目的:通过可视化分析1985年--2021年针灸治疗缺血性脑中风的机制研究,归纳该领域的发展现状以及探测前沿热点。方法:运用Web of Science数据库高级检索功能检索针灸治疗缺血性脑中风机制研究的相关文献,将符合的文献运用Citespace软件...目的:通过可视化分析1985年--2021年针灸治疗缺血性脑中风的机制研究,归纳该领域的发展现状以及探测前沿热点。方法:运用Web of Science数据库高级检索功能检索针灸治疗缺血性脑中风机制研究的相关文献,将符合的文献运用Citespace软件对针灸治疗缺血性脑中风机制研究的作者、机构合作网络、参与国家、课题基金资助情况、共被引文献网络以及关键词共现图谱进行可视化分析。结果:作者合作图谱中共有181位作者纳入,并且发文篇数均为2篇以上;机构合作图谱共有53家参与,发文量>7篇的共有12个机构;参与区域共有5个,主要为中国学者;资助课题总计261篇(62%),其中182篇为国家自然科学基金资助;共被引文献具有重要参考意义的共有10篇;关键词共现分析有131个关键词被纳入,关键词使用频次>10次的共有46个,timezone时序探测分析1985年--2021年各个时间段关键词热点。结论:可视化分析展示归纳了近年来该领域作者、机构合作、文献共被引网络以及关键词预测热点研究(“自噬,信号通路,磷酸化,线粒体损伤障碍,突触可塑性”),为研究者提供潜在的机构和研究合作者,提供后续选题参考依据以及热点研究发展动向。展开更多
OBJECTIVE:To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.METHODS:We searched for all relevant trials published through Oct 7,2022 fro...OBJECTIVE:To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.METHODS:We searched for all relevant trials published through Oct 7,2022 from seven databases.Methodological quality was assessed using the CAMARADES Risk of Bias Tool.A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.RESULTS:A total of 101 studies involving 2148 animals were included.For most studies,primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness[Standardized Mean Difference(SMD)=1.41,95%confidence interval(CI)(0.59,2.23),P=0.0008],numerical density of synapses[SMD=1.55,95%CI(0.48,2.63),P=0.005]compared with non-EA-treated.Similarly,EA could improve parts of biomarkers of synapses,neurogenesis,angiogenesis and neurotrophin activity than the control group(P<0.05).CONCLUSION:The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity.More rigorous and high quality studies should be conducted in the future.展开更多
文摘目的:通过可视化分析1985年--2021年针灸治疗缺血性脑中风的机制研究,归纳该领域的发展现状以及探测前沿热点。方法:运用Web of Science数据库高级检索功能检索针灸治疗缺血性脑中风机制研究的相关文献,将符合的文献运用Citespace软件对针灸治疗缺血性脑中风机制研究的作者、机构合作网络、参与国家、课题基金资助情况、共被引文献网络以及关键词共现图谱进行可视化分析。结果:作者合作图谱中共有181位作者纳入,并且发文篇数均为2篇以上;机构合作图谱共有53家参与,发文量>7篇的共有12个机构;参与区域共有5个,主要为中国学者;资助课题总计261篇(62%),其中182篇为国家自然科学基金资助;共被引文献具有重要参考意义的共有10篇;关键词共现分析有131个关键词被纳入,关键词使用频次>10次的共有46个,timezone时序探测分析1985年--2021年各个时间段关键词热点。结论:可视化分析展示归纳了近年来该领域作者、机构合作、文献共被引网络以及关键词预测热点研究(“自噬,信号通路,磷酸化,线粒体损伤障碍,突触可塑性”),为研究者提供潜在的机构和研究合作者,提供后续选题参考依据以及热点研究发展动向。
基金National Natural Science Foundation of China Project:Electroacupuncture Prevents Ferroptosis in Ischemic Stroke Through Regulating Ubiquitin Ligase NEDD4-like E3 and Inhibiting Ferritinophagy Pathway(No.82104978)Scientific Research of Shaanxi Provincial Department of Education of China Project:Mechanism of Acupuncture on Microglia Activation in Mice with Cerebral Ischemia-Reperfusion(No.23JK0410)。
文摘OBJECTIVE:To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.METHODS:We searched for all relevant trials published through Oct 7,2022 from seven databases.Methodological quality was assessed using the CAMARADES Risk of Bias Tool.A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.RESULTS:A total of 101 studies involving 2148 animals were included.For most studies,primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness[Standardized Mean Difference(SMD)=1.41,95%confidence interval(CI)(0.59,2.23),P=0.0008],numerical density of synapses[SMD=1.55,95%CI(0.48,2.63),P=0.005]compared with non-EA-treated.Similarly,EA could improve parts of biomarkers of synapses,neurogenesis,angiogenesis and neurotrophin activity than the control group(P<0.05).CONCLUSION:The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity.More rigorous and high quality studies should be conducted in the future.
