目的探讨艾司氯胺酮无阿片全身麻醉对老年全髋关节置换术(THR)患者神经源炎性因子、脑氧代谢、麻醉及苏醒质量的影响。方法选取2022年4月—2023年4月择期行THR的老年患者86例,随机将其分为观察组和对照组2组各43例。观察组行艾司氯胺酮...目的探讨艾司氯胺酮无阿片全身麻醉对老年全髋关节置换术(THR)患者神经源炎性因子、脑氧代谢、麻醉及苏醒质量的影响。方法选取2022年4月—2023年4月择期行THR的老年患者86例,随机将其分为观察组和对照组2组各43例。观察组行艾司氯胺酮无阿片麻醉,对照组行常规麻醉。比较2组麻醉诱导前、气管插管时(T2)、切皮时(T3)、拔出气管导管时(T4)血流动力学[平均动脉压(MAP)和心率(HR)]、神经源炎性因子[神经生长因子(NGF)、前列腺素E_(2)(PGE_(2))、P物质和神经激肽A(NKA)]、脑保护作用指标[脑氧摄取率(CERO_(2))、动脉-颈内静脉球部血氧差(Da-jvO_(2))、神经元特异性烯醇化酶(NSE)和S-100β蛋白],术后第1、2、3天疼痛视觉模拟评分法(VAS)、术后恶心呕吐(PONV)评分,术前和术后第1、3、7天简明精神状态量表(MMSE)评分,苏醒质量,以及术中、术后不良反应。结果T2~T4时,2组MAP和HR均呈现升高趋势,NGF、PGE_(2)、SP、NKA、CERO_(2)、Da-jvO_(2)、NSE和S-100β蛋白均呈现降低趋势;且观察组MAP和HR均高于对照组,NGF、PGE_(2)、SP、NKA、CERO_(2)、Da-jvO_(2)、NSE和S-100β蛋白均低于对照组(P<0.05)。术后第1、2及3天,2组VAS和PONV评分均呈下降趋势,术后第1、3及7天MMSE评分均呈升高趋势;且观察组术后第1、2及3天VAS和PONV评分低于对照组,术后第1、3及7天MMSE评分高于对照组(P<0.05)。观察组拔管时间和苏醒时间均短于对照组,拔管后10 min Ramsay评分低于对照组(P<0.05)。术中和术后,观察组不良反应发生率为11.63%(5/43)低于对照组37.21%(16/43)(P<0.05)。结论艾司氯胺酮无阿片全身麻醉用于老年THR患者有利于稳定血流动力学,提高术后苏醒质量,缓解疼痛感,且能改善脑氧代谢,降低不良反应发生率,分析可能与其调节神经源炎症反应有关。展开更多
On the basis of the new-new trade theory, this paper makes use of the micro-level export data of China's international trade with sixteen major trading partners from CEPII BACI international trade database of1996-...On the basis of the new-new trade theory, this paper makes use of the micro-level export data of China's international trade with sixteen major trading partners from CEPII BACI international trade database of1996-2011 and decomposes the total export growth into the intensive margin and expansion margin, so as to conduct an empirical analysis of the impact of trade promotion agency on China's export binary marginal growth with the GMM dynamic panel data model estimation method. The results show that trade promotion agency has a significant positive impact on the intensive margin and expansion margin of export growth,the promoting effect on the export growth expansion margin is greater than that on the intensive margin.The trade promotion committees can play more significant role in promoting export than embassies and consulates stationed abroad. The promoting effect of trade promotion agencies on export growth binary margin of medium and high-tech industry products is larger than that on the medium and lower technology industry products. Therefore, China should increase the number of trade promotion agencies, in particular,have more Trade Promotion Committees.展开更多
On the basis of measuring the bilateral trade costs between China and 86 trade partners and the aggregate trade costs from 2000 to 2013,this paper takes China’s vertical specialization reality into account,to do an e...On the basis of measuring the bilateral trade costs between China and 86 trade partners and the aggregate trade costs from 2000 to 2013,this paper takes China’s vertical specialization reality into account,to do an empirical study on the impact of China’s aggregate trade costs on comparative advantages and export share of 17 two-digit ISIC manufacturing industries,and to conduct