Traditionally, Chinese indigenous cattle is geographically widespread. The present study analyzed based on genome-wide variants to evaluate the genetic background among 157 individuals from four representative indigen...Traditionally, Chinese indigenous cattle is geographically widespread. The present study analyzed based on genome-wide variants to evaluate the genetic background among 157 individuals from four representative indigenous cattle breeds of Hubei Province of China： Yiling yellow cattle （YL）, Bashan cattle （BS）, Wuling cattle （WL）, Zaobei cattle （ZB）, and 21 indi- viduals of Qinchuan cattle （QC） from the nearby Shanxi Province of China. Linkage disequilibrium （LD） analysis showed the LD of YL was the lowest （~=0.32） when the distance between markers was approximately 2 kb. Principle component analysis （PCA）, and neighbor-joining （NJ）-tree revealed a separation of Yiling yellow cattle from other geographic nearby local cattle breeds. In PCA plot, the YL and QC groups were segregated as expected; moreover, YL individuals clustered together more obviously. In the N J-tree, the YL group formed an independent branch and BS, WL, ZB groups were mixed. We then used the FST statistic approach to reveal long-term selection sweep of YL and other 4 cattle breeds. According to the selective sweep, we identified the unique pathways of YL, associated with production traits. Based on the results, it can be proposed that YL has its unique genetic characteristics of excellence resource, and it is an indispensable cattle breed in China.展开更多
目的比较丙泊酚闭环靶控输注与开环手动调节输注用于结直肠癌术中麻醉的疗效差异。方法将2017年2月—2019年2月于台州市中心医院收治的110例结直肠癌手术患者按随机数字表法分为研究组(55例)和对照组(55例)。研究组予以BIS指导下丙泊酚...目的比较丙泊酚闭环靶控输注与开环手动调节输注用于结直肠癌术中麻醉的疗效差异。方法将2017年2月—2019年2月于台州市中心医院收治的110例结直肠癌手术患者按随机数字表法分为研究组(55例)和对照组(55例)。研究组予以BIS指导下丙泊酚闭环靶控输注麻醉,对照组予以丙泊酚开环输注麻醉。监测T1(麻醉诱导前)、T2(插管时)、T3(切皮时)、T4(术毕)和T5(拔管时)HR、MAP和SPO2等血流动力学参数,记录手术时间、麻醉时间、丙泊酚用量、自主呼吸恢复时间、苏醒时间和拔管时间;观察不良反应;评价认知功能恢复情况。结果研究组T2~T4时刻MAP及T2时刻HR均高于对照组(均P<0.001),而研究组T3和T4时刻HR均低于对照组(均P<0.001)。研究组丙泊酚用量[(647.51±24.62)mg]低于对照组[(783.18±31.76)mg],自主呼吸恢复时间、苏醒时间和拔管时间均短于对照组(均P<0.001)。研究组术后1 d MMSE评分(26.69±1.32)高于对照组(24.95±1.46,t=3.802,P<0.001)。研究组不良反应发生率(9.09%)低于对照组(25.45%,χ2=5.153,P=0.023)。结论BIS指导下丙泊酚闭环靶控输注有利于维持结直肠癌患者术中血流动力学稳定,减少麻醉药物用量,缩短麻醉复苏时间,减轻不良反应,促进认知功能恢复。展开更多
Actinide-containing cluster compounds are highly important in radio-and nuclear chemistry.Until three decades ago,little attention had been paid to these heavy-element clusters because of difficulties in their synthes...Actinide-containing cluster compounds are highly important in radio-and nuclear chemistry.Until three decades ago,little attention had been paid to these heavy-element clusters because of difficulties in their syntheses and characterization as well as handling of these radioactive and chemotoxic elements.In this overview article we have selectively summarized the recent progresses in experimental and theoretical studies on actinide clusters,including actinide(An=Th,Pa,U,Np and Pu)oxide clusters as well as uranyl(UO22+)peroxide clusters and so on.It shows that An(Ⅳ)(An=Th,U,Np and Pu)is able to form highly symmetric AnⅣ6O8 core clusters and further merge into larger clusters up to An38O56 clusters(An=U,Np and Pu)with the same topology.Meanwhile,An with higher oxidation states such as U(Ⅵ)in uranyl is capable to form fullerene-like peroxide cage clusters of U20,U60 with the same topology as C20 and C60.Relativistic quantum chemistry investigations on the geometric structures,electronic structures and chemical bonding patterns have also been briefly summarized herein to provide an understanding on the structural chemistry of these peculiar clusters.The advances in electronic structure studies of actinide clusters help to develop robust theoretical and computational techniques for the future development of actinide cluster chemistry.Further experimental and computational studies of actinide clusters are needed and helpful to accelerate the development of radio-and nuclear chemistry.展开更多
