目的系统评价泊沙康唑预防侵袭性真菌感染的疗效及安全性。方法检索PubMed、Web of Science、Embase、Cochrane Library、Clinicaltrials.gov、中国知网期刊全文数据库、维普中文科技期刊数据库、万方数据库及中国生物医学文献数据库,...目的系统评价泊沙康唑预防侵袭性真菌感染的疗效及安全性。方法检索PubMed、Web of Science、Embase、Cochrane Library、Clinicaltrials.gov、中国知网期刊全文数据库、维普中文科技期刊数据库、万方数据库及中国生物医学文献数据库,截止时间2019年9月20日,收集所有关于泊沙康唑与其他抗真菌药预防侵袭性真菌感染疗效及安全性的对比研究,采用RevMan 5.2软件进行Meta分析。结果共纳入符合标准的文献13篇。Meta分析结果显示,泊沙康唑预防疗效优于氟康唑(RR=0.41,95%CI:0.27~0.62,P<0.0001)和伊曲康唑(RR=0.21,95%CI:0.09~0.54,P=0.001),但与伏立康唑(RR=0.34,95%CI:0.05~2.11,P=0.24)、两性霉素B脂质复合物(RR=0.30,95%CI:0.01~7.02,P=0.46)及米卡芬净(RR=0.44,95%CI:0.19~1.02,P=0.06)预防疗效相当。泊沙康唑全因死亡率(RR=0.80,95%CI:0.66~0.97,P=0.02)和证实或很可能是侵袭性真菌感染引起的死亡率(RR=0.35,95%CI:0.18~0.67,P=0.002]均低于其他抗真菌药,且未增加不良反应的发生率,甚至比伏立康唑(RR=0.36,95%CI:0.20~0.67,P=0.001)的不良反应发生率更低。结论泊沙康唑预防侵袭性真菌感染具有良好的疗效和安全性,能降低患者的全因死亡率和侵袭性真菌感染相关死亡率。展开更多
The Allan variance analysis method is used to identify the stochastic noise in the stray current sensor. The stray current characteristic is firstly introduced. Then the optical configuration and the signal processing...The Allan variance analysis method is used to identify the stochastic noise in the stray current sensor. The stray current characteristic is firstly introduced. Then the optical configuration and the signal processing method of the stray current sensor are illustrated. Moreover, the cause of the stochastic noise in the stray current sensor is analyzed. The calculation method of the stochastic noise coefficient is presented in detail. And the feasibility of the stochastic noise identification with the Allan variance analysis method is evaluated. Furthermore, the zero-drift signal acquisition experiment is conducted to identify the stochastic noise in the stray current sensor. According to the experimental result, the bias instability noise, the quantization noise and the white noise are identified as the major stochastic noise. Finally, the experiment on the direct-current signal acquisitions is conducted, whose results indicate that the signal drift of the measured direct-current is mainly caused by the major stochastic noise. And the suppression methods of the major stochastic noise are proposed.展开更多
目的 分析福州市2021年不同性取向男男性行为(men who have sex with men, MSM)人群在艾滋病病毒(Human immunodeficiency virus,HIV)传播中的作用和意义。方法 2021年1-12月,通过门诊、网络、相关场所干预等方式招募MSM人群。开展横断...目的 分析福州市2021年不同性取向男男性行为(men who have sex with men, MSM)人群在艾滋病病毒(Human immunodeficiency virus,HIV)传播中的作用和意义。方法 2021年1-12月,通过门诊、网络、相关场所干预等方式招募MSM人群。开展横断面调查,采用金数据和SPSS 25.0软件整理数据并分析。结果 调查MSM人群2 247人,同性性取向MSM 1 808人,构成比为80.46%,双性性取向439人,构成比为19.54%,艾滋病感染率为4.94%。同性和双性性取向MSM在年龄、婚姻状况、学历、艾滋病知晓率差异有统计学意义(χ^(2)=176.740、351.369、42.948、43.896,P均<0.001);同性性取向MSM在是否通过互联网寻找性伴、最近6个月同性肛交行为、最近6个月肛交安全套使用频率高于双性性取向MSM,差异有统计学意义(χ^(2)=40.870、140.806、10.662,P均<0.001);双性性取向MSM在最近一次肛交行为是否使用安全套、最近6个月是否发生异性性行为高于同性性取向MSM,差异有统计学意义(χ^(2)=8.731、454.465,P均<0.001)。结论 福州市2021年同性和双性性取向MSM的行为特点不同,应根据人群行为特征采取针对性的干预策略。展开更多
