目的:探究超重或肥胖2型糖尿病(T2DM)患者的舌象与年龄、体质量指数(BMI)、并发症、实验室指标之间的相关性。方法:应用DS01-G手持式舌象仪采集超重或肥胖T2DM患者的舌象,同时收集其他观测指标。结果:青年全舌质Lab-L值高于老年;青年齿...目的:探究超重或肥胖2型糖尿病(T2DM)患者的舌象与年龄、体质量指数(BMI)、并发症、实验室指标之间的相关性。方法:应用DS01-G手持式舌象仪采集超重或肥胖T2DM患者的舌象,同时收集其他观测指标。结果:青年全舌质Lab-L值高于老年;青年齿痕出现频率高于年轻老年和老年。全舌质Lab-L、全舌质Lab-b、全舌苔Lab-b与体质量指数(BMI)正相关;肥胖出现苔腻频率高于超重。伴有慢性并发症苔腻出现频率高于不伴有慢性并发症;伴有慢性并发症点刺出现频率低于不伴有慢性并发症;大血管并发症全舌质Lab-a值小于无并发症。舌色参数与空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)、尿酸有相关性。通过回归分析得到4个回归方程:FBG=64.045-0.409×全舌Lab-b,TC=1.251+0.034×全舌苔Lab-L,LDL-C=-16.986+0.139×全舌苔Lab-a,Apo B=13.111+0.028×全舌苔Lab-a。结论:超重或肥胖T2DM病患者的舌象特征与年龄、BMI、并发症、实验室指标有相关性,并对一些实验室指标有预测作用。展开更多
OBJECTIVES:To observe the efficacy of Shenlian formula(SL formula,参连方),which consist of Huanglian(Rhizoma Coptidis)and Renshen(Radix Ginseng),in the treatment of type 2 diabetes mellitus(T2DM)and explore the effect...OBJECTIVES:To observe the efficacy of Shenlian formula(SL formula,参连方),which consist of Huanglian(Rhizoma Coptidis)and Renshen(Radix Ginseng),in the treatment of type 2 diabetes mellitus(T2DM)and explore the effects on gut microbiota and serum inflammatory cytokines.METHODS:In a double-blind,randomized,placebocontrolled parallel-group clinical trial,31 adults with T2DM were randomly allocated to receive the SL formula or placebo for 12 weeks.Body mass index(BMI),blood lipid indices,glycemic biomarkers including glycated hemoglobin(HbA1C),fasting plasma glucose(FPG),postprandial blood glucose(PBG),fasting insulin levels(FIL),fasting C-peptide(C-P),homoeostasis model assessment for insulin resistance(HOMA-IR)and inflammatory cytokines were assessed at baseline and 12 weeks.The contents of gut microbiota were determined by pyrosequencing of the V3-V4 regions of 16S rRNA genes.RESULTS:Sixteen cases were allocated in the treatment group and 15 in the placebo group.Compared with the placebo,SL formula resulted in a higher significant reduction in PBG[(-1.318±0.772)vs(-0.008±1.404)mmol/L,P=0.003],BMI[(-0.611±0.524)vs(0.957±2.212)kg/m2,P=0.01],FIL[(-1.627±6.268)vs(3.976±6.85)μIU/mL,P=0.02],HOMA-IR[(-0.530±1.461)vs(1.511±2.288),P=0.006],and C-reactive protein(CRP)[(-1.307±0.684)vs(0.828±0.557)mg/L,P=0.04].In terms of gut microbiota,compared with the placebo,the SL formula resulted in a significant decrease in species richness and evenness.CONCLUSIONS:The SL formula showed the efficacy to improve postprandial blood glucose,insulin resistance,BMI and CRP levels.In addition,it could reduce the total number,richness and evenness of species,meanwhile increase the abundance of probiotics to modulate the structure of gut microbiota in patients with T2DM.However,further studies are required for exploring the deeper mechanism of TCM on gut microbiota.展开更多
文摘目的:探究超重或肥胖2型糖尿病(T2DM)患者的舌象与年龄、体质量指数(BMI)、并发症、实验室指标之间的相关性。方法:应用DS01-G手持式舌象仪采集超重或肥胖T2DM患者的舌象,同时收集其他观测指标。结果:青年全舌质Lab-L值高于老年;青年齿痕出现频率高于年轻老年和老年。全舌质Lab-L、全舌质Lab-b、全舌苔Lab-b与体质量指数(BMI)正相关;肥胖出现苔腻频率高于超重。伴有慢性并发症苔腻出现频率高于不伴有慢性并发症;伴有慢性并发症点刺出现频率低于不伴有慢性并发症;大血管并发症全舌质Lab-a值小于无并发症。舌色参数与空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)、尿酸有相关性。通过回归分析得到4个回归方程:FBG=64.045-0.409×全舌Lab-b,TC=1.251+0.034×全舌苔Lab-L,LDL-C=-16.986+0.139×全舌苔Lab-a,Apo B=13.111+0.028×全舌苔Lab-a。结论:超重或肥胖T2DM病患者的舌象特征与年龄、BMI、并发症、实验室指标有相关性,并对一些实验室指标有预测作用。
基金the National Key R&D Program of China:the Study on Syndrome Differentiation Standard of Yin Deficiency Syndrome in Type 2 Diabetes Mellitus(2018YFC1704402)the Project for Young Teachers of Beijing University of Chinese Medicine:Clinical Study on Intervention of Shenlian Formula based on Microbiota in Type 2 Diabetes Mellitus(No.2018-JYBZZ-JS062)。
文摘OBJECTIVES:To observe the efficacy of Shenlian formula(SL formula,参连方),which consist of Huanglian(Rhizoma Coptidis)and Renshen(Radix Ginseng),in the treatment of type 2 diabetes mellitus(T2DM)and explore the effects on gut microbiota and serum inflammatory cytokines.METHODS:In a double-blind,randomized,placebocontrolled parallel-group clinical trial,31 adults with T2DM were randomly allocated to receive the SL formula or placebo for 12 weeks.Body mass index(BMI),blood lipid indices,glycemic biomarkers including glycated hemoglobin(HbA1C),fasting plasma glucose(FPG),postprandial blood glucose(PBG),fasting insulin levels(FIL),fasting C-peptide(C-P),homoeostasis model assessment for insulin resistance(HOMA-IR)and inflammatory cytokines were assessed at baseline and 12 weeks.The contents of gut microbiota were determined by pyrosequencing of the V3-V4 regions of 16S rRNA genes.RESULTS:Sixteen cases were allocated in the treatment group and 15 in the placebo group.Compared with the placebo,SL formula resulted in a higher significant reduction in PBG[(-1.318±0.772)vs(-0.008±1.404)mmol/L,P=0.003],BMI[(-0.611±0.524)vs(0.957±2.212)kg/m2,P=0.01],FIL[(-1.627±6.268)vs(3.976±6.85)μIU/mL,P=0.02],HOMA-IR[(-0.530±1.461)vs(1.511±2.288),P=0.006],and C-reactive protein(CRP)[(-1.307±0.684)vs(0.828±0.557)mg/L,P=0.04].In terms of gut microbiota,compared with the placebo,the SL formula resulted in a significant decrease in species richness and evenness.CONCLUSIONS:The SL formula showed the efficacy to improve postprandial blood glucose,insulin resistance,BMI and CRP levels.In addition,it could reduce the total number,richness and evenness of species,meanwhile increase the abundance of probiotics to modulate the structure of gut microbiota in patients with T2DM.However,further studies are required for exploring the deeper mechanism of TCM on gut microbiota.
