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异基因造血干细胞移植治疗急性髓系白血病的临床分析 被引量:9
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作者 王清云 董玉君 +7 位作者 梁赜隐 尹玥 刘微 许蔚林 孙玉华 韩娜 李渊 任汉云 《中国实验血液学杂志》 CAS CSCD 北大核心 2020年第4期1105-1114,共10页
目的:分析异基因造血干细胞移植(allo-HSCT)治疗急性髓系白血病(AML)患者的生存与复发危险因素,并探讨AML复发后的治疗选择。方法:对2009年1月至2018年12月于本中心行allo-HSCT术后处于完全缓解(CR)期的180例AML患者进行回顾性分析,应用... 目的:分析异基因造血干细胞移植(allo-HSCT)治疗急性髓系白血病(AML)患者的生存与复发危险因素,并探讨AML复发后的治疗选择。方法:对2009年1月至2018年12月于本中心行allo-HSCT术后处于完全缓解(CR)期的180例AML患者进行回顾性分析,应用COX比例风险模型进行单因素和多因素分析,探讨影响移植后生存及复发的危险因素。结果:180例患者中,134例(74.4%)存活,46例(25.6%)死亡,40例(22.2%)复发。移植后5年总生存(OS)率、无事件生存(EFS)率、累积复发率分别为74.3%、42.5%和25.0%。AML危险分层为高危组、伴高危细胞遗传学、移植前为CR2期以及未发生慢性移植物抗宿主病(cGVHD)是影响移植后OS的独立危险因素;移植前为CR2期、AML危险分层高危组是影响移植后EFS的独立危险因素;AML危险分层高危组、单疗程诱导治疗后微小残留病MRD+、伴高危细胞遗传学、未发生cGvHD是影响移植后复发的独立危险因素。移植后应用去甲基化药物(HMA)辅以G-CSF动员的供者淋巴细胞输注(DLI)维持治疗可提高移植后复发患者的总生存率,2年OS率为62.5%。结论:allo-HSCT可大大提高AML患者的生存率,但移植后复发仍为影响生存的主要因素之一。应用HMA联合DLI维持治疗可能成为治疗移植后复发患者新的有效方法。 展开更多
关键词 急性髓系白血病 异基因造血干细胞移植 生存 复发 去甲基化药物
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地西他滨治疗移植后复发MDS/AML及高危AML患者的临床疗效分析 被引量:6
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作者 王清云 梁赜隐 +6 位作者 董玉君 尹玥 王倩 刘微 许蔚林 李渊 任汉云 《中国实验血液学杂志》 CAS CSCD 北大核心 2020年第1期248-254,共7页
目的:探讨异基因造血干细胞移植(allo-HSCT)后复发的骨髓增生异常综合征/急性髓系白血病(MDS/AML)患者应用含地西他滨的化疗方案缓解后继续维持治疗的效果及高危AML在allo-HSCT后进行预防性输注地西他滨的疗效。方法:对2016年11月至2018... 目的:探讨异基因造血干细胞移植(allo-HSCT)后复发的骨髓增生异常综合征/急性髓系白血病(MDS/AML)患者应用含地西他滨的化疗方案缓解后继续维持治疗的效果及高危AML在allo-HSCT后进行预防性输注地西他滨的疗效。方法:对2016年11月至2018年5月于本院行allo-HSCT术后的10例MDS/AML患者进行回顾性分析,包括AML 4例,MDS 2例,MDS转化的AML(t-AML)4例。10例患者中移植后复发8例,高危AML移植后应用地西他滨预防2例。复发组患者应用地西他滨+化疗达完全缓解(CR)后,继续应用地西他滨维持治疗;预防组患者在移植后30至45 d、无移植物抗宿主病(GVHD)前提下,给予预防性地西他滨输注。8例患者辅以G-CSF动员的供者淋巴细胞输注(DLI)。地西他滨维持治疗及预防性输注的剂量为5 mg/m2×(7-10)d,每4-6周为1个疗程,共3-7个疗程。结果:随访至2018年11月30日,10例患者中7例无病存活,平均生存期为15.5±1.9个月,1年总生存(OS)率为64.0%。10例患者中发生急性GVHD及慢性GVHD者分别为6例和4例。结论:应用地西他滨+DLI治疗allo-HSCT后复发MDS/AML及高危AML患者在allo-HSCT后预防应用地西他滨,可延长无病生存期,降低复发率,为患者获得长期生存提供可能。 展开更多
关键词 地西他滨 AML MDS 异基因造血干细胞移植 复发 预防
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达沙替尼联合化疗序贯异基因造血干细胞移植治疗Ph染色体阳性急性淋巴细胞白血病的临床分析 被引量:6
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作者 李渊 王冰洁 +7 位作者 刘微 梁赜隐 尹玥 董玉君 王倩 孙玉华 许蔚林 任汉云 《中国实验血液学杂志》 CAS CSCD 北大核心 2020年第1期18-23,共6页
目的:观察第二代酪氨酸激酶抑制剂(TKI)达沙替尼联合化疗并序贯异基因造血干细胞移植(allo-HSCT)治疗Ph染色体阳性急性淋巴细胞白血病(Ph^+ALL)患者的临床疗效、治疗相关副反应及长期生存情况。方法:选取2012年1月至2018年9月于北京大... 目的:观察第二代酪氨酸激酶抑制剂(TKI)达沙替尼联合化疗并序贯异基因造血干细胞移植(allo-HSCT)治疗Ph染色体阳性急性淋巴细胞白血病(Ph^+ALL)患者的临床疗效、治疗相关副反应及长期生存情况。方法:选取2012年1月至2018年9月于北京大学第一医院确诊为Ph^+ALL,并应用达沙替尼联合化疗及序贯allo-HSCT治疗的19例患者,收集病历资料并进行相关数据统计分析。结果:19例患者中,男性10例,女性9例,中位年龄29(3-48)岁。P190阳性14例,P210阳性5例,3例为复杂染色体核型,3例合并脑膜白血病。化疗方案采用VDCLP方案诱导化疗,缓解后应用HD-MTX及MAE等方案巩固强化治疗。11例(57.9%)诱导化疗开始时即加用达沙替尼,3例(15.8%)因粒缺或感染于诱导缓解后加用,5例(26.3%)由伊马替尼更换为达沙替尼。3例出现副反应,分别表现为皮疹、浮肿、恶心。诱导治疗4周100%患者达形态学缓解;7例(63.6%)达主要分子学缓解(MMR),移植前17例(89.5%)达MMR,15例(78.9%)达完全分子学缓解(CMR)。所有患者均接受亲缘骨髓及外周血造血干细胞移植,中位白细胞及血小板植活时间分别为移植后12、14 d,aGVHD发生率为42.1%,cGVHD发生率为57.9%。移植后,13例患者恢复使用达沙替尼,7例因严重头痛、剧烈呕吐或浆膜腔积液停药,6例持续使用至移植后1年。中位随访42个月(10-72月),3年及5年总生存(OS)率均为94.4%,3年及5年非复发生存(RFS)率分别为81.9%及71.6%。结论:一线选用第二代TKI达沙替尼联合化疗并序贯allo-HSCT治疗Ph^+ALL有效性高,患者临床耐受性良好,患者长期生存可能优于第一代TKI治疗。 展开更多
