目的探讨急性脑梗死后出血转化(hemorrhagic transformation,HT)临床特征,并分析影响预后的危险因素。方法回顾性分析40例HT患者的临床特征。根据预后情况将其分为良好组22例和不良组18例,比较两组临床病例资料,分析影响预后的危险因素...目的探讨急性脑梗死后出血转化(hemorrhagic transformation,HT)临床特征,并分析影响预后的危险因素。方法回顾性分析40例HT患者的临床特征。根据预后情况将其分为良好组22例和不良组18例,比较两组临床病例资料,分析影响预后的危险因素。结果HT临床特征:HT患者中,脑叶梗死占52.50%,大面积梗死占65.00%,心源性脑栓塞型(cardioembolism,CE)占62.50%;HT发生在发病后8~14 d占57.50%;出血性梗死(hemorrhagic infarction,HI)占90.00%,脑实质内血肿(parenchyma haematoma,PH)占10.00%;HT发生后症状加重占42.50%。良好组和不良组性别、吸烟史、卒中史、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、服用抗凝药物差异有统计学意义(P<0.05)。多因素分析结果表明,NIHSS评分>12分、服用抗凝药物是影响预后的危险因素,差异有统计学意义(P<0.05)。结论脑叶梗死、大面积梗死和CE型的急性脑梗死患者更容易发生HT,HT多发于急性脑梗死后8~14 d内,多数为HI型,大部分患者不会发生症状加重。NIHSS评分>12分、服用抗凝药物是影响HT患者预后的危险因素。展开更多
目的研究低频脉冲电刺激联合药物治疗周围性面神经麻痹的疗效及对面神经功能的影响。方法采用前瞻性研究方法,选取2015年6月至2019年6月芜湖市第一人民医院收治的60例周围性面神经麻痹患者,按照随机数字表法将患者分为两组:对照组和研究...目的研究低频脉冲电刺激联合药物治疗周围性面神经麻痹的疗效及对面神经功能的影响。方法采用前瞻性研究方法,选取2015年6月至2019年6月芜湖市第一人民医院收治的60例周围性面神经麻痹患者,按照随机数字表法将患者分为两组:对照组和研究组,每组各30例。对照组患者单用药物治疗,研究组患者联用低频脉冲电刺激与药物治疗。比较两组患者治疗前后面神经麻痹程度评分、面神经功能评价量表评分(SFGS)、面神经功能指数(FNFI)、肌电图潜伏期及患健侧波幅比值以及治疗后总有效率。结果治疗后,研究组患者的面神经麻痹程度评分、眼裂闭合评分、口角偏斜评分、面神经功能指数、总有效率依次为(73.82±14.96)分、(27.03±6.29)分、(30.98±9.36)分、(0.93±0.12)、96.67%,对照组依次为(56.34±13.31)分、(49.01±7.32)分、(42.93±9.74)分、(0.80±0.14)、76.67%。对比对照组,研究组患者治疗后面神经麻痹程度评分、面神经功能指数更高,面神经功能评价量表评分(27.03±6.29分vs.49.01±7.32分、30.98±9.36分vs.42.93±9.74分)与口轮匝肌(2.98±0.38 ms vs.3.29±0.41 ms)、鼻肌(2.82±0.38 ms vs.3.12±0.40 ms)、眼轮匝肌(3.08±0.48 ms vs.3.69±0.47 ms)的神经肌电图潜伏期更低,而患健侧波幅比值更高(P<0.05)。结论低频脉冲电刺激联合药物治疗周围性面神经麻痹具有显著疗效,可有效减轻患者面神经麻痹程度,促使其面神经功能快速恢复,并改善肌电图。展开更多
Flavonoids have been reported to exert protective effect against many inflammatory diseases, while the underlying cellular mechanisms are still not completely known. In the present study, we explored the anti-inflamma...Flavonoids have been reported to exert protective effect against many inflammatory diseases, while the underlying cellular mechanisms are still not completely known. In the present study, we explored the anti-inflammation activity of 5, 7, 2', 4', 5'-pentamethoxyflavanone(abbreviated as Pen.), a kind of polymethoxylated flavonoid, both in vitro and in vivo experiments. Pen. was showed no obvious toxicity in macrophages even at high dosage treatment. Our results indicated that Pen. significantly inhibited both mR NA and protein level of proinflammatory cytokines, IL-1β, IL-6, TNF-α and iN OS, which was characteristic expressed on M1 polarized macrophages. These effects of Pen. were further confirmed by diminished expression of CD11c, the M1 macrophage surface marker. Further researches showed that the mechanism was due to that Pen. downregulated the activity of p65, key transcription factor for M1 polarization. On the other hand, Pen. also enhanced M2 polarization with upregulation of anti-inflammatory factors and increase of M2 macrophage surface markers, which lead to the balance of M1 and M2 macrophages. Moreover, in vivo research verified that Pen. treatment alleviated LPS-induced sepsis in mice by increasing survival rate, decreasing inflammatory cytokines and improving lung tissue damage. In summary, our results suggested that Pen. modulated macrophage phenotype via suppressing p65 signal pathway to exert the anti-inflammation activity.展开更多
