Objective:To observe the clinical efcacy and safety of external application of Rupi Sanjie Xiaotong Plaster(乳癖散结消痛膏,RPSJXTP)in treating breast hyperplasia of liver stagnation and phlegm coagulation pattern.Meth...Objective:To observe the clinical efcacy and safety of external application of Rupi Sanjie Xiaotong Plaster(乳癖散结消痛膏,RPSJXTP)in treating breast hyperplasia of liver stagnation and phlegm coagulation pattern.Methods:Totally 72 female patients with breast hyperplasia of liver stagnation and phlegm coagulation pattern admitted to the First Hospital Affiliated to Henan University of Chinese Medicine were enrolled by ran-domized,single-blind,placebo-controlled research method,and were divided into the treatment group(36 ca-ses)and the control group(36 cases)according to computer random number method.The treatment group were given RPSJXTP,while the control group were gi ven placebo plaster.The course of treatment in both groups was 8 weeks.The breast pain score,breast color ultrasound score,lump score,depression score,and Chinese medicine syndrome score were compared between the two groups at different times.The levels of estra-diol(E_(2)),progesterone(P)and pituitary prolactin(PRL)were detected and the adverse reactions of two groups were observed during the treatment of both groups.Results:Before treatment,there was no significant difference in total breast pain score,breast color ultrasound score,lump score,depression score and levels of serum P,E_(2)and PRL between the two groups(P>0.05);compared with previous treatment,the total breast pain score,breast color ultrasound score,lump score,and depression score significantly decreased in the treat-ment group(P<0.05),and the total breast pain score and depression score of the control group significantly declined(P<0.05);compared with control group,the total breast pain score,breast color ultrasound score,lump score,and depression score significantly decreased after treatment in the treatment group(P<0.05).The improvement rate of Chinese medicine syndromes and the clinical efective rate in the treatment group were higher than those in the control group(P<0.05).There were no serious systemie adverse reactions during the treatment in both groups.Local pruritus occurred in 3 cases in the treatment group and 1 case in the control group.Conclusion:RPSJXTP is effective in treating breast hyperplasia of liver stagnation and phlegm coagula-tion pattern.It can effectively relieve the breast pain which will not recur after stopping of drug use,which can reduce the color ultrasound score,lump score,and depression score of the patients and improve Chinese medi-cine syndromes without serious adverse reactions.展开更多
目的总结急性呼吸道传染病患者经鼻高流量氧疗期间医院感染防控的最佳证据。方法制订文献检索策略,检索BMJ best practice、UpToDate、美国国立指南库、英国国家卫生与临床优化研究所网站、苏格兰院际指南网、世界卫生组织网、美国呼吸...目的总结急性呼吸道传染病患者经鼻高流量氧疗期间医院感染防控的最佳证据。方法制订文献检索策略,检索BMJ best practice、UpToDate、美国国立指南库、英国国家卫生与临床优化研究所网站、苏格兰院际指南网、世界卫生组织网、美国呼吸治疗协会网、欧洲呼吸学会网、医脉通数据库、Cochrane Library、PubMed、CINAHL、Web of Science、万方数据库、中国知网,检索时限为建库至2022年8月。根据筛选标准选取与本研究相关的文献,进行文献质量评价后提取证据。结果共纳入11篇文献,包括9篇专家共识、1篇系统评价和1篇原始研究,提取26条证据,包括人员管理、环境管理、医护人员防护、医疗护理操作、终末处理、急救管理6个类别。结论该研究总结的最佳证据对急性呼吸道传染病患者经鼻高流量氧疗期间的医院感染预防与控制具有指导意义,证据应用时需结合病原体特性、传播性等进行综合评判。展开更多
文摘Objective:To observe the clinical efcacy and safety of external application of Rupi Sanjie Xiaotong Plaster(乳癖散结消痛膏,RPSJXTP)in treating breast hyperplasia of liver stagnation and phlegm coagulation pattern.Methods:Totally 72 female patients with breast hyperplasia of liver stagnation and phlegm coagulation pattern admitted to the First Hospital Affiliated to Henan University of Chinese Medicine were enrolled by ran-domized,single-blind,placebo-controlled research method,and were divided into the treatment group(36 ca-ses)and the control group(36 cases)according to computer random number method.The treatment group were given RPSJXTP,while the control group were gi ven placebo plaster.The course of treatment in both groups was 8 weeks.The breast pain score,breast color ultrasound score,lump score,depression score,and Chinese medicine syndrome score were compared between the two groups at different times.The levels of estra-diol(E_(2)),progesterone(P)and pituitary prolactin(PRL)were detected and the adverse reactions of two groups were observed during the treatment of both groups.Results:Before treatment,there was no significant difference in total breast pain score,breast color ultrasound score,lump score,depression score and levels of serum P,E_(2)and PRL between the two groups(P>0.05);compared with previous treatment,the total breast pain score,breast color ultrasound score,lump score,and depression score significantly decreased in the treat-ment group(P<0.05),and the total breast pain score and depression score of the control group significantly declined(P<0.05);compared with control group,the total breast pain score,breast color ultrasound score,lump score,and depression score significantly decreased after treatment in the treatment group(P<0.05).The improvement rate of Chinese medicine syndromes and the clinical efective rate in the treatment group were higher than those in the control group(P<0.05).There were no serious systemie adverse reactions during the treatment in both groups.Local pruritus occurred in 3 cases in the treatment group and 1 case in the control group.Conclusion:RPSJXTP is effective in treating breast hyperplasia of liver stagnation and phlegm coagula-tion pattern.It can effectively relieve the breast pain which will not recur after stopping of drug use,which can reduce the color ultrasound score,lump score,and depression score of the patients and improve Chinese medi-cine syndromes without serious adverse reactions.
文摘目的总结急性呼吸道传染病患者经鼻高流量氧疗期间医院感染防控的最佳证据。方法制订文献检索策略,检索BMJ best practice、UpToDate、美国国立指南库、英国国家卫生与临床优化研究所网站、苏格兰院际指南网、世界卫生组织网、美国呼吸治疗协会网、欧洲呼吸学会网、医脉通数据库、Cochrane Library、PubMed、CINAHL、Web of Science、万方数据库、中国知网,检索时限为建库至2022年8月。根据筛选标准选取与本研究相关的文献,进行文献质量评价后提取证据。结果共纳入11篇文献,包括9篇专家共识、1篇系统评价和1篇原始研究,提取26条证据,包括人员管理、环境管理、医护人员防护、医疗护理操作、终末处理、急救管理6个类别。结论该研究总结的最佳证据对急性呼吸道传染病患者经鼻高流量氧疗期间的医院感染预防与控制具有指导意义,证据应用时需结合病原体特性、传播性等进行综合评判。