关键词 费城染色体 急性淋巴细胞白血病 达沙替尼 酪氨酸激酶抑制剂 异基因造血干细胞移植
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异基因造血干细胞移植术治疗骨髓增生异常综合征患者临床疗效的分析 被引量:5
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作者 王清云 董玉君 +6 位作者 王倩 刘微 孙玉华 尹玥 梁赜隐 许蔚林 李渊 《中国实验血液学杂志》 CAS CSCD 北大核心 2021年第1期172-180,共9页
目的:分析异基因造血干细胞移植术(allo-HSCT)治疗骨髓增生异常综合征(MDS)患者的临床疗效,并探讨移植后复发的治疗新策略。方法:选取并回顾性分析2013年4月至2019年11月于北京大学第一医院行allo-HSCT的MDS患者共72例,总结移植疗效,并... 目的:分析异基因造血干细胞移植术(allo-HSCT)治疗骨髓增生异常综合征(MDS)患者的临床疗效,并探讨移植后复发的治疗新策略。方法:选取并回顾性分析2013年4月至2019年11月于北京大学第一医院行allo-HSCT的MDS患者共72例,总结移植疗效,并对影响患者生存及复发的危险因素进行探讨。结果:72例患者中,中位随访时间37(12~111)个月,57例(79.2%)患者存活,15例(20.8%)死亡。5年总生存(OS)率、无病生存(DFS)率分别为76.6%和62.3%。IPSS-R预后危险分层、TP53突变、慢性移植物抗宿主病(cGVHD)为影响患者移植后OS的危险因素,IPSS-R预后危险分层、TP53突变、Ⅲ-Ⅳ度急性移植物抗宿主病(aGVHD)为影响患者移植后DFS的危险因素。移植后,19例(26.4%)患者发生aGVHD,5例(6.9%)患者发生Ⅲ-Ⅳ度aGVHD,25例(34.7%)患者发生cGVHD,4例(5.6%)发生广泛型cGVHD。17例(23.3%)患者在移植后出现复发,5年的累积复发率为27.5%,IPSS-R预后危险分层、TP53突变、cGVHD为影响患者复发的危险因素。复发后中位生存时间为9个月。复发后有7例患者获得无病生存,10例死亡,接受甲基化药物(HMA)联合G-CSF动员的供者淋巴细胞输注(DLI)维持治疗患者的3年OS率显著高于未接受维持治疗的患者(80.0%vs 10.0%,P=0.002)。结论:allo-HSCT是治疗中高危MDS患者的有效方法,但移植后复发仍为影响患者生存的主要因素。多次HMA联合DLI的维持治疗可能提高移植后复发患者的长期生存。 展开更多
关键词 骨髓增生异常综合征 异基因造血干细胞移植 生存 复发 去甲基化药物
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真实世界骨淋巴瘤的病理特征、治疗选择与患者预后评估 被引量:4
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作者 欧晋平 高爽 +17 位作者 王莉红 张建华 农琳 刘微 王文生 孙玉华 许蔚林 尹玥 梁赜隐 王倩 李渊 董玉君 王清云 王茫桔 王冰洁 邱志祥 岑溪南 任汉云 《中国实验血液学杂志》 CAS CSCD 北大核心 2019年第3期796-801,共6页
目的:探讨骨淋巴瘤的临床特点、病理特征、治疗方法和患者预后。方法:回顾性分析北京大学第一医院2004年1月至2018年4月收治的34例骨淋巴瘤患者的临床特征、病理特点、治疗及预后。结果:34例骨淋巴瘤患者的中位年龄为56岁,男、女性别比... 目的:探讨骨淋巴瘤的临床特点、病理特征、治疗方法和患者预后。方法:回顾性分析北京大学第一医院2004年1月至2018年4月收治的34例骨淋巴瘤患者的临床特征、病理特点、治疗及预后。结果:34例骨淋巴瘤患者的中位年龄为56岁,男、女性别比例为1. 43∶1。原发性骨髓瘤(PBL) 8例,继发性骨髓瘤(SBL) 26例,PBL与SBL之比为0. 31∶1。PBL患者常无明显的全身症状,多因骨痛或病理性骨折起病。病理类型以DLBCL最多,占55. 88%。目前骨淋巴瘤的治疗方法为化疗,或化疗辅以放疗或手术,有条件者行造血干细胞移植治疗。本研究中骨淋巴瘤患者平均生存期为3. 49年,中位生存期为3年,3年生存率为82. 14%。影响生存期的因素有PBL和SBL分类、病理类型、血LDH水平和治疗方法。结论:骨淋巴瘤起病隐匿,选择足量、充分的联合治疗手段可提高患者的生存率,原发性骨淋巴瘤少见且预后较好,继发性骨淋巴瘤预后差。 展开更多
关键词 淋巴瘤 骨淋巴瘤 临床特征 治疗
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非全日制硕士研究生培育模式探索与建议 被引量:12
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作者 张法碧 周娟 +2 位作者 徐卫林 李琦 高兰英 《教育教学论坛》 2018年第15期198-199,共2页
教育部办公厅2016印发了《关于统筹全日制和非全日制研究生管理工作的通知》,这为今后研究生教育可持续发展的基本走向奠定了基调。统筹管理充分彰显出了当今研究生教育体系高质量趋势。本文基于统筹管理发展的要求,梳理了现阶段非全日... 教育部办公厅2016印发了《关于统筹全日制和非全日制研究生管理工作的通知》,这为今后研究生教育可持续发展的基本走向奠定了基调。统筹管理充分彰显出了当今研究生教育体系高质量趋势。本文基于统筹管理发展的要求,梳理了现阶段非全日制研究生培养的主要问题,提出了适应新形式、新发展的对策,为非全日制研究生管理、课程设置、授课方式和培养方式等提供参考。 展开更多
关键词 非全日制 统筹管理 课程设置
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特发性多中心型Castleman病患者细胞因子谱特征的初步分析 被引量:2
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作者 马宁 刘绘绘 +12 位作者 刘微 尹玥 王莉红 梁赜隐 许蔚林 王倩 李渊 王茫桔 欧晋平 王文生 岑溪南 任汉云 董玉君 《中国实验血液学杂志》 CAS CSCD 北大核心 2019年第4期1305-1310,共6页
