Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could ...Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could be killed. The increased metastasis induced by radiation is associated with the activation of STAT3?in lung adenocarcinoma cells. Based on the importance role of?STAT3?in cell proliferation and survival, we can construct an adenovirus vector of?PIAS3 overexpress driven by radiation-induced promoter to inhibit the activation of STAT3 specifically. In this way, when?STAT3 was activated by radiation, the expression of?PIAS3 will be increased at the same time;this lead to the inhibition of invasion and metastasis caused by?STAT3 in lung adenocarcinoma cells. These researches are expected to develop a novel target and method for radiotherapy and molecular therapy of lung adenocarcinoma.展开更多
文摘Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could be killed. The increased metastasis induced by radiation is associated with the activation of STAT3?in lung adenocarcinoma cells. Based on the importance role of?STAT3?in cell proliferation and survival, we can construct an adenovirus vector of?PIAS3 overexpress driven by radiation-induced promoter to inhibit the activation of STAT3 specifically. In this way, when?STAT3 was activated by radiation, the expression of?PIAS3 will be increased at the same time;this lead to the inhibition of invasion and metastasis caused by?STAT3 in lung adenocarcinoma cells. These researches are expected to develop a novel target and method for radiotherapy and molecular therapy of lung adenocarcinoma.
