不可手术的Ⅲ期非小细胞肺癌(non-small-cell lung cancer,NSCLC)是一组异质性较强且预后较差的疾病。我国约有约有30%的NSCLC患者在初诊时即处于局部晚期。近期,GEMSTONE-301研究显示,程序性死亡受体配体-1(programmed death ligand-1,...不可手术的Ⅲ期非小细胞肺癌(non-small-cell lung cancer,NSCLC)是一组异质性较强且预后较差的疾病。我国约有约有30%的NSCLC患者在初诊时即处于局部晚期。近期,GEMSTONE-301研究显示,程序性死亡受体配体-1(programmed death ligand-1,PD-L1)单抗舒格利单抗作为巩固治疗可以改善同步或序贯放化疗后未发生疾病进展的Ⅲ期NSCLC患者的无进展生存期(progression-free survival,PFS)。该研究的结果由吴一龙教授在2021年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)大会上口头报道,并于近期刊登于《柳叶刀-肿瘤学》。本文对该项研究数据作一评述。展开更多
In view of the importance of mafic dyke swarms and their contribution to current scientific problems relating to South China,herein,we present the findings of studies on twenty–five representative mafic dykes croppin...In view of the importance of mafic dyke swarms and their contribution to current scientific problems relating to South China,herein,we present the findings of studies on twenty–five representative mafic dykes cropping out in Hunan Province and Guangxi Zhuang Autonomous Region,within the southern Wuling Mountain gravity lineament,China.These results include new zircon LA-ICP-MS U-Pb age,whole rock geochemical,Sr-Nd-Pb isotopic,and zircon Hf isotopic data for these dykes.The dykes formed between 131.5±1.2 and 121.6±1.1 Ma,and have typical doleritic textures.They fall into the alkaline and shoshonitic series,are enriched in light rare earth elements(LREE),some large ion lithophile elements(LILE;e.g.,Rb,Ba,and Sr),Th,U,and Pb,and are depleted in Nb,Ta,Hf,and Ti.Moreover,the dolerites have high initial 87 Sr/86 Sr ratios(0.7055–0.7057),negativeεNd(t)and zirconεHf(t)values(-14.8 to-11.9,-30.4 to-14.9),and relatively constant initial Pb isotopic ratios(that are EM1-like,16.77–16.94,15.43–15.47,and 36.84–36.92 for 206 Pb/204 Pb,207 Pb/204 Pb,and 208 Pb/204 Pb,respectively).These results indicate that the dykes were likely derived from magma generated through low-degree partial melting(1.0%–10%)of an EM1-like garnet–lherzolite mantle source.The parental magmas fractionated olivine,clinopyroxene,plagioclase,and Ti-bearing phases with negligible crustal contamination,during ascent and dyke emplacement.Several possible models have been proposed to explain the origin of Mesozoic magmatism along the Wuling Mountain gravity lineament.Herein we propose a reasonable model for the origin of these mafic dykes,involving the collision between the paleo-Pacific Plate and South China,which led to subsequent lithospheric extension and asthenosphere upwelling,resulting in partial melting the underlying mantle lithosphere in the Early Cretaceous,to form the parental magmas to the WMGL mafic dykes,as studied.展开更多
文摘不可手术的Ⅲ期非小细胞肺癌(non-small-cell lung cancer,NSCLC)是一组异质性较强且预后较差的疾病。我国约有约有30%的NSCLC患者在初诊时即处于局部晚期。近期,GEMSTONE-301研究显示,程序性死亡受体配体-1(programmed death ligand-1,PD-L1)单抗舒格利单抗作为巩固治疗可以改善同步或序贯放化疗后未发生疾病进展的Ⅲ期NSCLC患者的无进展生存期(progression-free survival,PFS)。该研究的结果由吴一龙教授在2021年欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)大会上口头报道,并于近期刊登于《柳叶刀-肿瘤学》。本文对该项研究数据作一评述。
基金supported by the National Natural Science Foundation of China(grant,41573022)。
文摘In view of the importance of mafic dyke swarms and their contribution to current scientific problems relating to South China,herein,we present the findings of studies on twenty–five representative mafic dykes cropping out in Hunan Province and Guangxi Zhuang Autonomous Region,within the southern Wuling Mountain gravity lineament,China.These results include new zircon LA-ICP-MS U-Pb age,whole rock geochemical,Sr-Nd-Pb isotopic,and zircon Hf isotopic data for these dykes.The dykes formed between 131.5±1.2 and 121.6±1.1 Ma,and have typical doleritic textures.They fall into the alkaline and shoshonitic series,are enriched in light rare earth elements(LREE),some large ion lithophile elements(LILE;e.g.,Rb,Ba,and Sr),Th,U,and Pb,and are depleted in Nb,Ta,Hf,and Ti.Moreover,the dolerites have high initial 87 Sr/86 Sr ratios(0.7055–0.7057),negativeεNd(t)and zirconεHf(t)values(-14.8 to-11.9,-30.4 to-14.9),and relatively constant initial Pb isotopic ratios(that are EM1-like,16.77–16.94,15.43–15.47,and 36.84–36.92 for 206 Pb/204 Pb,207 Pb/204 Pb,and 208 Pb/204 Pb,respectively).These results indicate that the dykes were likely derived from magma generated through low-degree partial melting(1.0%–10%)of an EM1-like garnet–lherzolite mantle source.The parental magmas fractionated olivine,clinopyroxene,plagioclase,and Ti-bearing phases with negligible crustal contamination,during ascent and dyke emplacement.Several possible models have been proposed to explain the origin of Mesozoic magmatism along the Wuling Mountain gravity lineament.Herein we propose a reasonable model for the origin of these mafic dykes,involving the collision between the paleo-Pacific Plate and South China,which led to subsequent lithospheric extension and asthenosphere upwelling,resulting in partial melting the underlying mantle lithosphere in the Early Cretaceous,to form the parental magmas to the WMGL mafic dykes,as studied.