目的:研究我国特发性多中心型Castleman病(idiopathic multicentric castleman disease,iMCD)患者血浆中细胞因子谱的特征性改变。方法:收集22例确诊iMCD患者治疗前的血浆标本,并以17例初发多发性骨髓瘤(MM)、10例非霍奇金淋巴瘤(NHL)... 目的:研究我国特发性多中心型Castleman病(idiopathic multicentric castleman disease,iMCD)患者血浆中细胞因子谱的特征性改变。方法:收集22例确诊iMCD患者治疗前的血浆标本,并以17例初发多发性骨髓瘤(MM)、10例非霍奇金淋巴瘤(NHL)及15例健康供者血浆标本作为对照,应用细胞因子磁珠阵列(cytokine beads array,CBA)和ELISA2种方法,检测17种细胞因子的浓度。结果:ELISA法检测的6种细胞因子中,iMCD患者的IL-2,IL-6,IL-21和VEGF的血浆水平均明显高于正常对照(P<0.01),且IL-21水平在iMCD组最高;IL-1β和IL-4水平与正常对照无差异。CBA法检测13种细胞因子浓度结果显示,iMCD患者的IL-6、IL-33和IL-12-p70水平均明显高于正常对照(P<0.01),其余细胞因子与正常对照相比均无显著差异(P>0.05)。结论:除了已知的IL-6和VEGF可能参与了iMCD的发生发展外,IL-2、IL-21、IL-12-p70和IL-33的作用值得进一步探讨,相关研究可能发现iMCD治疗的新型靶点。 展开更多
关键词 特发性多中心型Castleman病 细胞因子 浆细胞病 酶联免疫吸附法 细胞因子磁珠阵列法
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纯棉面料高导湿潮交联树脂整理工艺优化 被引量:2
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作者 耿彩花 张建祥 +3 位作者 徐卫林 田明伟 傅培涛 刘政钦 《印染》 北大核心 2019年第1期22-25,共4页
选取高导湿潮交联树脂,采用轧烘堆工艺制备高导湿性、高保形性面料,并研究树脂用量、pH值、堆置条件对面料整理效果的影响。结果表明,高导湿潮交联树脂既能赋予纯棉面料高免烫性和抗折皱性,又能保持面料原有手感及吸湿性能。优化的工艺... 选取高导湿潮交联树脂,采用轧烘堆工艺制备高导湿性、高保形性面料,并研究树脂用量、pH值、堆置条件对面料整理效果的影响。结果表明,高导湿潮交联树脂既能赋予纯棉面料高免烫性和抗折皱性,又能保持面料原有手感及吸湿性能。优化的工艺条件为:树脂整理剂210 g/L,pH=1.15,37℃堆置22 h。 展开更多
关键词 树脂整理 高导湿 潮交联 棉织物
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Analysis on Link Between the Macroscopic and Microscopic Air–Water Properties in Self-Aerated Flows 被引量:3
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作者 WEI Wang-ru xu wei-lin +2 位作者 DENG Jun TIAN Zhong ZHANG Fa-xing 《China Ocean Engineering》 SCIE EI CSCD 2018年第5期614-623,共10页
Self-aeration in high-speed free surface flows occurs commonly and is of interest to ocean engineering, hydraulic engineering, and environmental engineering. For two-phase air–water flows, macroscopic air–water flow... Self-aeration in high-speed free surface flows occurs commonly and is of interest to ocean engineering, hydraulic engineering, and environmental engineering. For two-phase air–water flows, macroscopic air–water flow properties develop gradually, accompanied by the change of microscopic air–water structures. In this article, representational experimental studies on macroscopic and microscopic characteristics of self-aerated open-channel flows are summarized and compared. The isolated effect of the flow Reynolds number and air quantity on the differences in air count rate and chord size are analyzed and discussed. The results show that the characterized flow depth y, affected by the turbulence transfer, is a specific criterion to distinguish the interior air–water structure development. Two distinct linear trends of self-aeration are found, depending on the y/yvariation with a breaking point at Cmean =0.50. The air count rate and size scale in self-aerated flows are affected by the air quantity of self-aerated flows, even with identical flow Reynolds numbers. Thus, a specific parameter is proposed to assess the air–water structures and a series of self-similarity relationships in self-aeration properties are obtained. The link between macroscopic and microscopic air–water properties results in significant scale effect on air–water structures in self-aerated flows. 展开更多
关键词 SELF-AERATION two-phase flows air concentration air bubble open channel
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Mechanical Properties of Small-diameter Superfine Silk Powder/Polyurethane Vascular Graft Reinforced by Tubular Knitted Fabric 被引量:3