基金funded in part by the National Natural Science Foundation of China (31402039,31472079,31372294)the Beijing Natural Science Foundation (6154032)+2 种基金the Species and Breed Resources Conservation of the Ministry of Agriculture of China (2017-2019)the Cattle Breeding Innovative Research Team of Chinese Academy of Agricultural Sciences (cxgc-ias-03)the National Beef Cattle Industrial Technology System (CARS-37)
文摘Traditionally, Chinese indigenous cattle is geographically widespread. The present study analyzed based on genome-wide variants to evaluate the genetic background among 157 individuals from four representative indigenous cattle breeds of Hubei Province of China： Yiling yellow cattle （YL）, Bashan cattle （BS）, Wuling cattle （WL）, Zaobei cattle （ZB）, and 21 indi- viduals of Qinchuan cattle （QC） from the nearby Shanxi Province of China. Linkage disequilibrium （LD） analysis showed the LD of YL was the lowest （~=0.32） when the distance between markers was approximately 2 kb. Principle component analysis （PCA）, and neighbor-joining （NJ）-tree revealed a separation of Yiling yellow cattle from other geographic nearby local cattle breeds. In PCA plot, the YL and QC groups were segregated as expected; moreover, YL individuals clustered together more obviously. In the N J-tree, the YL group formed an independent branch and BS, WL, ZB groups were mixed. We then used the FST statistic approach to reveal long-term selection sweep of YL and other 4 cattle breeds. According to the selective sweep, we identified the unique pathways of YL, associated with production traits. Based on the results, it can be proposed that YL has its unique genetic characteristics of excellence resource, and it is an indispensable cattle breed in China.
文摘目的比较丙泊酚闭环靶控输注与开环手动调节输注用于结直肠癌术中麻醉的疗效差异。方法将2017年2月—2019年2月于台州市中心医院收治的110例结直肠癌手术患者按随机数字表法分为研究组(55例)和对照组(55例)。研究组予以BIS指导下丙泊酚闭环靶控输注麻醉,对照组予以丙泊酚开环输注麻醉。监测T1(麻醉诱导前)、T2(插管时)、T3(切皮时)、T4(术毕)和T5(拔管时)HR、MAP和SPO2等血流动力学参数,记录手术时间、麻醉时间、丙泊酚用量、自主呼吸恢复时间、苏醒时间和拔管时间;观察不良反应;评价认知功能恢复情况。结果研究组T2~T4时刻MAP及T2时刻HR均高于对照组(均P<0.001),而研究组T3和T4时刻HR均低于对照组(均P<0.001)。研究组丙泊酚用量[(647.51±24.62)mg]低于对照组[(783.18±31.76)mg],自主呼吸恢复时间、苏醒时间和拔管时间均短于对照组(均P<0.001)。研究组术后1 d MMSE评分(26.69±1.32)高于对照组(24.95±1.46,t=3.802,P<0.001)。研究组不良反应发生率(9.09%)低于对照组(25.45%,χ2=5.153,P=0.023)。结论BIS指导下丙泊酚闭环靶控输注有利于维持结直肠癌患者术中血流动力学稳定,减少麻醉药物用量,缩短麻醉复苏时间,减轻不良反应,促进认知功能恢复。
基金financially supported by the Science Challenge Project(TZ2016004)the National Natural Science Foundation of China(Grant 21906094,91645203,21433005 and 21590792)The support of Guangdong Provincial Key Laboratory of Catalysis(No.2020B121201002)。
文摘Actinide-containing cluster compounds are highly important in radio-and nuclear chemistry.Until three decades ago,little attention had been paid to these heavy-element clusters because of difficulties in their syntheses and characterization as well as handling of these radioactive and chemotoxic elements.In this overview article we have selectively summarized the recent progresses in experimental and theoretical studies on actinide clusters,including actinide(An=Th,Pa,U,Np and Pu)oxide clusters as well as uranyl(UO22+)peroxide clusters and so on.It shows that An(Ⅳ)(An=Th,U,Np and Pu)is able to form highly symmetric AnⅣ6O8 core clusters and further merge into larger clusters up to An38O56 clusters(An=U,Np and Pu)with the same topology.Meanwhile,An with higher oxidation states such as U(Ⅵ)in uranyl is capable to form fullerene-like peroxide cage clusters of U20,U60 with the same topology as C20 and C60.Relativistic quantum chemistry investigations on the geometric structures,electronic structures and chemical bonding patterns have also been briefly summarized herein to provide an understanding on the structural chemistry of these peculiar clusters.The advances in electronic structure studies of actinide clusters help to develop robust theoretical and computational techniques for the future development of actinide cluster chemistry.Further experimental and computational studies of actinide clusters are needed and helpful to accelerate the development of radio-and nuclear chemistry.