文摘目的系统评价泊沙康唑预防侵袭性真菌感染的疗效及安全性。方法检索PubMed、Web of Science、Embase、Cochrane Library、Clinicaltrials.gov、中国知网期刊全文数据库、维普中文科技期刊数据库、万方数据库及中国生物医学文献数据库,截止时间2019年9月20日,收集所有关于泊沙康唑与其他抗真菌药预防侵袭性真菌感染疗效及安全性的对比研究,采用RevMan 5.2软件进行Meta分析。结果共纳入符合标准的文献13篇。Meta分析结果显示,泊沙康唑预防疗效优于氟康唑(RR=0.41,95%CI:0.27~0.62,P<0.0001)和伊曲康唑(RR=0.21,95%CI:0.09~0.54,P=0.001),但与伏立康唑(RR=0.34,95%CI:0.05~2.11,P=0.24)、两性霉素B脂质复合物(RR=0.30,95%CI:0.01~7.02,P=0.46)及米卡芬净(RR=0.44,95%CI:0.19~1.02,P=0.06)预防疗效相当。泊沙康唑全因死亡率(RR=0.80,95%CI:0.66~0.97,P=0.02)和证实或很可能是侵袭性真菌感染引起的死亡率(RR=0.35,95%CI:0.18~0.67,P=0.002]均低于其他抗真菌药,且未增加不良反应的发生率,甚至比伏立康唑(RR=0.36,95%CI:0.20~0.67,P=0.001)的不良反应发生率更低。结论泊沙康唑预防侵袭性真菌感染具有良好的疗效和安全性,能降低患者的全因死亡率和侵袭性真菌感染相关死亡率。
基金Project(2017QNA13)supported by Fundamental Research Funds for the Central Universities,ChinaProject(PAPD)supported by Priority Academic Program Development of Jiangsu Higher Education Institutions,China
文摘The Allan variance analysis method is used to identify the stochastic noise in the stray current sensor. The stray current characteristic is firstly introduced. Then the optical configuration and the signal processing method of the stray current sensor are illustrated. Moreover, the cause of the stochastic noise in the stray current sensor is analyzed. The calculation method of the stochastic noise coefficient is presented in detail. And the feasibility of the stochastic noise identification with the Allan variance analysis method is evaluated. Furthermore, the zero-drift signal acquisition experiment is conducted to identify the stochastic noise in the stray current sensor. According to the experimental result, the bias instability noise, the quantization noise and the white noise are identified as the major stochastic noise. Finally, the experiment on the direct-current signal acquisitions is conducted, whose results indicate that the signal drift of the measured direct-current is mainly caused by the major stochastic noise. And the suppression methods of the major stochastic noise are proposed.
文摘目的 分析福州市2021年不同性取向男男性行为(men who have sex with men, MSM)人群在艾滋病病毒(Human immunodeficiency virus,HIV)传播中的作用和意义。方法 2021年1-12月,通过门诊、网络、相关场所干预等方式招募MSM人群。开展横断面调查,采用金数据和SPSS 25.0软件整理数据并分析。结果 调查MSM人群2 247人,同性性取向MSM 1 808人,构成比为80.46%,双性性取向439人,构成比为19.54%,艾滋病感染率为4.94%。同性和双性性取向MSM在年龄、婚姻状况、学历、艾滋病知晓率差异有统计学意义(χ^(2)=176.740、351.369、42.948、43.896,P均<0.001);同性性取向MSM在是否通过互联网寻找性伴、最近6个月同性肛交行为、最近6个月肛交安全套使用频率高于双性性取向MSM,差异有统计学意义(χ^(2)=40.870、140.806、10.662,P均<0.001);双性性取向MSM在最近一次肛交行为是否使用安全套、最近6个月是否发生异性性行为高于同性性取向MSM,差异有统计学意义(χ^(2)=8.731、454.465,P均<0.001)。结论 福州市2021年同性和双性性取向MSM的行为特点不同,应根据人群行为特征采取针对性的干预策略。