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作者 ZHU Guo-cheng YANG Hong-jun +3 位作者 OUYANG Chen-xi xu wei-lin ZHANG Zhen YAN Yun 《Chinese Journal of Biomedical Engineering(English Edition)》 2010年第2期77-84,92,共9页
In this paper,a kind of composite microtube,which is made from superfine silk powder and polyurethane,reinforced by polyster and spandex tubular fabrics,was examined.The cross-section of composite microtubes were micr... In this paper,a kind of composite microtube,which is made from superfine silk powder and polyurethane,reinforced by polyster and spandex tubular fabrics,was examined.The cross-section of composite microtubes were microporous,and micropores were uniform distributed,the inner surface was relatively smooth.The results showed that the wall thickness of composite microtubes increased,which led to the strength,the breaking work and the initial modulus incresead;that the spandex content increased brought about the initial modulus and the breaking work decreased,but the breaking extension and the breaking load were firstly increased and then decreased;and all the mechanical properties decreased as the SFSP content increased. 展开更多
关键词 superfine silk powder(SFSP) polyurethane(PU) tubular fabric vascular graft mechanical property
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基于层次分析法的青海省矿泉水开发利用潜力评价
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作者 韦华鹏 许伟林 +3 位作者 罗银飞 张子琛 罗奇斌 康卫东 《地下水》 2022年第4期1-4,9,共5页
为给青海省矿泉水的评价规划与开发利用提供科学依据,根据青海省矿泉水的资源条件、自然条件和社会经济条件,构建了青海省矿泉水资源开发利用评价指标体系,确定了评价等级标准;基于层次分析法获得各评价指标的权重值,利用加权综合模型... 为给青海省矿泉水的评价规划与开发利用提供科学依据,根据青海省矿泉水的资源条件、自然条件和社会经济条件,构建了青海省矿泉水资源开发利用评价指标体系,确定了评价等级标准;基于层次分析法获得各评价指标的权重值,利用加权综合模型评价青海省41处矿泉水点的开发利用潜力;结合定性分析,将青海省矿泉水开发利用潜力分为了4个等级。评价结果表明:4个矿泉水点处于高潜力水平,19个矿泉水点处于较高潜力水平,评价结果具有科学性和合理性,将为青海省矿泉水的进一步的开发利用规划提供理论支撑。 展开更多
关键词 矿泉水 层次分析法 开发利用潜力评价
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Phenomenon of the sediment deposition in a hydraulic jump region of open channels
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作者 xu wei-lin WANG Guo-guang +1 位作者 FU Shi-hao WEI Wang-ru 《Journal of Mountain Science》 SCIE CSCD 2022年第7期1874-1885,共12页
The hydraulic jump is a typical sudden change for mountain river areas.The effects of local hydraulic jumps on the particle transport capacity decrease and local flow resistance increase cannot be ignored as the sedim... The hydraulic jump is a typical sudden change for mountain river areas.The effects of local hydraulic jumps on the particle transport capacity decrease and local flow resistance increase cannot be ignored as the sediment deposition disaster can amplify the flash flood disaster.The present research investigates the influences of a hydraulic jump on the individual particle movement and sediment deposition in a laboratory flume.The overall processes of a single particle movement are captured by a high-speed camera.The distribution of sediment deposition along the hydraulic jump is obtained statistically.The results show that both the particle size and the ratio of the upstream and downstream Froude numbers affect the particle motion process.A single