these types of robust tests in order to eliminate endogeneity bias.The results show that China’s aggregate trade costs are declining,but it is still 1/3 higher than that of developed countries of 10 years ago;bilateral trade costs between China and some countries even rise instead;aggregate trade costs are the determinants,not only of‘global’and‘local’comparative advantages,but also of export share of China’s manufacturing products,and its effect is stronger in industries with higher trade cost intensity.Therefore,we should consider the product composition on trade cost intensity and domestic value-added value(DVAR),and reduce trade costs in order to promote the export of products with higher domestic value-added rate,and to realize the substantial transformation of foreign trade growth mode.展开更多
目的:观察双合汤联合微创保髋术治疗围塌陷期酒精性股骨头坏死(Alcohol-induced Osteonecrosis of the Femoral Head,AOFH)的临床疗效。方法:84例AOFH患者随机分成对照组与观察组,每组各42例。对照组给予微创保髋术+仙灵骨葆,观察组给...目的:观察双合汤联合微创保髋术治疗围塌陷期酒精性股骨头坏死(Alcohol-induced Osteonecrosis of the Femoral Head,AOFH)的临床疗效。方法:84例AOFH患者随机分成对照组与观察组,每组各42例。对照组给予微创保髋术+仙灵骨葆,观察组给予微创保髋术+双合汤,疗程均为6个月。分别观察两组JOA评分、FPS-R评分、股骨头坏死(ONFH)指数;检测血脂[总胆固醇(TC)、甘油三酯(TG)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)]水平,凝血指标[凝血酶时间(TT)、凝血酶原时间(PT)、P选择素、血栓调节蛋白(TM)含量],骨代谢指标[骨特异性碱性磷酸酶(BALP)、Ⅰ型前胶原氨基端前肽(PⅠNP)、转化生长因子-β1(TGF-β1)、骨保护素(OPG)]含量,生化标记物[癌胚抗原相关细胞黏附分子1(CEACAM1)、瘦素、神经肽(Nesfatin-1)]含量;比较两组中医证侯疗效、不良反应情况。结果:观察组总优良率为80.95%(34/42),高于对照组的52.38%(22/42)(χ^(2)=5.093,P<0.05);观察组术后6月、12月时,JOA评分、FPS-R评分、ONFH坏死指数优于对照组(P<0.05);与本组治疗前比较,两组术后6月、12月时,TC、TG、ApoA、ApoB、P选择素、TM、PINP、瘦素、Nesfatin-1含量明显降低(P<0.05),TT、PT时间、BALP活力、TGF-β1、OPG、CEACAM1含量明显升高(P<0.05);术后6月、12月时与对照组比较,观察组TC、TG、ApoA、ApoB、P选择素、TM、PINP、瘦素、Nesfatin-1含量明显降低(P<0.05),TT、PT时间、BALP活力、TGF-β1、OPG、CEACAM1含量明显升高(P<0.05);两组治疗期间未见明显不良反应。结论:双合汤联合微创保髋术治疗围塌陷期AOFH临床疗效良好,可明显改善患者临床症状,降低血液黏度,改善骨代谢指标和生化标记物水平。展开更多
文摘目的探讨艾司氯胺酮无阿片全身麻醉对老年全髋关节置换术(THR)患者神经源炎性因子、脑氧代谢、麻醉及苏醒质量的影响。方法选取2022年4月—2023年4月择期行THR的老年患者86例,随机将其分为观察组和对照组2组各43例。观察组行艾司氯胺酮无阿片麻醉,对照组行常规麻醉。比较2组麻醉诱导前、气管插管时(T2)、切皮时(T3)、拔出气管导管时(T4)血流动力学[平均动脉压(MAP)和心率(HR)]、神经源炎性因子[神经生长因子(NGF)、前列腺素E_(2)(PGE_(2))、P物质和神经激肽A(NKA)]、脑保护作用指标[脑氧摄取率(CERO_(2))、动脉-颈内静脉球部血氧差(Da-jvO_(2))、神经元特异性烯醇化酶(NSE)和S-100β蛋白],术后第1、2、3天疼痛视觉模拟评分法(VAS)、术后恶心呕吐(PONV)评分,术前和术后第1、3、7天简明精神状态量表(MMSE)评分,苏醒质量,以及术中、术后不良反应。结果T2~T4时,2组MAP和HR均呈现升高趋势,NGF、PGE_(2)、SP、NKA、CERO_(2)、Da-jvO_(2)、NSE和S-100β蛋白均呈现降低趋势;且观察组MAP和HR均高于对照组,NGF、PGE_(2)、SP、NKA、CERO_(2)、Da-jvO_(2)、NSE和S-100β蛋白均低于对照组(P<0.05)。术后第1、2及3天,2组VAS和PONV评分均呈下降趋势,术后第1、3及7天MMSE评分均呈升高趋势;且观察组术后第1、2及3天VAS和PONV评分低于对照组,术后第1、3及7天MMSE评分高于对照组(P<0.05)。观察组拔管时间和苏醒时间均短于对照组,拔管后10 min Ramsay评分低于对照组(P<0.05)。术中和术后,观察组不良反应发生率为11.63%(5/43)低于对照组37.21%(16/43)(P<0.05)。结论艾司氯胺酮无阿片全身麻醉用于老年THR患者有利于稳定血流动力学,提高术后苏醒质量,缓解疼痛感,且能改善脑氧代谢,降低不良反应发生率,分析可能与其调节神经源炎症反应有关。
