目的采用孟德尔随机化分析方法,探讨臀围与2型糖尿病的因果关联。方法将分别来自人体测量特征遗传研究(genetic investigation of anthropometric traits,GIANT)和糖尿病遗传学验证和苔萃分析(diabetes genetics replication and Meta-a...目的采用孟德尔随机化分析方法,探讨臀围与2型糖尿病的因果关联。方法将分别来自人体测量特征遗传研究(genetic investigation of anthropometric traits,GIANT)和糖尿病遗传学验证和苔萃分析(diabetes genetics replication and Meta-analysis,DIAGRAM)数据库的臀围和2型糖尿病遗传位点数据,据单核苷酸多态性(single nucleotide polymorphism,SNP)编号匹配合并,以与臀围密切相关的SN P为工具变量,运用逆方差加权法、MR-Egger回归模型和加权中位数法分析臀围对2型糖尿病的因果效应。结果不分性别队列、女性队列和男性队列中分别匹配到52、9和15个SNP。异质性检验结果提示SNP间同质。三个队列的OR值及其95%的置信区间分别为1.065(1.030~1.100)、1.103(1.057~1.150)和1.583(1.273~1.968),均有统计学意义(均有P<0.05)。敏感性分析结果显示三个队列逐一移除SNP,其因果效应不受影响,结果稳健。结论人体臀围与2型糖尿病之间均存在因果关联,臀围可能为2型糖尿病的危险因素。展开更多
Background Hemorrhagic fever with renal syndrome (HFRS) is endemic in Junan county, Shandong Province, China. We conducted geographic information system (GIS)-based spatial analysis with the objective of estimatin...Background Hemorrhagic fever with renal syndrome (HFRS) is endemic in Junan county, Shandong Province, China. We conducted geographic information system (GIS)-based spatial analysis with the objective of estimating the spatial distribution of rodent populations and their hantavirus infection patterns, to describe the spatial relationships of hantavirus strains in small ecological areas and to identify key areas in endemic areas of HFRS for future public health planning and resource allocation.展开更多
基金This study was supported by a grant from the National Natural Science Foundation of China (No. 30471489).
文摘Background Hemorrhagic fever with renal syndrome (HFRS) is endemic in Junan county, Shandong Province, China. We conducted geographic information system (GIS)-based spatial analysis with the objective of estimating the spatial distribution of rodent populations and their hantavirus infection patterns, to describe the spatial relationships of hantavirus strains in small ecological areas and to identify key areas in endemic areas of HFRS for future public health planning and resource allocation.