particle coming from upstream gradually decelerates and finally stops at the hydraulic jump section because of hydraulic jump resistance.The particle acceleration first increases and then decreases during the time-domain process,and the attenuation trends are fast with the increase of ratio of upstream and downstream of Froude numbers.The increase of the maximum acceleration with sediment flows follows a linear trend approximately,which indicates that the kinetic features of the single sand particle are determined by the coupling effects of the hydraulic jump resistance and the sand dynamic properties.With the increase of sediment rate and sand particle size,the resistance effect of hydraulic jump on sediment deposition rate along the flow direction gets strong and the sediment deposition area is mainly located upstream of the hydraulic jump region.The present study shows that the possible sediment supply upstream must be obtained for identifying the disaster risk combined with the local hydraulic jump conditions.Further researches about the detailed critical condition deduced from the relationship between the water flow and sediment deposition are required to confirm and extrapolate present results to other applications. 展开更多
关键词 RATIO of UPSTREAM and DOWNSTREAM Froude
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程度补语“很”的历时发展及跨语言考察
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作者 徐玮琳 《枣庄学院学报》 2022年第1期41-49,共9页
程度副词“很”的补语用法始于明代,清代以后使用频率逐渐增加。程度补语“很”的产生一方面是语义虚化的结果,另一方面受到语用和认知的影响,体现了焦点居后原则和情感域到程度域的转化。现代汉语方言中,形式上,组合式程度补语“得很... 程度副词“很”的补语用法始于明代,清代以后使用频率逐渐增加。程度补语“很”的产生一方面是语义虚化的结果,另一方面受到语用和认知的影响,体现了焦点居后原则和情感域到程度域的转化。现代汉语方言中,形式上,组合式程度补语“得很”比粘合式程度补语“很”更具优势;意义上,有些方言中粘合式程度补语比组合式程度补语所表达的程度更高,相当于“太”“厉害”。跨语言考察中,粘合式程度补语比组合式程度补语更具优势,独龙语、哈尼语、彝语、藏语有补语居于述语之前的用法,说明补语位置的选择和基本语序有关,SVO结构的语言倾向于选择补语居后的表达,SOV的语言可以选择状语居前的表达。 展开更多
关键词 “很” 历时发展 共时分布 语用目的 认知阐释 跨语言
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EXPERIMENTAL INVESTIGATION OF THE FAILURE OF CASCADE LANDSLIDE DAMS 被引量:18
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作者 NIU Zhi-pan xu wei-lin +2 位作者 LI Nai-wen xuE Yang CHEN Hua-yong 《Journal of Hydrodynamics》 SCIE EI CSCD 2012年第3期430-441,共12页
This paper presents results of model tests for the landslide dam failure of a single dam and cascade dams in a sloping channel. The dams were designed to be regular trapezoid with fine sand. A new measuring method nam... This paper presents results of model tests for the landslide dam failure of a single dam and cascade dams in a sloping channel. The dams were designed to be regular trapezoid with fine sand. A new measuring method named the labeled line locating method was used to digitalize the captured instantaneous pictures. Under two different inflow discharges, the morphological evolution and the flow patterns during one dam failure and the failure of cascade dams were investigated. The results indicate that when the inflow discharge is large, the deformation pattern of the downstream dam is similar to that of the upstream dam, and both dams are characterized with the overtopping scour throughout the dam failure process. When the inflow discharge is small, the upstream dam is scoured mainly through a sluice slot formed by the longitudinal incision, and the downstream dam is characterized with the overtopping scour. The data set presented in this paper can be used for the validation of numerical models and provide a reference for the flood risk management of cascade landslide dams. 展开更多