文摘On the basis of the new-new trade theory, this paper makes use of the micro-level export data of China's international trade with sixteen major trading partners from CEPII BACI international trade database of1996-2011 and decomposes the total export growth into the intensive margin and expansion margin, so as to conduct an empirical analysis of the impact of trade promotion agency on China's export binary marginal growth with the GMM dynamic panel data model estimation method. The results show that trade promotion agency has a significant positive impact on the intensive margin and expansion margin of export growth,the promoting effect on the export growth expansion margin is greater than that on the intensive margin.The trade promotion committees can play more significant role in promoting export than embassies and consulates stationed abroad. The promoting effect of trade promotion agencies on export growth binary margin of medium and high-tech industry products is larger than that on the medium and lower technology industry products. Therefore, China should increase the number of trade promotion agencies, in particular,have more Trade Promotion Committees.
文摘On the basis of measuring the bilateral trade costs between China and 86 trade partners and the aggregate trade costs from 2000 to 2013,this paper takes China’s vertical specialization reality into account,to do an empirical study on the impact of China’s aggregate trade costs on comparative advantages and export share of 17 two-digit ISIC manufacturing industries,and to conduct these types of robust tests in order to eliminate endogeneity bias.The results show that China’s aggregate trade costs are declining,but it is still 1/3 higher than that of developed countries of 10 years ago;bilateral trade costs between China and some countries even rise instead;aggregate trade costs are the determinants,not only of‘global’and‘local’comparative advantages,but also of export share of China’s manufacturing products,and its effect is stronger in industries with higher trade cost intensity.Therefore,we should consider the product composition on trade cost intensity and domestic value-added value(DVAR),and reduce trade costs in order to promote the export of products with higher domestic value-added rate,and to realize the substantial transformation of foreign trade growth mode.
文摘目的:观察双合汤联合微创保髋术治疗围塌陷期酒精性股骨头坏死(Alcohol-induced Osteonecrosis of the Femoral Head,AOFH)的临床疗效。方法:84例AOFH患者随机分成对照组与观察组,每组各42例。对照组给予微创保髋术+仙灵骨葆,观察组给予微创保髋术+双合汤,疗程均为6个月。分别观察两组JOA评分、FPS-R评分、股骨头坏死(ONFH)指数;检测血脂[总胆固醇(TC)、甘油三酯(TG)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)]水平,凝血指标[凝血酶时间(TT)、凝血酶原时间(PT)、P选择素、血栓调节蛋白(TM)含量],骨代谢指标[骨特异性碱性磷酸酶(BALP)、Ⅰ型前胶原氨基端前肽(PⅠNP)、转化生长因子-β1(TGF-β1)、骨保护素(OPG)]含量,生化标记物[癌胚抗原相关细胞黏附分子1(CEACAM1)、瘦素、神经肽(Nesfatin-1)]含量;比较两组中医证侯疗效、不良反应情况。结果:观察组总优良率为80.95%(34/42),高于对照组的52.38%(22/42)(χ^(2)=5.093,P<0.05);观察组术后6月、12月时,JOA评分、FPS-R评分、ONFH坏死指数优于对照组(P<0.05);与本组治疗前比较,两组术后6月、12月时,TC、TG、ApoA、ApoB、P选择素、TM、PINP、瘦素、Nesfatin-1含量明显降低(P<0.05),TT、PT时间、BALP活力、TGF-β1、OPG、CEACAM1含量明显升高(P<0.05);术后6月、12月时与对照组比较,观察组TC、TG、ApoA、ApoB、P选择素、TM、PINP、瘦素、Nesfatin-1含量明显降低(P<0.05),TT、PT时间、BALP活力、TGF-β1、OPG、CEACAM1含量明显升高(P<0.05);两组治疗期间未见明显不良反应。结论:双合汤联合微创保髋术治疗围塌陷期AOFH临床疗效良好,可明显改善患者临床症状,降低血液黏度,改善骨代谢指标和生化标记物水平。