文摘目的探讨急性脑梗死后出血转化(hemorrhagic transformation,HT)临床特征,并分析影响预后的危险因素。方法回顾性分析40例HT患者的临床特征。根据预后情况将其分为良好组22例和不良组18例,比较两组临床病例资料,分析影响预后的危险因素。结果HT临床特征:HT患者中,脑叶梗死占52.50%,大面积梗死占65.00%,心源性脑栓塞型(cardioembolism,CE)占62.50%;HT发生在发病后8~14 d占57.50%;出血性梗死(hemorrhagic infarction,HI)占90.00%,脑实质内血肿(parenchyma haematoma,PH)占10.00%;HT发生后症状加重占42.50%。良好组和不良组性别、吸烟史、卒中史、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、服用抗凝药物差异有统计学意义(P<0.05)。多因素分析结果表明,NIHSS评分>12分、服用抗凝药物是影响预后的危险因素,差异有统计学意义(P<0.05)。结论脑叶梗死、大面积梗死和CE型的急性脑梗死患者更容易发生HT,HT多发于急性脑梗死后8~14 d内,多数为HI型,大部分患者不会发生症状加重。NIHSS评分>12分、服用抗凝药物是影响HT患者预后的危险因素。
文摘目的研究低频脉冲电刺激联合药物治疗周围性面神经麻痹的疗效及对面神经功能的影响。方法采用前瞻性研究方法,选取2015年6月至2019年6月芜湖市第一人民医院收治的60例周围性面神经麻痹患者,按照随机数字表法将患者分为两组:对照组和研究组,每组各30例。对照组患者单用药物治疗,研究组患者联用低频脉冲电刺激与药物治疗。比较两组患者治疗前后面神经麻痹程度评分、面神经功能评价量表评分(SFGS)、面神经功能指数(FNFI)、肌电图潜伏期及患健侧波幅比值以及治疗后总有效率。结果治疗后,研究组患者的面神经麻痹程度评分、眼裂闭合评分、口角偏斜评分、面神经功能指数、总有效率依次为(73.82±14.96)分、(27.03±6.29)分、(30.98±9.36)分、(0.93±0.12)、96.67%,对照组依次为(56.34±13.31)分、(49.01±7.32)分、(42.93±9.74)分、(0.80±0.14)、76.67%。对比对照组,研究组患者治疗后面神经麻痹程度评分、面神经功能指数更高,面神经功能评价量表评分(27.03±6.29分vs.49.01±7.32分、30.98±9.36分vs.42.93±9.74分)与口轮匝肌(2.98±0.38 ms vs.3.29±0.41 ms)、鼻肌(2.82±0.38 ms vs.3.12±0.40 ms)、眼轮匝肌(3.08±0.48 ms vs.3.69±0.47 ms)的神经肌电图潜伏期更低,而患健侧波幅比值更高(P<0.05)。结论低频脉冲电刺激联合药物治疗周围性面神经麻痹具有显著疗效,可有效减轻患者面神经麻痹程度,促使其面神经功能快速恢复,并改善肌电图。
基金supported by the National Natural Science Foundation of China(Nos.81872916,81673487,and 81473221)"The Drug Innovation Major Project" of National Science & Technology Ministry(No.2018ZX09711001-003-007)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20161399)the Fundamental Research Funds for the Central Universities(No.020814380118)
文摘Flavonoids have been reported to exert protective effect against many inflammatory diseases, while the underlying cellular mechanisms are still not completely known. In the present study, we explored the anti-inflammation activity of 5, 7, 2', 4', 5'-pentamethoxyflavanone(abbreviated as Pen.), a kind of polymethoxylated flavonoid, both in vitro and in vivo experiments. Pen. was showed no obvious toxicity in macrophages even at high dosage treatment. Our results indicated that Pen. significantly inhibited both mR NA and protein level of proinflammatory cytokines, IL-1β, IL-6, TNF-α and iN OS, which was characteristic expressed on M1 polarized macrophages. These effects of Pen. were further confirmed by diminished expression of CD11c, the M1 macrophage surface marker. Further researches showed that the mechanism was due to that Pen. downregulated the activity of p65, key transcription factor for M1 polarization. On the other hand, Pen. also enhanced M2 polarization with upregulation of anti-inflammatory factors and increase of M2 macrophage surface markers, which lead to the balance of M1 and M2 macrophages. Moreover, in vivo research verified that Pen. treatment alleviated LPS-induced sepsis in mice by increasing survival rate, decreasing inflammatory cytokines and improving lung tissue damage. In summary, our results suggested that Pen. modulated macrophage phenotype via suppressing p65 signal pathway to exert the anti-inflammation activity.