关键词 labeled lines locating method inflow discharge cascade landslide dam failure OVERTOPPING sloping flume
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INTERACTION OF A CAVITATION BUBBLE AND AN AIR BUBBLE WITH A RIGID BOUNDARY 被引量:20
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作者 xu wei-lin BAI Li-xin ZHANG Fa-xing 《Journal of Hydrodynamics》 SCIE EI CSCD 2010年第4期503-512,共10页
The motion of a spark-induced cavitation bubble and an air bubble near a rigid boundary is experimentally studied by using high-speed photography.Several dimensionless parameters are used to describe the geometrical c... The motion of a spark-induced cavitation bubble and an air bubble near a rigid boundary is experimentally studied by using high-speed photography.Several dimensionless parameters are used to describe the geometrical configuration of the bubble-bubble-boundary interaction.The bubble-bubble interaction can be considered in two different conditions.The cavitation bubble will collapse towards the air bubble if the air bubble is relatively small,and away from the air bubble if the air bubble is relatively large.The two zones are identified in the bubble-boundary interaction,and they are the danger zone and the safety zone.The relative position,the bubble-boundary distance and the bubble-bubble distance play important roles in the bubble-bubble-boundary interaction,which can be considered in several conditions according to the responses of the bubbles.Air jets are found to penetrate into the cavitation bubbles.The cavitation bubble and the air bubble(air jet) move in their own way without mixing.The motion of a cavitation bubble may be influenced by an air bubble and/or a rigid boundary.The influence of the air bubble and the influence of the boundary may be combined,like some thing of a vector. 展开更多
关键词 cavitation bubble air bubble rigid boundary COLLAPSE
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EXPERIMENTAL STUDY OF DAM-BREAK FLOW IN CASCADE RESERVOIRS WITH STEEP BOTTOM SLOPE 被引量:12
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作者 xuE Yang xu wei-lin +3 位作者 LUO Shu-jing CHEN Hua-yong LI Nai-wen xu Ling-jun 《Journal of Hydrodynamics》 SCIE EI CSCD 2011年第4期491-497,共7页
Dam break can cause a significant disaster in the downstream, especially, in a valley with cascade reservoirs, which would aggravate the disaster extent. The experimental studies of the dam-break flow of cascade reser... Dam break can cause a significant disaster in the downstream, especially, in a valley with cascade reservoirs, which would aggravate the disaster extent. The experimental studies of the dam-break flow of cascade reservoirs are few and far between at the present, Most of related