluate the nutritional status of patients.A total of 19,528 patients with 13 common malignancies were included in this study.Student t test and the χ^(2) test were applied to analyze the sex diferences in the 7 domain scores.The Cancer Genome Atlas(TCGA)database was used to analyze the expression levels of symptom-related genes.Results:There were significant sex dfferences in the PG-SGA(P=0.032),notably in patients with gastric cancer(male vs female:9.09±4.86 vs 9.58±5.07,P=0.005)and esophageal cancer(9.64±4.90 vs 10.46±4.96,P=0.011)and the average total PG-SGA of female patients was slightly higher than that of male patients(7.64±4.98 vs 7.77±5.14).The differences were mainly related to the weight,eating,symptom,as well as activity and physical function scores in the stratified analysis.Possible causes of the sex differences were the rates of nausea,vomiting,dry mouth,and other symptoms,in both gastric and esophageal cancer patients.Analysis of the TCGA database suggested that most of the related genes were sex neutral,except for genes related to dysphagia in gastric cancer(VEGFC was higher in female patients,VEGFA and VEGFB higher in male patients).Conclusions:There are sex differences in the PG-SGA scores in patients with various tumor types(female patients generally had higher scores than male patients),with differences mainly in the weight,eating,symptom,as well as activity and physical function scores.The sex differences in PG-SGA scores might be due to the differences in the clinical manifestations of the disease,and further studies should be carried out to investigate other factors influencing the PG-SGA scores in cancer patients.This study provides basic data supporting the individualized nutritional treatment of cancer patients in clinical practice.展开更多
复方氨基酸注射液是肠外营养中氮的来源,广泛应用于不能经胃肠道给予或经胃肠道给予不能满足其营养需求的患者,在营养治疗中起重要作用。但目前对于复方氨基酸注射液临床应用的指征、剂型、剂量、时机,国内并无系统的指南或共识。为了...复方氨基酸注射液是肠外营养中氮的来源,广泛应用于不能经胃肠道给予或经胃肠道给予不能满足其营养需求的患者,在营养治疗中起重要作用。但目前对于复方氨基酸注射液临床应用的指征、剂型、剂量、时机,国内并无系统的指南或共识。为了进一步规范复方氨基酸注射液的临床应用,中华医学会肠外肠内营养学分会(Chinese Society for Parenteral and Enteral Nutrition,CSPEN)及中国抗癌协会肿瘤营养专业委员会(Chinese Society of Nutritional Oncology,CSNO)组织全国专家,在系统性文献检索的基础上,参考美国肠外肠内营养学会(American Society for Parenteral and Enteral Nutrition,ASPEN)、欧洲临床营养和代谢学会(European Society for Clinical Nutrition and Metabolism,ESPEN)、CSPEN及CSNO指南,结合我国临床实践,经多次交流讨论,达成此共识。包括10条推荐意见,涉及不同患者的蛋白质需要量及氨基酸剂型选择。展开更多
文摘加速康复外科(enhanced recovery after surgery,ERAS)是指采用有循证医学证据的围手术期处理的一系列优化措施,以减少手术患者的生理及心理的创伤应激,达到快速康复。近年来随着医疗资源供不应求,在国家深化医疗改革的大背景下,ERAS理念因其能减少患者手术创伤和应激,缩短住院时间,降低住院费用,故被国内同行所接受并在临床实践。浙江大学医学院附属邵逸夫医院自2014年6月开始,结合腔镜的优势,将ERAS理念实践于腹腔镜肝切除术患者;同时积极与国内外ERAS实践专家交流学习,包括ERAS鼻祖丹麦Kehlet教授,以及《国际肝切除ERAS专家共识》[1]的通信作者瑞士Nicolas教授。经过5年多的临床实践和积累,形成了具有可操作性的腹腔镜肝切除ERAS实践的邵医模式,也得到了同道的认可。现将我院的ERAS实践模式结合《腹腔镜肝切除术加速康复外科中国专家共识(2017版)》[2],介绍如下。
基金We are grateful for the financial support from the National Key Research and Development Program of China(2017YFC1309200).
文摘Background:The scored Patient-Generated Subjective Global Assessment(PG-SGA)has been widely used to assess the nutritional status of cancer patients.The purpose of this study is to compare the differences in PG-SGA scores and the 7 domain scores of the PG-SGA in male and female cancer patients.Methods:This study was conducted at 72 hospitals from July 2013 to December 2018,a part of the Investigation on Nutritional Status and its Clinical Outcomes of Common Cancers.The PG-SGA was recorded to evaluate the nutritional status of patients.A total of 19,528 patients with 13 common malignancies were included in this study.Student t test and the χ^(2) test were applied to analyze the sex diferences in the 7 domain scores.The Cancer Genome Atlas(TCGA)database was used to analyze the expression levels of symptom-related genes.Results:There were significant sex dfferences in the PG-SGA(P=0.032),notably in patients with gastric cancer(male vs female:9.09±4.86 vs 9.58±5.07,P=0.005)and esophageal cancer(9.64±4.90 vs 10.46±4.96,P=0.011)and the average total PG-SGA of female patients was slightly higher than that of male patients(7.64±4.98 vs 7.77±5.14).The differences were mainly related to the weight,eating,symptom,as well as activity and physical function scores in the stratified analysis.Possible causes of the sex differences were the rates of nausea,vomiting,dry mouth,and other symptoms,in both gastric and esophageal cancer patients.Analysis of the TCGA database suggested that most of the related genes were sex neutral,except for genes related to dysphagia in gastric cancer(VEGFC was higher in female patients,VEGFA and VEGFB higher in male patients).Conclusions:There are sex differences in the PG-SGA scores in patients with various tumor types(female patients generally had higher scores than male patients),with differences mainly in the weight,eating,symptom,as well as activity and physical function scores.The sex differences in PG-SGA scores might be due to the differences in the clinical manifestations of the disease,and further studies should be carried out to investigate other factors influencing the PG-SGA scores in cancer patients.This study provides basic data supporting the individualized nutritional treatment of cancer patients in clinical practice.
文摘复方氨基酸注射液是肠外营养中氮的来源,广泛应用于不能经胃肠道给予或经胃肠道给予不能满足其营养需求的患者,在营养治疗中起重要作用。但目前对于复方氨基酸注射液临床应用的指征、剂型、剂量、时机,国内并无系统的指南或共识。为了进一步规范复方氨基酸注射液的临床应用,中华医学会肠外肠内营养学分会(Chinese Society for Parenteral and Enteral Nutrition,CSPEN)及中国抗癌协会肿瘤营养专业委员会(Chinese Society of Nutritional Oncology,CSNO)组织全国专家,在系统性文献检索的基础上,参考美国肠外肠内营养学会(American Society for Parenteral and Enteral Nutrition,ASPEN)、欧洲临床营养和代谢学会(European Society for Clinical Nutrition and Metabolism,ESPEN)、CSPEN及CSNO指南,结合我国临床实践,经多次交流讨论,达成此共识。包括10条推荐意见,涉及不同患者的蛋白质需要量及氨基酸剂型选择。