studies concern the failure of a single dam.. This article presents an experimental study of the characteristics of an instantly filled dam-break flow of cascade reservoirs in a rectangular glass flume with a steep bottom slope. A new method was used to simulate the sudden collapse of the dam. A series of sensors for automatic water-levels were deployed to record the rapid water depth fluctuation. The experimental results show that, the ratio of the initial water depth of the downstream reservoir to that of the upstream reservoir would greatly affect the flood peak water depth in the downstream reservoir area and in the stream channel behind the downstream dam, while the influence of the dam spacing is insignificant. In addition, the comparison between the single reservoir and the cascade reservoirs shows some difference in the dam-break flow pattern and the stage hydrograph at the corresponding gauging points. 展开更多
关键词 dam-break flow cascade reservoirs instantly full dam break steep bottom slope
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THE COUNTER-JET FORMATION IN AN AIR BUBBLE INDUCED BY THE IMPACT OF SHOCK WAVES 被引量:2
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作者 BAI Li-xin xu wei-lin +1 位作者 LI Chao GAO Yan-dong 《Journal of Hydrodynamics》 SCIE EI CSCD 2011年第5期562-569,共8页
The interaction of an air bubble (isolated in water or attached to a boundary) with shock waves induced by electric sparks is investigated by high-speed photography. The interaction is closely related to the counter... The interaction of an air bubble (isolated in water or attached to a boundary) with shock waves induced by electric sparks is investigated by high-speed photography. The interaction is closely related to the counter-jet induced by the impact of shock waves. The formation of a counter-jet in an air bubble is related to the liquid jet formed in the same air bubble, but the mechanism is different with that of the counter-jet formation in a collapsing cavitation bubble. The formation of a counter-jet in an air bubble is related to discharge energy, air bubble size and radius of shock wave. With a given energy of the spark discharge, the formation of a counter-jet in an air bubble is related to δ / ε (the ratio of the dimensionless bubble-bubble distance to the dimensionless air bubble radius). The counter-jet will only be produced when δ / ε is in the range of 1.2-2.2. The counter-jet in an air bubble is of an important nuclei-generating mechanism. 展开更多
关键词 cavitation bubble shock wave counter-jet high-speed photography
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NUMERICAL SIMULATION OF FLOW FOLD OF A RIVER WITH COMPLICATED BOUNDARIES 被引量:2
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作者 xu wei-lin Liao Hua-sheng (State Key Hydraulics Lab. of High Speed Flows, Sichuan Union University, Chengdu 610065, P. R. China) 《Journal of Hydrodynamics》 SCIE EI CSCD 1996年第3期75-80,共6页
The flow field of a river with complicated boundaries is simulated by dividing the calculation domain into several subdomains and using the depth-averaged k-ε turbulence model. The complicated topographic conditions ... The flow field of a river with complicated boundaries is simulated by dividing the calculation domain into several subdomains and using the depth-averaged k-ε turbulence model. The complicated topographic conditions in this paper include bar, confluence, narrow, bay and bend, etc. The lands emerging from the water surface are treated as blocked-off regions. The calculation is achieved at both the low and the high water levels. The velocity profiles along cross-sections are measured at the high water level in physical model. The calculated and measured velocity profiles are in agreement. 展开更多
关键词 numerical simulation natural river complicated boundary
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SCALE EFFECT OF I MPINGING PRESSURE CAUSED BY SUBMERGED JET 被引量:1
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作者 TIAN Zhong xu wei-lin +2 位作者 WANG Wei LIU Shan-jun DONG Jian-wei 《Journal of Hydrodynamics》 SCIE EI CSCD 2005年第4期478-482,共5页
The characteristics of the impinging pressure at the jet equipment where the maximum jet velocity can reach 50m/s were studied. By comparing the impinging pressure with the one measured at the low velocity conditions,... The characteristics of the impinging pressure at the jet equipment where the maximum jet velocity can reach 50m/s were studied. By comparing the impinging pressure with the one measured at the low velocity conditions, two conclusions of the scale effect are drawn: firstly, the velocity attenuation degree is smaller than that of low velocity jet, and secondly, the relative impinging width is narrower than that of low-velocity jet. The reasons of the scale effect of the impinging pressure were elucidated through numerical simulation. 展开更多
关键词 scale effect impinging pressure high-velocity jet numerical simulation
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EFFECT OF DISCHARGE RATIO ON FLOW CHARACTERISTICS IN 90°EQUAL-WIDTH OPEN-CHANNEL JUNCTION 被引量:1
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作者 ZHANG Ting xu wei-lin WU Chao 《Journal of Hydrodynamics》 SCIE EI CSCD 2009年第4期541-549,共9页
For the 90° equal-width open-channel junction flow, the Reynolds averaged Navier-Stokes equations are solved while using the 3-D κ- ω model. The mean flow pattern and the secondary current are obtained. The mod... For the 90° equal-width open-channel junction flow, the Reynolds averaged Navier-Stokes equations are solved while using the 3-D κ- ω model. The mean flow pattern and the secondary current are obtained. The model is validated by experimental data, and then applied to investigate the effect of the discharge ratio on the shape of separation zone shape, the cross-sectional mean flow angle and the contraction coefficient. The results are fairly close to those of the prior studies. The numerical modeling is both less time-consuming and less expensive to obtain the various flow parameters needed for engineering design. 展开更多
关键词 κ- ω turbulent model open-channel junction separation zone secondary current
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